Stimulatory effect of glycine on human growth hormone secretion

Kasai, Kikuo; Kobayashi, Masami; Shimoda, Shin-Ichi

doi:10.1016/0026-0495(78)90165-8

Cited by 19 publications

(10 citation statements)

References 17 publications

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“…These data show that iv administration of glycine produces a significant and dose-dependent in¬ crease in serum GH level, but not in serum Prl level in normal subjects, and reconfirm our previous report in which glycine (250 ml, 0.3m) was administered per os (Kasai et al 1978). Since glycine is a putative neurotransmitter in mam¬ malian CNS as well as monoamines and GABA (Cutler et al 1971;Bruin et al 1973), this agent, like other neurotransmitters, might act either on CNS structures or directly on the anterior pituitary gland.…”

Section: Discussionsupporting

confidence: 91%

“…On the other hand, amino acids contained in proteins (valine, leucine, theonine, arginine, lysine, histidine, and phenylalanine) also stimulate GH release in man (Knopf et al 1965). We have shown that glycine may exert a stimulating effect on GH release, but not on Prl release, when administered per os in man (Kasai et al 1978).…”

mentioning

confidence: 78%

“…The possible participation of glycine in the control of hypothalamic-pituitary function was first re¬ ported by Kasai et al (1978). From both neurochemical and neurophysiologic studies (Cutler et al 1971;Bruin et al 1973), it has been suggested that glycine might be a neurotransmitter in mam¬ malian central nervous system (CNS), in addition to catecholamines, serotonine and gamma-aminobutyric acid (GABA), etc.…”

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confidence: 99%

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Glycine stimulates growth hormone release in man

Kasai

Suzuki

Nakamura

et al. 1980

Acta Endocrinologica

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The influence of glycine, the simplest amino acid, on pituitary function has been investigated in the present study. Different doses (4, 8 or 12 g) of glycine were intravenously infused over 15 or 30 min in normal subjects. Serum levels of GH (growth hormone) and Prl (prolactin) were measured before and after the infusion, and also blood sugar levels were determined. The dose of 4 or 8 g glycine induced a significant increase in serum GH (P < 0.05 or P< 0.001, respectively); however, a more pronounced and significant increase in serum GH levels was observed after infusion at a dose of 12 g glycine (P < 0.001). It was clearly observed that the dose-dependent GH release to intravenous glycine occurred in normal subjects. On the contrary, serum Prl level was not changed significantly, and blood sugar level was transiently, but significantly (P < 0.05), increased after the infusion of 12 g glycine. The present data suggest that glycine might play an important role in the control of hypothalamic-pituitary function.

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Section: Discussionsupporting

confidence: 91%

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confidence: 78%

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confidence: 99%

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Glycine stimulates growth hormone release in man

Kasai

Suzuki

Nakamura

et al. 1980

Acta Endocrinologica

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“…Indeed, the ability of glycine to increase insulin has not been consistently demonstrated. In the present study and others [3, 11], oral administration of glycine did produce a modest increase in insulin while in 2 other studies glycine did not significantly affect the insulin concentration in healthy subjects [12, 13]. Also, intravenous administration of glycine to 2 overweight subjects did not stimulate an increase in insulin at a high physiologic concentration, but did modestly stimulate an increase in insulin at a supraphysiological concentration [14].…”

Section: Discussionsupporting

confidence: 47%

Interaction of Ingested Leucine with Glycine on Insulin and Glucose Concentrations

Iverson

Gannon

Nuttall

2014

Journal of Amino Acids

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The majority of individual amino acids increase insulin and attenuate the plasma glucose response when ingested with glucose. Objective. To determine whether ingestion of two amino acids simultaneously, with glucose, would result in an additive effect. Leucine (Leu) and glycine (Gly) were chosen because they were two of the most potent glucose-lowering amino acids when given individually. Materials and Methods. Nine subjects received test items on four separate days. The first was a water control, then 25 g glucose, or Leu + Gly (1 mmol/kg fat-free mass each) ±25 g glucose, in random order. Glucose, insulin, and glucagon were measured frequently for 2.5 hours. Net areas were calculated. Results. The glucose area response decreased by 66%. The insulin area response increased by 24% after ingestion of Leu + Gly + glucose compared to ingestion of glucose alone. The decrease in glucose response was not additive; the increase in insulin response was far less than additive when compared to previously published individual amino acid results. The glucagon concentration remained unchanged. Conclusion. There is an interaction between Leu and Gly that results in a markedly attenuated glucose response. This occurred with a very modest increase in insulin response. Changes in glucagon response could not explain the results. The mechanism is unknown.

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“…The scientific literature suggests that growth hormone can be stimulated by the oral intake of the following amino acids: Lysine 1200 mg with arginine 1200 mg [7], 2 grams of glutamine [8], or 5.6 grams of glycine [9]. Since arginine is converted to ornithine, the ornithine in the Generator can be considered like arginine.…”

Section: Igf-1 Peak From Baselinementioning

confidence: 99%

A Pilot Study in Normal Volunteers of the Effects of the Renuva™ System on Growth Hormone and Insulin-Dependent Growth Factor-1

Schumacher¹,

Amen²,

Rood³

et al. 2009

TONUTRAJ

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Background:The Renuva™ System is a dietary supplement sold to prevent symptoms of age-related growth hormone decline.Objective: Test the ability of the Renuva™ System to increase growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Methods:The Renuva™ System is a two-part dietary supplement to maintain a healthy endocrine system. The "Generator Drink" contains amino acids and nicotinic acid. The "Infuser Spray" contains growth hormone releasing peptides in a patented oral delivery system. The Renuva™ System was given to 13 healthy volunteers >40 years. Two of 13 subjects were given just the "Infuser Spray" to swallow, and four subjects were given just the "Generator Drink" on a second occasion. GH and IGF-1 were measured at -10, -5, 0, 30, 60, 90, 120, and 180 minutes.Results: Thirteen subjects receiving the two-part Renuva™ System increased GH 98 + 50.2% (SEM) (p<0.05) from baseline, and IGF-1 rose 35.8 + 45.0 ng/mL (p<0.02) from baseline at 120 minutes. Average IGF-1 levels of 2 subjects receiving just the "Infuser Spray" was less 174.8 + 20.8 ng/ml) than average IGF-1 post-baseline values during the test using both the Infuser Spray and Generator drink (213 + 37.2 ng/mL, p<0.002). Average IGF-1 levels of 4 subjects receiving just the "Generator Drink" was less (202.6 + 124.7 ng/mL) than average IGF-1 post-baseline values when using both the Infuser spray and the Generator drink (234.8 + 32.2 ng/mL, p=NS). Conclusion:The Renuva™ System increases GH and IGF-1. Both the Generator Drink and the Infuser Spray appear to contribute to the increase in IGF-1.

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Stimulatory effect of glycine on human growth hormone secretion

Cited by 19 publications

References 17 publications

Glycine stimulates growth hormone release in man

Glycine stimulates growth hormone release in man

Interaction of Ingested Leucine with Glycine on Insulin and Glucose Concentrations

A Pilot Study in Normal Volunteers of the Effects of the Renuva™ System on Growth Hormone and Insulin-Dependent Growth Factor-1

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