Stimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae on murine haematopoietic stem cells and megakaryocyte progenitors

Vincent‐Naulleau, Silvia; Thibault, D; Neway, T.; Pilet, Charles

doi:10.1016/s0923-2494(97)82484-4

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…A group of polar GPLs from M. chelonae (pGPL-Mc) has also been reported to increase the resistance of mice to disseminated candidiasis [292] and to enhance the immune response to influenza vaccination [293]. Moreover, pGPL-Mc molecules exhibit the properties of haematopoietic growth factor [294][295][296].…”

Section: Biological Properties Of Gplsmentioning

confidence: 99%

Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids

Daffé

Crick

Jackson

2015

Molecular Genetics of Mycobacteria

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This chapter summarizes what is currently known of the structures, physiological roles, involvement in pathogenicity and biogenesis of a variety of non-covalently bound cell envelope lipids and glycoconjugates of Mycobacterium tuberculosis and other Mycobacterium species. Topics addressed in this chapter include phospholipids; phosphatidylinositol mannosides; triglycerides; isoprenoids and related compounds (polyprenyl phosphate, menaquinones, carotenoids, non-carotenoid cyclic isoprenoids); acyltrehaloses (lipooligosaccharides, trehalose mono-and di-mycolates, sulfolipids, di-and poly-acyltrehaloses); mannosyl-beta-1phosphomycoketides; glycopeptidolipids; phthiocerol dimycocerosates, para-hydroxybenzoic acids and phenolic glycolipids; mycobactins; mycolactones; and capsular polysaccharides.

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Section: Biological Properties Of Gplsmentioning

confidence: 99%

Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids

Daffé

Crick

Jackson

2015

Molecular Genetics of Mycobacteria

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“…[5][6][7][8][9][10] Among more than 31 serotypes of MAC reported so far, 11) MAC with serovar 1, 4, 8 and 9 were frequently isolated in AIDS patients, and the cumulative results demonstrated that the serovar 4 was predominant in clinical isolates of AIDS patients. 1,12) Stimulation of human peripheral blood mononuclear cells (PBMC) and MonoMAC 6 cells, a human macrophage cell line, with GPL serovar 4 induced production of cytokines TNF-a, IL-1b and IL-6 as well as lipid mediators prostaglandin E 2 and thromboxane B 2 .…”

Section: -4)mentioning

confidence: 99%

Serotype-Specific Modulation of Human Monocyte Functions by Glycopeptidolipid (GPL) Isolated from Mycobacterium avium Complex

Kano

Doi

Fujita

et al. 2005

Biological & Pharmaceutical Bulletin

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The surface glycopeptidolipids of mycobacteria: structures and biological properties

Chatterjee

Khoo

2001

CMLS, Cell. Mol. Life Sci.

130

153

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One of the most important opportunistic pathogens associated with acquired immunodeficiency syndrome (AIDS) is the M. avium complex. M. avium infections are found in up to 70% of individuals in advanced stages of AIDS. It is apparent that M. avium can replicate in host macrophages and persist for long periods. This group of mycobacteria are distinguished by the presence of unique, highly antigenic, surface-located lipids known as the glycopeptidolipids (GPLs). The GPLs are the chemical basis of the 31 distinct serovars of the M. avium complex, and have also been identified in some other species. The M. avium lipids are immunosuppressive and can induce a variety of cytokines that affect general host responses. Despite extensive chemical characterization of the structures of these GPLs, much work is needed to elucidate the molecular mechanism involved in this complex glycosylation pathway and its genetic basis. The challenges for the future lie in explaining the roles of these copious products in the intracellular life and infectivity of mycobacteria. The intention of our review is to offer a concise account of the structures of the M. avium lipids, their putative roles in the host responses, bacterial physiology and pathogenesis, particularly in immunocompromised patients such as those infected with human immunodeficiency virus (HIV). Advances in chemical synthesis of the various haptenic oligosaccharides are also given to demonstrate how these have helped to define the immunogenic determinants. We believe that future research should involve the creation of conditional mutants defective in these lipids for both functional and biosynthesis studies which will complement biological assays using chemically defined or modified neoglycoconjugates.

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Stimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae on murine haematopoietic stem cells and megakaryocyte progenitors

Cited by 8 publications

References 26 publications

Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids

Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids

Serotype-Specific Modulation of Human Monocyte Functions by Glycopeptidolipid (GPL) Isolated from Mycobacterium avium Complex

The surface glycopeptidolipids of mycobacteria: structures and biological properties

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