Stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the medial division of adult zebrafish

Ng, Ming Chong; Tang, Tsao Hao; Ko, Meng Chang; Wu, Yao Ju; Hsu, Chun Po; Yang, Yi; Lu, Kwok Tung

doi:10.1016/j.neulet.2012.01.070

Cited by 14 publications

(19 citation statements)

References 24 publications

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“…In addition, FMRP is required for NMDA receptor-dependent LTP in the mouse prefrontal cortex [19]. Our previous work showed that telencephalic LTP at Dl-Dm synapses is NMDAR-dependent [36]. Therefore, we suggest that the reduction of LTP in the present study may be mediated through an NMDAR-dependent pathway.…”

Section: Discussionsupporting

confidence: 51%

“…In a previous study, we reported that the physiological function of the telencephalon is involved in the process of fear memory formation in inhibitory avoidance tasks in zebrafish [34]. Furthermore, electrophysiological evidence has demonstrated that the intratelencephalic connections between the lateral and medial pallium, and the Dl-Dm synapse, play important roles in the synaptic plasticity of the zebrafish [36]. Because our behavioral results suggested that the lack of FMRP caused inhibitory avoidance learning deficits, we hypothesized that FMRP may play an important functional role in telencephalic synaptic plasticity.…”

Section: Discussionmentioning

confidence: 91%

“…LTP is an enduring enhancement of synaptic efficacy that has been reported as a cellular model for learning, memory and neuronal plasticity in mammals [44], [45], [46], [47] and zebrafish [36], [48]. Recently, abnormal LTP of excitatory transmission has been found in the hippocampus [49], cortex [50], [51], and amygdala [19] of fmr1 KO mice.…”

Section: Discussionmentioning

confidence: 99%

“…Acute telencephalic slice preparation was similar to that described previously [36]. Briefly, fish were euthanized by exposing them to an ice-cold (0∼4°C), artificially oxygenated cerebrospinal fluid (aCSF) solution consisting of the following: 117 mM NaCl, 4.7 mM KCl, 1.2 mM NaH 2 PO 4 , 2.5 mM NaHCO 3 , 1.2 mM MgCl 2 , 2.5 mM CaCl 2 , and 11 mM d-(+)-glucose.…”

Section: Methodsmentioning

confidence: 99%

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Behavioral and Synaptic Circuit Features in a Zebrafish Model of Fragile X Syndrome

Yang

2013

PLoS ONE

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Fragile X syndrome (FXS) is the most frequent inherited form of human mental retardation. It is characterized by cognitive impairment and physical and behavioral problems and is caused by the silencing of fmr1 transcription and the absence of the fmr1 protein (FMRP). Recently, animal models of FXS have greatly facilitated the investigation of the molecular and cellular mechanisms of this loss-of-function disorder. The present study was aimed to further characterize the role of FMRP in behavior and synaptic function by using fmr1 knockout zebrafish. In adult zebrafish, we found that fmr1 knockout produces the anxiolytic-like responses of increased exploratory behavior in light/dark and open-field tests and avoidance learning impairment. Furthermore, electrophysiological recordings from telencephalic slice preparations of knockout fish displayed markedly reduced long-term potentiation and enhanced long-term depression compared to wild-type fish; however, basal glutamatergic transmission and presynaptic function at the lateral (Dl) and medial (Dm) division of the dorsal telencephalon synapse remained normal. Taken together, our study not only evaluates the mechanism of FRMP but also suggests that zebrafish have valuable potential as a complementary vertebrate model in studying the molecular pathogenesis of human fragile X syndrome.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Behavioral and Synaptic Circuit Features in a Zebrafish Model of Fragile X Syndrome

Yang

2013

PLoS ONE

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“…Our previous results showed that electrical stimulation in the Dl division could evoke a field potential in the ipsilateral Dm division. In addition, long-term potentiation (LTP) and long-term depression (LTD) were respectively induced by applying high-frequency stimulation (HFS) and low-frequency stimulation (LFS) 9 , 10 . These observations raise the possibility that the activation of the unilateral Dl division may induce synaptic plasticity on both sides of the Dm division.…”

Section: Introductionmentioning

confidence: 99%

Unilateral stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the bilateral medial division of zebrafish

Chen

Tang

et al. 2017

Sci Rep

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This study was aimed to evaluate the synaptic plasticity in projections from the dorsal lateral region (Dl) to the bilateral dorsal medial region (Dm) of the zebrafish telencephalon. The results showed that unilateral electrical stimulation of the Dl evokes a negative field potential (FP) in both the contralateral and ipsilateral side of the Dm. We tested synaptic plasticity, including high-frequency stimulation-induced LTP (HFS-LTP) and low-frequency stimulation-induced LTD (LFS-LTD). We demonstrated that HFS-induced bilateral LTP is NMDAR-dependent by the application of an NMDAR antagonist, DL-AP5 (30 μM, suprafused for 10 min), which blocked the HFS-induced LTP in both the contralateral and ipsilateral Dm. In addition, LTP was restored after DL-AP5 was washed out by continuous aCSF suprafusion. These results suggested that the potentiation is NMDAR-dependent. Either LFS (1 Hz for 20 min) or applying the mGluR agonist, DHPG (40 μM, suprafused for 10 min) successfully induced bilateral LTD for at least 1 h. Furthermore, both the contralateral fEPSP and LTP vanished after ablation of the anterior commissure. In conclusion, the results of the present study suggested that the projection between the Dl and contralateral Dm in the telencephalon of zebrafish is via the anterior commissure and possesses synaptic plasticity.

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Acute administration of THC impairs spatial but not associative memory function in zebrafish

et al. 2014

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Stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the medial division of adult zebrafish

Cited by 14 publications

References 24 publications

Behavioral and Synaptic Circuit Features in a Zebrafish Model of Fragile X Syndrome

Behavioral and Synaptic Circuit Features in a Zebrafish Model of Fragile X Syndrome

Unilateral stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the bilateral medial division of zebrafish

Acute administration of THC impairs spatial but not associative memory function in zebrafish

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