Stimulation of 5‐HT_1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats

Abstract

1 We studied whether the stimulation of 5-HTIA receptors by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a specific 5-HT,A receptor agonist, reduced electroencephalographic (EEG)

High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo

“…at the arrow. One-way AnOVA for repeated measures followed by Fisher's PLSD post hoc test; 8-OH-DPAt versus vehicle group, *p < 0.05, **p < 0.01 Salgado-Commissariat and Alkadhi 1997) and in vivo by different pharmacological models of tLE (Gariboldi et al 1996;Lopez-Meraz et al 2005. Moreover, the administration of WAY100635, a 5-Ht 1A antagonist, avoided the protective effect induced by the intrahippocampal infusion of serotonin on the development of pilocarpine-induced seizures (Clinckers et al 2004).…”

“…that has been shown to have an anticonvulsant effect (Salgado and Alkadhi 1995;Gariboldi et al 1996;Salgado-Commissariat and Alkadhi 1997;tokarski et al 2002;Lopez-Meraz et al 2005, on granular cell reactivity and short-and long-term plasticity.…”

Serotonin Hyperinnervation Abolishes Seizure Susceptibility inOtx2Conditional Mutant Mice

“…With respect to KA-induced seizures, the role of 5-HT 1A receptors has been clearly elucidated. Administration of 8-OH-DPAT [8-hydroxy-2-(di-n-propylamino)tetralin] (a specific 5-HT 1A agonist) reduces KA-evoked seizures in rats (Gariboldi et al, 1996), whereas increased lethality after KA seizures is observed in mice with targeted inactivation of the 5-HT 1A gene (Sarnyai et al, 2000). Mice lacking 5-HT 2C receptors also develop epilepsy (Tecott et al, 1995;Brennan et al, 1997).…”

PET imaging of 5-HT 1A receptor binding in patients with temporal lobe epilepsy

“…[2][3][4] Central 5-HT 1A receptors are found in high density in the brainstem raphe and in regions important for epilepsy, including the hippocampus and temporal neocortex. 14 In the in vitro hippocampal slice preparation, superfusion of either 5-HT or 8-hydroxy-2-(di-n-propylamine)tetralin (8-OH-DPAT), a selective 5-HT 1A receptor agonist, in the bath led to a dose-related reduction in the amplitude of population spike responses in CA1 evoked by electrical stimulation of Schaffer collaterals and in dentate gyrus evoked by stimulation of perforant path. 14 In the in vitro hippocampal slice preparation, superfusion of either 5-HT or 8-hydroxy-2-(di-n-propylamine)tetralin (8-OH-DPAT), a selective 5-HT 1A receptor agonist, in the bath led to a dose-related reduction in the amplitude of population spike responses in CA1 evoked by electrical stimulation of Schaffer collaterals and in dentate gyrus evoked by stimulation of perforant path.…”