STILL out of Breath?

Robillard,

doi:10.4021/jmc1202w

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…A Mycobacterium tuberculosis-specific ELISPOT (T-SPOT.TB) assay was performed, and the results were negative. The number of nucleated cells in the pleural effusion was 1,760×10 6 /L, and the percentages of mononuclear cells and multinucleate cells were 80% and 20%, respectively. Her adenosine deaminase level was within the normal range.…”

Section: Case Reportmentioning

confidence: 93%

A Rare Case of Diffuse Pulmonary Nodules in a Patient with Adult-onset Still's Disease

Yin

Xiao

et al. 2014

Intern. Med.

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Adult-onset Still's disease (AOSD) is a multisystemic inflammatory disorder, but pulmonary involvement is rare. We herein describe the case of a woman diagnosed with AOSD; treatment resolved her symptoms, but nine days later she was admitted with pyrexia and a productive cough. A chest X-ray revealed diffuse pulmonary nodules and patchy shadows. A high-resolution chest computed tomography scan confirmed diffuse infiltration in the pulmonary parenchyma, signs of alveolar nodules, distribution along the lobule center, several areas of tree-in-bud patterns, and bilateral pleural effusion. The patient was treated with high doses of corticosteroids, which rapidly reduced the size of her diffuse pulmonary nodules and dramatically improved her pleural effusion.

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Section: Case Reportmentioning

confidence: 93%

A Rare Case of Diffuse Pulmonary Nodules in a Patient with Adult-onset Still's Disease

Yin

Xiao

et al. 2014

Intern. Med.

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“…PAH is a very rare complication of AOSD, but its prevalence is probably underestimated because only symptomatic case reports have been documented (11). To our knowledge, 15 cases have been reported (110)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123). Age of onset ranged from 18 to 41 years old.…”

Section: Pulmonary Arterial Hypertensionmentioning

confidence: 99%

“…Anakinra was efficacious (in combination with vasodilators and corticosteroids, and either azathioprine or cyclosporine) in two case reports (one case also had RHL) (110,117). Failure was reported in one patient (121), and 3 patients (one died) showed worsening after its introduction (114,118,123). However, with the critical and unstable nature of this complication, drawing robust conclusions about the specific anakinra role in these unfavorable evolutions is difficult.…”

Section: Pulmonary Arterial Hypertensionmentioning

confidence: 99%

Complications of adult-onset Still’s disease and their management

Mitrovic

Fautrel

2018

Expert Review of Clinical Immunology

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Adult-onset Still's disease (AOSD) is a rare systemic auto-inflammatory disorder in which management and treatment have considerably progressed over the past decade. Despite wide use of interleukin (IL)-1 or IL-6 inhibitors, serious complications remain possible. Areas covered: A comprehensive literature search in MEDLINE via Pubmed was performed to review AOSD's severe and sometimes life-threatening complications: reactive hemophagocytic lymphohystiocytosis, coagulation disorders, fulminant hepatitis, cardiac or pulmonary complications and amyloid A amyloidosis. Expert commentary: Early recognition and prompt management is essential to significantly decrease morbi-mortality. The key question is to determine whether the complication is related to the disease itself or related to or favored by (e.g. infection) the ongoing treatment. For all severe AOSD-related complications, high-dose corticosteroids and supportive measures remain the first-line treatment. In case of inadequate response, combination with IL-1 or IL-6 blockers is justified. Cyclosporine A and etoposide remain of interest, especially in case of reactive hemophagocytic lymphohysitocytosis. Plasma exchange may be useful in case of thrombotic microangiopathy. In the near future, new biologic or non-biologic drugs targeting IL-18 or other cytokines or kinases could be of help.

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STILL out of Breath?

Cited by 2 publications

References 20 publications

A Rare Case of Diffuse Pulmonary Nodules in a Patient with Adult-onset Still's Disease

A Rare Case of Diffuse Pulmonary Nodules in a Patient with Adult-onset Still's Disease

Complications of adult-onset Still’s disease and their management

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