Stimulation of quiescent 3T3 cells by phosphatidic acid-containing liposomes

Siegmann, Deborah W.

doi:10.1016/0006-291x(87)91310-6

Cited by 57 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Addition of PA to Ratl fibroblasts led to DNA synthesis (Moolenaar et al, 1986). PA has been shown to be mitogenic for 3T3 fibroblasts (Siegmann, 1987) and mammary epithelia (Imagawa et al, 1989). Derivatives of PA, particularly lysophosphatidate, are also potent mitogens for fibroblasts (van Corven et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex.

et al. 1991

View full text Add to dashboard Cite

A number of cellular signaling systems are called into play by interaction of the T lymphocyte antigen receptor/CD3 complex with its cognate antigen. Well-described signaling systems include phosphoinositide turnover, tyrosine phosphorylation, protein kinase C activation, and increased cytosolic calcium. We have explored the possibility that another recently described signaling system, activation of phospholipase D, may be operative. Data presented here demonstrate that stimulation of Jurkat T cells with anti-CD3 antibodies or phorbol esters resulted in activation of phospholipase D, as

show abstract

Section: Introductionmentioning

confidence: 99%

Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex.

et al. 1991

View full text Add to dashboard Cite

show abstract

“…PA acts as an effective mediator which has been linked to the survival and proliferation of cells and reproduction of organisms. Indeed, exogenous PA has the same mitogenic and biological effects; including growth stimulation of fibroblasts, induction of mRNA for proto-oncogenes, growth factors, activation of the neutrophil NADPH oxidase, and binding to neutrophils (Moolenaar et al, 1986;Siegmann, 1987;Knauss et al, 1990;Perry et al, 1993). However, the intracellular signaling mechanisms triggered by exogenously added PA are not clear.…”

Section: Introductionmentioning

confidence: 99%

STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells

et al. 2009

View full text Add to dashboard Cite

Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of signaling proteins. We found that Bcl-2 was upregulated by PA treatment in HeLa cells. However, how PA upregulates Bcl-2 expression has not yet been studied. In this study, we tried to discover the mechanisms of

show abstract

“…In this study Moolenaar and his co-workers revealed that LPA derived from phosphatidic acid (PA) was able to act as mitogenic stimulus inducing cell proliferation [6]. The mitogenic activity of PA was previously reported by these authors and others in quiescent normal fibroblasts [7][8][9], but this study showed that among different PA-derived lipids, only LPA exerts a mitogenic effect for quiescent normal cells [6]. It is also noteworthy that the mitogenic effect of LPA was observed in a wide range of cells, including normal and transformed cells.…”

Section: First Discoveries In the Lysophospholipids Fieldmentioning

confidence: 77%

Lysophosphatidylinositol signalling: New wine from an old bottle

Piñeiro

Falasca

2012

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

View full text Add to dashboard Cite

Lysophosphatidylinositol (LPI) is a bioactive lipid generated by phospholipase A2 which is believed to play an important role in several diseases. Indeed LPI can affect various functions such as cell growth, differentiation and motility, in a number of cell-types, including cancer cells, endothelial cells and nervous cells. Despite the fact that LPI-induced cellular functions had been known for more than twenty years, the recent discovery that in several cell-types the orphan G protein-coupled receptor GPR55 acts as the specific receptor for LPI has fuelled novel interest in this lysolipid. Different research groups, including our own, have recently suggested that LPI may be the specific and functional ligand for GPR55, triggering signalling cascades that are relevant to cell proliferation, migration, survival and tumourigenesis. Recently published data suggest that the LPI/GPR55 axis plays an important role in different physiological and pathological contexts. Here we review the available data supporting the role of LPI in cell signalling and the pharmacology of its putative receptor GPR55.

show abstract

Stimulation of quiescent 3T3 cells by phosphatidic acid-containing liposomes

Cited by 57 publications

References 14 publications

Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex.

Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex.

STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells

Lysophosphatidylinositol signalling: New wine from an old bottle

Contact Info

Product

Resources

About