Stimulation of Postprandial Fat Utilization in Healthy Humans by Daily Consumption of Chlorogenic Acids

Abstract

Long-term ingestion of coffee polyphenols (chlorogenic acids, CGAs) reduces body fat in humans and rodents. While CGA supplementation has been shown to increase fat utilization in rodents, evidence in humans is still limited. The present study clarifies the effect of daily CGA consumption on energy metabolism in humans. Eighteen healthy male subjects (36:1 AE 7:4 y of age) participated in a placebo-controlled, doubleblind, crossover, intervention study with two different test beverages. The subjects consumed 185 mL of a test beverage with or without CGAs (329 mg) daily for 4 wk. The energy metabolism was evaluated by using indirect calorimetry before and after the test period during fasting and up to 180 min postprandially. Indirect calorimetry showed that a 4-wk ingestion of the CGA beverage led to a significantly higher postprandial energy expenditure than that of the control beverage. The subjects ingesting the CGA beverage exhibited higher postprandial fat utilization than those consuming the control beverage. The daily CGA consumption therefore increased postprandial fat utilization in healthy humans.

A Comprehensive Overview of the Risks and Benefits of Coffee Consumption

“…Coffee intake (3 × 250 mL/day for 4 weeks) can also decrease energy intake, by improving satiety hormones (ghrelin and serotonin) and therefore decreasing levels of body fat (Bakuradze and others ). Moreover, others have shown that either the mannooligosaccharides (Kumao and Fujii ) or polyphenols (chlorogenic acid; Soga and others ) in coffee can increase or stimulate postprandial fat utilization, thus promoting excretion of fat in the feces.…”

Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults

“…Our previous study demonstrated that dietary supplementation with coffee polyphenols improved energy metabolism and reduced body fat, and these effects were probably due to enhanced fat A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 6 catabolism in the liver [11]. We also demonstrated that the daily ingestion of chlorogenic acids increased fat catabolism in healthy humans [12,13]. However, the relationship between daily ingestion of chlorogenic acids and diabetes or blood glucose and cardiovascular diseases remain unknown.…”

Combined effect of coffee ingestion and repeated bouts of low‐intensity exercise on fat oxidation

“…Apart from the caffeine, polyphenols in both coffee and decaffeinated coffee also enhance energy expenditure and fat oxidation over time (4-15 weeks). However, the underlying mechanisms differ from caffeine in that a single dose of polyphenols is not sufficient to induce an acute effect (Murase et al, 2011;Soga et al, 2013). This accumulated evidence suggests that caffeine plays a role in stimulating an acute increase in energy expenditure.…”