Stimulation of chenodeoxycholic acid excretion in hypercholesterolemic mice by dietary taurine.

Yamanaka, Yumiko; Tsuji, Kiichiro; Ichikawa, Tomio

doi:10.3177/jnsv.32.287

Cited by 49 publications

(25 citation statements)

References 23 publications

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“…Taurine play a role in conjugation reaction with bile acids in the liver. Consequently, bile acid synthesis is increased 53 by simultaneous rise in the messenger RNA (mRNA) expression and activity of cholesterol 7α-hydroxylase, a rate-limiting enzyme in hepatic bile acid synthesis. 54 The primary mechanisms responsible for the hypocholesterolemic action of taurine may be due to the increased conversion of cholesterol into bile acids through the stimulation of cholesterol 7α-hydroxylase enzyme activity.…”

Section: Discussionmentioning

confidence: 99%

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Ghosh¹,

Das²,

Paramanik³

et al. 2016

Toxicol Forensic Med Open J

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Extensive application of pesticides is usually accompanied with serious problems of pollution and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used in agriculture, home pest control and protection of foodstuff. This study designed to evaluate the dose dependent haematological, hepatic and gonadal toxicity of LCT at different dose levels in Wistar rat. Investigations were also done to find out the toxic effect of lambda cyhalothrin on lipid metabolism in female rat and its amelioration by taurine. Rats were exposed to different doses of lambda cyhalothrin over a period of 14 consecutive days. Exposure to LCT produced ataxia, agitation, rolling and also tremors which were considered as the signs of toxicity. Significant decrease in erythrocyte count, haemoglobin percentage, seminal fructose concentration, hepatic and testicular reduced glutathione (GSH) content was observed. Increase in leukocyte count, serum aspartic and alanine transaminase, hepatic and testicular malondialdehyde (MDA), testicular and ovarian cholesterol after LCT treatment were seen in male rats at the dose level of 10.83 mg/kg body wt. (1/7 th LD 50 ). Elevated ovarian cholesterol and MDA and reduced 3β hydroxy steroid dehydrogenase (HSD) and GSH level were also observed in lambda cyhalothrin exposed female rat at the dose level of 6.29 mg/kg body wt.(1/9 th LD 50 ). LCT caused increase in serum triglyceride, cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and bilirubin and decrease in serum high density lipoproteins (HDL) in female rat. Taurine pretreatment ameliorated LCT induced altered lipid metabolic biomarkers in female rat.

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Section: Discussionmentioning

confidence: 99%

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Ghosh¹,

Das²,

Paramanik³

et al. 2016

Toxicol Forensic Med Open J

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show abstract

“…Feces were collected for 2 d before sacrifice (d [12][13][14]. Neutral sterols and bile acids were extracted from dried and ground feces after saponification according to the procedure of Yamanaka et al 17) Fecal 3-hydroxy neutral sterols and 3-hydroxy bile acids were determined by enzymatic methods, 41) using commercial kits as described previously.…”

Section: )mentioning

confidence: 99%

“…Sulfur amino acids and such derivatives as L-methionine, 15,16) L-cystine, 16) and taurine [16][17][18] have changed the serum or plasma cholesterol concentration in the normal state. In the tumor-bearing state, L-methionine in combination with glycine 8) has reduced the serum (VLDL þ LDL)-cholesterol concentration.…”

mentioning

confidence: 99%

Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats

Kawasaki

Miura

Funabiki

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…We previously reported on the decrease in the incidence of gallstone formation and hepatic cholesterol mass (2,3) and the increase in fecal bile acid excretion (4) effected by dietary taurine in hypercholesterolemic mice. These results suggested that the protective effect of dietary taurine against cholesterol gallstone formation is related to the stimulation of bile acid synthesis (4).…”

mentioning

confidence: 68%

Effect of dietary taurine on cholesterol 7.ALPHA.-hydroxylase activity in the liver of mice fed a lithogenic diet.

Nakamura-Yamanaka

Tsuji

Ichikawa

1987

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Stimulation of chenodeoxycholic acid excretion in hypercholesterolemic mice by dietary taurine.

Cited by 49 publications

References 23 publications

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats

Effect of dietary taurine on cholesterol 7.ALPHA.-hydroxylase activity in the liver of mice fed a lithogenic diet.

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