Stimulation of the chemotactic migration of human fibroblasts by substance P

Kähler, Christian M.; Sitte, B.; Reinisch, Norbert; Wiedermann, Christian J.

doi:10.1016/0014-2999(93)90523-k

Cited by 64 publications

(32 citation statements)

References 17 publications

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“…Three new articles were retrieved this way, for a total of 13 articles concerning the action of CGRP and/or SP on cultured human skin fibroblasts, of which 12 were related to SP and 1 was related to both CGRP and SP. A summary of the content of these articles is shown in Table 1 [30,[50][51][52][53][54][55][56][57][58][59][60][61]. A schematic drawing is proposed showing the molecular mechanisms of CGRP and SP in human skin fibroblasts and is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…In order to investigate other activities of neuropeptides in the inflammatory processes, a study has assessed the ability of SP to stimulate chemotaxis in human fibroblasts [51]. Kähler et al [52] reported that SP was a potent chemoattractant for human fibroblasts in vitro, triggering a concentration-dependent migratory response. When testing the chemoattractant properties of SP fragments, only the C-terminal fragment analog induced migratory responses [52].…”

Section: Discussionmentioning

confidence: 99%

“…Kähler et al [52] reported that SP was a potent chemoattractant for human fibroblasts in vitro, triggering a concentration-dependent migratory response. When testing the chemoattractant properties of SP fragments, only the C-terminal fragment analog induced migratory responses [52]. It was suggested that chemotactic responsiveness is encoded by the C-terminus of the SP, which is known to be active in NK receptors.…”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that chemotactic responsiveness is encoded by the C-terminus of the SP, which is known to be active in NK receptors. The ability of substance P to promote chemotaxis in human fibroblasts, which extends to the fibroplasia phase of wound healing, is another proinflammatory activity of this neuropeptide [52].…”

Section: Discussionmentioning

confidence: 99%

“…SP also affects the proliferation of skin fibroblasts [52]. A study on the role of SP in the formation of hypertrophic scars has reported that SP increased in vitro proliferation of skin fibroblasts in a dosedependent manner, with maximum rate for an SP concentration of 25 ng mL -1 [58].…”

mentioning

confidence: 99%

See 4 more Smart Citations

The action of CGRP and SP on cultured skin fibroblasts

Hochman

Tucci-Viegas²,

Monteiro

et al. 2014

Open Life Sciences

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show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The action of CGRP and SP on cultured skin fibroblasts

Hochman

Tucci-Viegas²,

Monteiro

et al. 2014

Open Life Sciences

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Modern Aspects of Cutaneous Neurogenic Inflammation

Steinhoff

Ständer²,

Seeliger³

et al. 2003

Arch Dermatol

309

267

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Correlation and Immunolocalization of Substance P Nerve Fibers and Activated Immune Cells in Human Chronic Gastritis

Sipos

Sípos

Altdorfer

et al. 2008

The Anatomical Record

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Neuropeptides are able to modulate cytokine production by macrophages in response to various stimulators and have a major role in inflammation of different organs. Mammalian poly (ADP-ribose) polymerase (PARP) and nuclear factor kappa B (NF-jB) both have been suggested to play a crucial role in inflammatory disorders. Unregulated increase of tumor necrosis factor-a (TNF-a) may also be pathogenic in inflammatory diseases. The aim of this study was to investigate the correlation between the number of Substance P (SP) containing nerve fibers and activated immune cells using immunohisto-, immunocytochemical (EM) and confocal laser microscopic methods. To investigate expression and activation of immune cells gastric biopsy samples from patients with chronic gastritis were used. The number of SP containing nerve fibers and activated immune cells increased significantly in gastritis. Using monoclonal p65 antibody, activated NF-jB was found in inflamed mucosa but was absent in uninflamed mucosa. Immunobinding for the activated form of p65 of NF-jB was found in 22% of macrophages and 45% of lymphocytes. The number of immune cells showing IR for NF-jB, PARP and TNF-a correlated with the increasing number of SP containing fibres. Confocal laser microscopy was used to confirm the colocalization of SP in TNF-a and NFjB positive lymphocytes and mast cells in inflamed mucosa. Immunoelectronmicroscopic investigation confirmed that these cells belong to lymphocytes, mast cells and macrophages. Conclusions: The increase of SP in nerve fibers and in activated immune cells further activate the production of other proinflammatory mediators (e.g. TNF-a) and therefore generate the chronic inflammation.

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Stimulation of the chemotactic migration of human fibroblasts by substance P

Cited by 64 publications

References 17 publications

The action of CGRP and SP on cultured skin fibroblasts

The action of CGRP and SP on cultured skin fibroblasts

Modern Aspects of Cutaneous Neurogenic Inflammation

Correlation and Immunolocalization of Substance P Nerve Fibers and Activated Immune Cells in Human Chronic Gastritis

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