Stimulation of aflatoxin B1 and T-2 toxin production by sorbic acid

Gareis, M.; Bauer, Julia; Montgelas, A von; Gedek, B.

doi:10.1128/aem.47.2.416-418.1984

Cited by 41 publications

(6 citation statements)

References 24 publications

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“…Other common acute manifestations of TBI include cognitive deficits in attention, learning and memory, and higher-order executive functions. However, these consequences can remain long after the initial injury. , TBI can additionally lead to the development of chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), and chronic traumatic encephalopathy (CTE). − As Masel and Dewitt (2010) describe, TBI is “a disease process, not an event”, referring to a common practice among insurance agencies to classify TBI as a singular injury. The long-term consequences of the injury need to be considered following initial treatment.…”

Section: Introductionmentioning

confidence: 99%

“…However, these consequences can remain long after the initial injury. 8,9 TBI can additionally lead to the development of chronic neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD), and chronic traumatic encephalopathy (CTE). 10−12 As Masel and Dewitt (2010) 13 describe, TBI is "a disease process, not an event", referring to a common practice among insurance agencies to classify TBI as a singular injury.…”

Section: ■ Introductionmentioning

confidence: 99%

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Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury

Glotfelty

Delgado

Tovar‐y‐Romo

et al. 2019

ACS Pharmacol. Transl. Sci.

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Traumatic brain injury (TBI) is becoming an increasing public health issue. With an annually estimated 1.7 million TBIs in the United States (U.S.) and nearly 70 million worldwide, the injury, isolated or compounded with others, is a major cause of short-and longterm disability and mortality. This, along with no specific treatment, has made exploration of TBI therapies a priority of the health system. Age and sex differences create a spectrum of vulnerability to TBI, with the highest prevalence among younger and older populations. Increased public interest in the long term effects and prevention of TBI have recently reached peaks, with media attention bringing heightened awareness to sport and war related head injuries. Along with short-term issues, TBI can increase the likelihood for development of long-term neurodegenerative disorders. A growing body of literature supports the use of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucagon (Gcg) receptor (R) agonists, along with unimolecular combinations of these therapies, for their potent neurotrophic/neuroprotective activities across a variety of cellular and animal models of chronic neurodegenerative diseases (Alzheimer's and Parkinson's diseases) and acute cerebrovascular disorders (stroke). Mild or moderate TBI shares many of the hallmarks of these conditions; recent work provides evidence that use of these compounds is an effective strategy for its treatment. Safety and efficacy of many incretinbased therapies (GLP-1 and GIP) have been demonstrated in humans for the treatment of type 2 diabetes mellitus (T2DM), making these compounds ideal for rapid evaluation in clinical trials of mild and moderate TBI.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury

Glotfelty

Delgado

Tovar‐y‐Romo

et al. 2019

ACS Pharmacol. Transl. Sci.

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“…The increased fumitremorgin production in media supplemented with potassium sorbate or sodium benzoate may be a result of utilization of these organic acids. Garleis et al (1984) also observed a stimulatory effect of small amounts of sorbic acid on aflatoxin production by Aspergillus flavus and T-2 production by Fusarium acuminatum. They concluded that this effect may be caused by a reduction in the activity of the tricarboxylic acid cycle, leading to an accumulation of acetyl coenzyme A, an essential intermediate in the biosynthesis of these mycotoxins.…”

Section: Discussionmentioning

confidence: 69%

Growth and fumitremorgin production by Neosartorya fischeri as affected by food preservatives and organic acids

Nielsen

Beuchat

Frisvad

1989

Journal of Applied Bacteriology

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The effects of potassium sorbate, sodium benzoate, sulphur dioxide and citric, malic and tartaric acids on growth and fumitremorgin production by a heat‐resistant mould, Neosartorya fischeri, cultured on Czapek yeast autolysate agar (CYA) were studied over a 32‐day incubation period. Colonies were examined, and extracts of agar and mycelia were analyzed for mycotoxin content using high performance liquid chromatography (HPLC). Growth of N. fischeri always resulted in production of the fumitremorgins verruculogen and fumitremorgin A and C. Growth on CYA (pH 3.5) was highly repressed by potassium sorbate and sodium benzoate; 75 mg/1 completely inhibited germination of ascospores. Sulphur dioxide was less inhibitory; growth occurred on CYA containing 100 but not 200 mg/1. Growth of N. fischeri was significantly reduced when the pH of CYA was reduced from 7.0 to 4.5 to 3.5 to 2.5. Citric, malic and tartaric acids promoted growth and fumitremorgin production when supplemented to CYA (pH 2.5). These observations indicate that growth and fumitremorgin production by N. fischeri are influenced by pH and type of acid present and can be controlled by small amounts of preservatives.

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“…Key molecules such as acetyl coenzyme A, ,-hydroxy-,B-methylglutaryl coenzyme A (HMGCoA), and mevalonate certainly play a part in the regulation mechanisms of trichothecene biosynthesis (2,14); but little is known on this subject. The use of subinhibitory concentrations of tricarboxylic acid cycle inhibitors such as sorbic acid generally increases trichothecene production by Fusarium strains (1,6). This increase is probably due to the accumulation of tricarboxylic acid cycle intermediates such as acetyl coenzyme A (6).…”

mentioning

confidence: 99%

Influence of metabolic and physical factors on production of diacetoxyscirpenol by Fusarium sambucinum Fuckel

Monnet

Vidal

Creach

1988

Appl Environ Microbiol

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Fusarium sambucinum Fuckel 8099-1 was grown on Czapek-Dox peptone-supplemented medium at 15°C for 14 days, and the cultures were investigated for diacetoxyscirpenol (DAS) production by liquid-liquid extraction and gas chromatography. The addition of 150 mg of sorbic acid, a tricarboxylic acid cycle inhibitor, per liter stimulated both fungal growth and DAS production. Among the 13-hydroxy-13-methylglutaryl coenzyme A precursors tested, isovaleric acid completely inhibited fungal growth and DAS production, ethyl isovalerate did not support a significant increase in DAS production, and L-leucine partially inhibited DAS production, showing that L-leucine and isovaleric acid catabolisms do not induce trichothecene biosynthesis. Solid particles (cork powder) were necessary for DAS production in stationary cultures but did not influence DAS production in shaken cultures. Shaking strongly stimulated DAS production and fungal growth.

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Stimulation of aflatoxin B1 and T-2 toxin production by sorbic acid

Cited by 41 publications

References 24 publications

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury

Growth and fumitremorgin production by Neosartorya fischeri as affected by food preservatives and organic acids

Influence of metabolic and physical factors on production of diacetoxyscirpenol by Fusarium sambucinum Fuckel

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