The COVID-19 pandemic, in the current conditions of globalization challenges, turned out to be one of the general reasons for a significant decrease in the level of economic security of economic systems, including at the level of companies. This updates the issue of guaranteeing the economic security of companies. The study aims to develop the conceptual and methodological foundations of the innovative and investment provision of the economic security of companies in the conditions of the challenges of COVID-19. The methodological principles of innovative and informative provision of the economic security of companies are based on a systemic approach, which allows considering the company as an open system in which economic security is one of the determining subsystems. It has been shown that the economic security of the company must ensure the achievement of the socio-economic goals set for the company in the conditions of the challenges of the COVID-19 pandemic, protecting the company from adverse factors and the negative impact of internal and external changes. It is emphasized that innovation is a determining factor of the economic development of the company, and therefore of economic security. The staggering of systematic steps to make management decisions is suggested to ensure the economic security of the company in the conditions of the challenges of COVID-19.