Stimulating Effect of Unfractionated Heparin and a Low Molecular Weight Heparin Fragment on the DNA Synthesis Response of Human Thymocytes to Mercuric Chloride

Abstract

The effect of unfractionated heparin and a low molecular weight heparin fragment was tested on the DNA synthesis response of human thymocytes to mercuric chloride. In a concentration of 0.01–0.11 mg/ml, unfractionated heparin somewhat stimulated this response, while the heparin fragment at 11.1 mg/ml gave an evident stimulation of the response and a lower stimulation degree at 1.1 mg/ml.

Modulating Effects of Heparin Preparations on the DNA Synthesis Response of Human Peripheral Blood T Lymphocytes Activated by Mercuric Chloride and Nickel Sulfate

“…In a previous study [15] different concentrations of unfractionated heparin and a low molecular weight heparin fragment, isolated after partial depolymeriza tion of heparin with nitrous acid [1,7], were found to stimulate the DNA synthesis response of human thymocytes to mercuric chloride. In the present inves tigation, these heparin preparations were tested for a modulating effect on the response of peripheral blood T lymphocytes from nickel-allergic subjects after ad dition of nickel sulfate and mercuric chloride.…”