Here we identify a new form of optomechanical coupling in gas-filled hollow-core fibers. Stimulated forward Brillouin scattering is observed in air in the core of a photonic bandgap fiber. A single resonance is observed at 35 MHz, which corresponds to the first excited axial-radial acoustic mode in the air-filled core. The linewidth and coupling strengths are determined by the acoustic loss and electrostrictive coupling in air, respectively. A simple analytical model, refined by numerical simulations, is developed that accurately predicts the Brillouin coupling strength and frequency from the gas and fiber parameters. Since this form of Brillouin coupling depends strongly on both the acoustic and dispersive optical properties of the gas within the fiber, this new type of optomechanical interaction is highly tailorable. These results allow for forward Brillouin spectroscopy in dilute gases, could be useful for sensing and will present a power and noise limitation for certain applications.Hollow-core photonic bandgap fibers (HC-PBF) are unique for their ability to guide light in air through Bragg reflection from a periodic silica matrix that forms the waveguide cladding [1][2][3] (Fig. 1(a)). In comparison to conventional silica (step-index) fibers, Bragg guidance in HC-PBF drastically reduces the nonlinear interactions with silica and increases the power handling to permit new forms of high power laser delivery [4], pulse compression [5], and light sources [6]. Conversely, the introduction of atomic vapors within these hollow-core fibers produces sustained photon-atom interactions over unprecedented length scales, which enables new light sources for both classical [7] and quantum [8][9][10][11][12] applications. While electronic nonlinearities are widely studied in such fibers [1][2][3], comparatively little is known of their acousto-optic (or optomechanical) interactions, and the dynamics, and noise that they can produce. Only recently has coupling between MHz elastic waves within the silica matrix been quantified [13], and identified as a source of noise in quantum optics [13,14].In this paper, we show that photon-phonon coupling mediated by air (gasses) within the hollow core of the fiber constitutes a much larger and perhaps more tailorable form of optomechanical coupling. Through a combination of theory and experiment, we show that the hollow core of the fiber acts as a conduit for guided acoustic waves in air. Optical waves that are guided in this same region produce strong photo-acoustic coupling to these sound waves, yielding appreciable forwardBrillouin coupling at MHz frequencies. Using precision spectroscopy methods, we identify a single air-mediated Brillouin resonance at 35 MHz with 20 times stronger photo-acoustic coupling than is produced by elastic waves in the silica cladding alone. We show that the strength, frequency, and character of this Brillouin resonance is explained by the properties of the gas filling the core and the dimension of the hollow-core fiber. Since this form of Brillouin coupl...