Stimulation of wound healing with laser beam in the rat

Kov⇂s, Iren B.; Mester, E; Görög, P.

doi:10.1007/bf01945182

Cited by 55 publications

(21 citation statements)

References 2 publications

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“…A similar increase in ATP production has been found in rat liver mitochondria after photostimulation with He-Ne laser in vitro [44,45] These metabolic effects result in increased tensile strength of healing skin wounds, as demonstrated by Lam et al [46] and Kovacs et al [47].…”

Section: Effects Of Laser Photostimulationsupporting

confidence: 62%

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Enwemeka

Reddy

2000

LASER THERAPY

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Connective tissue injuries, such as tendon rupture and ligamentous strains, are common. Unlike most soft tissues that require 7-10 days to heal, primary healing of tendons and other dense connective tissues take as much as 6 -8 weeks during which they are inevitably protected in immobilization casts to avoid re-injury. Such long periods of immobilization impair functional rehabilitation and predispose a multitude of complications that could be minimized if healing is quickened and the duration of cast immobilization reduced. In separate studies, we tested the hypothesis that early function, ultrasound, 632.8 nm He-Ne laser, and 904 nm Ga-As laser, when used singly or in combination, promote healing of experimentally severed and repaired rabbit Achilles tendons as evidenced by biochemical, biomechanical, and morphological indices of healing. Our results demonstrate that: (1) appropriate doses of each modality, i.e., early functional activities, ultrasound, He-Ne and Ga-As laser therapy augment collagen synthesis, modulate maturation of newly synthesized collagen, and overall, enhance the biomechanical characteristics of the repaired tendons. (2) Combinations of either of the two lasers with early function and either ultrasound or electrical stimulation further promote collagen synthesis when compared to functional activities alone. However, the biomechanical effects measured in tendons receiving the multi-therapy were similar, i.e., not better than the earlier single modality trials. Although tissue repair processes in humans may differ from that of rabbits, these findings suggest that human cases of connective tissue injuries, e.g., Achilles tendon rupture, may benefit from appropriate doses of He-Ne laser, Ga-As laser, and other therapeutic modalities, when used singly or in combination. Our recent meta-analysis of the laser therapy literature further corroborate these findings.

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Section: Effects Of Laser Photostimulationsupporting

confidence: 62%

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Enwemeka

Reddy

2000

LASER THERAPY

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“…The stimulatory effects of LLLT include the following: [9][10][11][12][13] • Proliferation of macrophages • Proliferation of lymphocytes In addition, there is evidence to support the analgesic effects of LLLT, through an enhanced synthesis of endorphins and bradykinins, decreased c-fi bre activity and altered pain threshold. 14,15 Other research suggests a therapeutic analgesic effect, through the release of serotonin and acetylcholine centrally, and histamine and prostaglandins peripherally, with the use of LLLT.…”

Section: Lasers In Dentistrymentioning

confidence: 99%

Low-level laser use in dentistry

Parker

2007

Br Dent J

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“…1988;Karu 1989). For example, in isolated mitochondria, He-Ne laser irradiation (5 J/ cm 2) caused the elevation of membrane potential and production of ATP (Passarella et al 1984;Belkin et al 1988;Karu 1989), while in isolated fibroblasts with the same radiation an increase in collagen production was observed (Kovacs et al 1974). The effect of low-energy laser irradiation on regeneration processes following trauma has thus far been investigated in the skin and the central peripheral nervous systems.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of muscle regeneration in the rat gastrocnemius muscle by low energy laser irradiation

Weiss

Oron

1992

Anat Embryol

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The effect of low-energy laser (He-Ne) irradiation on the rate of skeletal muscle regeneration after partial excision of the rat gastrocnemius muscle was studied using quantitative histological morphometric methods. The injured zones of the experimental rats were subjected to direct He-Ne laser (632.8 nm wavelength) irradiation (6.0 mW for 2.3 min) immediately following injury and once daily thereafter for 5 days. Muscles that were injured as above and subjected to red or room light irradiation served as a control group. The volume fraction (percent of total volume of injured zone) of the mononucleated cells in the injured zone decreased gradually with time after injury, but more rapidly in the laser irradiated muscles than in the control. At 3 days post-injury the myotubes in the laser-irradiated muscles populated a significantly higher percentage (13.9 +/- 1.1%) of the injured area than in the control muscles (7.8 +/- 1.0%). The volume fraction of the young myofibers in the laser irradiated muscles exceeded 30.6 +/- 2.2% and 49.6 +/- 5.6% at 8 and 11 days post-injury, respectively, while in control muscles these structures comprised only 9.6 +/- 1.0% and 27.2 +/- 3.8% of the injured zone at 8 and 11 days after injury, respectively. It is concluded that He-Ne laser irradiation during the regeneration process promotes muscle maturation in the injured zone following partial excision of the rat gastrocnemius muscle.

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Stimulation of wound healing with laser beam in the rat

Cited by 55 publications

References 2 publications

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Low-level laser use in dentistry

Enhancement of muscle regeneration in the rat gastrocnemius muscle by low energy laser irradiation

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