Stimulation of Tear Secretion and Treatment of Dry-Eye Disease With 3-Isobutyl-1-methylxanthine

Gilbard, Jeffrey P.; Rossi, Scott R.; Heyda, Kathleen Gray; Dartt, Darlene A.

doi:10.1001/archopht.1991.01080050086035

Cited by 29 publications

(15 citation statements)

References 15 publications

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“…Tear film osmolarity has been widely reported to have diagnostic value in dry eye disease. [45][46][47] Gilbard et al [48][49][50] have shown an effect of some artificial tears on tear film osmolarity and ocular surface disease in small pilot studies. This study did not show a significant reduction in osmolarity with either emulsion or hypromellose, nor was there a significant difference in the effect of the drops.…”

Section: Discussionmentioning

confidence: 99%

Effect of an Oil-in-Water Emulsion on the Tear Physiology of Patients With Mild to Moderate Dry Eye

Khanal

Tomlinson²,

Pearce³

et al. 2007

Cornea

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Section: Discussionmentioning

confidence: 99%

Effect of an Oil-in-Water Emulsion on the Tear Physiology of Patients With Mild to Moderate Dry Eye

Khanal

Tomlinson²,

Pearce³

et al. 2007

Cornea

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“…It has been shown that topically applied xanthines can stimulate tear production, thereby decreasing tear film osmolarity and relieving dry eye symptoms. 16 Caffeine is a xanthine, which may explain its protective effect. However, whether ingested caffeine has a similar stimulatory effect is not known.…”

Section: Commentmentioning

confidence: 99%

Prevalence of and Risk Factors for Dry Eye Syndrome

Moss

Klein²,

Klein³

2000

Arch Ophthalmol

1,041

704

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To examine risk factors for the prevalence of dry eye syndrome in a population-based cohort. Methods: The prevalence of dry eye was determined by history at the second examination (1993-1995) of the Beaver Dam Eye Study cohort (N = 3722). Results: The cohort was aged 48 to 91 years (mean±SD, 65±10 years) and 43% male. The overall prevalence of dry eye was 14.4%. Prevalence varied from 8.4% in subjects younger than 60 years to 19.0% in those older than 80 years (PϽ.001 for test of trend). Age-adjusted prevalence in men was 11.4% compared with 16.7% in women (PϽ.001). After controlling for age and sex, the following factors were independently and significantly associated with dry eye in a logistic model: history of arthritis (odds ratio [OR],

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“…5,20 Unfortunately, the analysis of lacrimal content could not be carried out in this study because of technical reasons. Nevertheless, therapeutic opportunities such as for the use of lacrimal secretagogues, [21][22][23] or treatment directed towards the restoration of corneal sensory function and sensory drive would be beneficial.…”

Section: Discussionmentioning

confidence: 99%

Topical cyclosporine A for the dry eye findings of thyroid orbitopathy patients

Altiparmak

Acar

Ozer

et al. 2009

Eye

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Purpose To determine the beneficial effect of topically administered Cyclosporine A (CsA) for the dry eye findings of thyroid orbitopathy patients. Patients and methods This prospective pilot study included 73 eyes of 42 patients with thyroid orbitopathy who had documented dry eye findings. Patients were randomly assigned into two groups: in group 1 (48 eyes), patients received topical artificial tear-drop treatment. In group 2 (25 eyes), patients received topical CsA and artificial tear-drop treatment. During a mean follow-up of 6 months, change in Schirmer's test with aneasthesia, tear break-up-time (BUT) and impression cytology results were analyzed and were compared between groups. Results The two groups were age (P ¼ 0.449) and gender (P ¼ 0.942) matched. The Schirmer's test (P ¼ 0.441), tear BUT (P ¼ 0.718) and impression score (P ¼ 0.103) were also similar before the treatment in both groups. In group 1, all three parameters improved significantly with treatment (Po0.001 for all). In group 2, Schirmer's test (P ¼ 0.001) and tear BUT (Po0.001) improved, but the impression score (P ¼ 0.175) did not change significantly after treatment. The percentage of patients with improved tear BUT (P ¼ 0.04) and improved impression score (Po0.001) were higher in group 1. At the end of follow-up, group 1 patients had better Schirmer's test (P ¼ 0.004), tear BUT (P ¼ 0.021) and impression scores (Po0.001), than group 2 patients. Conclusions The combined CsA use with artificial tear drops is not more advantageous than the use of artificial tear drops alone, for the dry eye findings of thyroid orbitopathy patients.

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Stimulation of Tear Secretion and Treatment of Dry-Eye Disease With 3-Isobutyl-1-methylxanthine

Cited by 29 publications

References 15 publications

Effect of an Oil-in-Water Emulsion on the Tear Physiology of Patients With Mild to Moderate Dry Eye

Effect of an Oil-in-Water Emulsion on the Tear Physiology of Patients With Mild to Moderate Dry Eye

Prevalence of and Risk Factors for Dry Eye Syndrome

Topical cyclosporine A for the dry eye findings of thyroid orbitopathy patients

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