Stimulation of healing within a rabbit calvarial defect by a PCL/PLGA scaffold blended with TCP using solid freeform fabrication technology

Shim, Jin‐Hyung; Moon, Taesup; Yun, Mi-Jung; Jeon, Young-Chan; Jeong, Chang-Mo; Cho, Dong‐Woo; Huh, Jung-Bo

doi:10.1007/s10856-012-4761-9

Cited by 93 publications

(75 citation statements)

References 44 publications

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“…In addition, powder materials, particularly those with thermal resistance, can be mixed with these thermoplastic polymers. Indeed, blends of PCL/PLGA [24], PCL/PLGA/powdered TCP [26] and PCL/PLGA/powdered antibiotics [18] have been shown to be potential candidates for engineering tissue scaffolds by 3D printing. …”

Section: Discussionmentioning

confidence: 99%

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Shim

Won²,

Park

et al. 2017

IJMS

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100

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This study was conducted to compare 3D-printed polycaprolactone (PCL) and polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) membranes with a conventional commercial collagen membrane in terms of their abilities to facilitate guided bone regeneration (GBR). Fabricated membranes were tested for dry and wet mechanical properties. Fibroblasts and preosteoblasts were seeded into the membranes and rates and patterns of proliferation were analyzed using a kit-8 assay and by scanning electron microscopy. Osteogenic differentiation was verified by alizarin red S and alkaline phosphatase (ALP) staining. An in vivo experiment was performed using an alveolar bone defect beagle model, in which defects in three dogs were covered with different membranes. CT and histological analyses at eight weeks after surgery revealed that 3D-printed PCL/β-TCP membranes were more effective than 3D-printed PCL, and substantially better than conventional collagen membranes in terms of biocompatibility and bone regeneration and, thus, at facilitating GBR.

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Section: Discussionmentioning

confidence: 99%

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Shim

Won²,

Park

et al. 2017

IJMS

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100

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show abstract

“…The optimal pore size for bone tissue engineering has been reported to be 200-400 µm [26]. Furthermore, the porous, fully interconnected structures produced integrate membranes with tissues by soft tissue penetration, which reduces the problems of membrane separation and exposure [32].…”

Section: Discussionmentioning

confidence: 99%

“…Of the 3D-printed scaffolds, blended PCL/PLGA/TCP scaffold showed the greatest compressive strengths and moduli and greatest human bone marrow stromal cells (hBMSC) adhesion and proliferation. Shim et al [26] also fabricated membrane-typed scaffolds with blended PCL/PLGA and PCL/PLGA/β-TCP, and evaluated their abilities to promote new bone formation in rabbit calvarial defects.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Shim

Won²,

Sung

et al. 2015

Polymers

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This study was conducted to evaluate the effects of a 3D-printed resorbable polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membrane on bone regeneration and osseointegration in areas surrounding implants and to compare results with those of a non-resorbable titanium mesh membrane. After preparation of PCL/PLGA/β-TCP membranes using extrusion-based 3D printing technology; mechanical tensile testing and in vitro cell proliferation testing were performed. Implant surgery and guided bone regeneration were performed randomly in three groups (a no membrane group, a titanium membrane group, and a PCL/PLGA/β-TCP membrane group (n = 8 per group)). Histological and histometric analyses were conducted to evaluate effects on bone regeneration and osseointegration. Using the results of mechanical testing; a PCL/PLGA/β-TCP ratio of 2:6:2 was selected. The new bone areas (%) in buccal defects around implants were highest in the PCL/PLGA/β-TCP group and significantly higher than in the control group (p < 0.05). Bone-to-implant contact ratios (%) were also significantly higher in the PCL/PLGA/β-TCP and titanium groups than in the control group (p < 0.05). When the guided bone regeneration procedure was performed using the PCL/PLGA/β-TCP membrane; new bone formation around the implant and osseointegration were not inferior to those of the non-resorbable pre-formed titanium mesh membrane.

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“…Such composite block bone grafts are used in various clinical procedures like socket preservation and typical GBR procedures [18,22,23]. However, although they have good handling properties and produce excellent bone augmentation results, they are more expensive than xenogenic bone graft substitutes, and, as a result, several studies have been conducted on the use of degradable polymer graft materials for bone regeneration [24,25,26]. …”

Section: Introductionmentioning

confidence: 99%

The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

et al. 2017

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In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo. Specimens of the following were prepared as 6 mm diameter, 2 mm thick discs; BPC mixed with CMC (the BCP/CMC group), BCP mixed with crosslinked CMC (the BCP/c-CMC group) and BCP mixed with HyA (the BCP/HyA group) and a control group (specimens were prepared using particle type BCP). A scanning electron microscope study, a compressive strength analysis, and a cytotoxicity assessment were conducted. Graft materials were implanted in each of four circular defects of 6 mm diameter in calvarial bone in seven rabbits. Animals were sacrificed after four weeks for micro-CT and histomorphometric analyses, and the findings obtained were used to calculate new bone volumes (mm3) and area percentages (%). It was found that these two values were significantly higher in the BCP/c-CMC group than in the other three groups (p < 0.05). Within the limitations of this study, BCP composite block bone graft material incorporating crosslinked CMC has potential utility when bone augmentation is needed.

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Stimulation of healing within a rabbit calvarial defect by a PCL/PLGA scaffold blended with TCP using solid freeform fabrication technology

Cited by 93 publications

References 44 publications

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

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