Stimulatory effects of short-term calcitonin administration on plasma calcium, magnesium, phosphate, and glucose in juvenile Siberian sturgeon Acipenser baerii

Jafari, Naghmeh; Abdollahpour, Hamed; Falahatkar, Bahram

doi:10.1007/s10695-020-00801-z

Cited by 2 publications

(4 citation statements)

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“…The hormones СT and PTH are known to be vital switchers of calcium homeostasis and deposition/absorption (Guerreiro et al, 2007; Jafari et al, 2020; Suzuki et al, 2000). Both hormones belong to the class of peptide regulators and therefore their exposure time normally lasts for several hours (Bonga et al, 1986; Mukherjee et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Bone calcification rate as a factor of craniofacial transformations in salmonid fish: Insights from an experiment with hormonal treatment of calcium metabolism

Маркевич

Pavlova

Есин

2023

Evolution and Development

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Adaptation to different environments can be achieved by physiological shifts throughout development. Hormonal regulators shape the physiological and morphological traits of the evolving animals making them fit for the particular ecological surroundings. We hypothesized that the artificially induced hypersynthesis of calcitonin and parathyroid hormone mutually influencing calcium metabolism could affect bone formation during early ontogeny in fish imitating the heterochrony in craniofacial ossification in natural adaptive morphs. Conducting an experiment, we found that the long‐standing treatment of salmonid juveniles with high doses of both hormones irreversibly shifts the corresponding hormone status for a period well beyond the time scale for total degradation of the injected hormone. The hormones program the ossification of the jaw suspension bones and neurocranial elements in a specific manner affecting the jaws position and pharingo‐branchial area stretching. These morphological shifts resemble the adaptive variants found in sympatric pelagic and demersal morphs of salmonids. We conclude that solitary deviations in the regulators of calcium metabolism could determine functional morphological traits via transformations in skeletal development.

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Section: Discussionmentioning

confidence: 99%

“…CT and PTH doses per individual were chosen to be x10 relative to the effect‐inducing doses found (Bonga et al, 1986; Chakrabarti & Mukherjee, 1993; Jafari et al, 2020; Mukherjee et al, 2004). Like many other peptide hormones, CT and PTH have a short half‐life in the circulation after injection (Austin & Heath, 1981; Potts Jr et al, 1982).…”

Section: Methodsmentioning

confidence: 99%

Bone calcification rate as a factor of craniofacial transformations in salmonid fish: Insights from an experiment with hormonal treatment of calcium metabolism

Маркевич

Pavlova

Есин

2023

Evolution and Development

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“…Increasing serum levels of 1,25(OH)2D3 and calcium decrease PTH secretion, while increasing serum phosphate levels increase PTH secretion [ 25 ]. In addition to PTH, phosphate levels are mainly regulated by FGF-23, 1,25(OH)2D3, Klotho, and dietary phosphate [ 3 , 22 , 26 , 27 ], while calcitonin also affects phosphate levels [ 4 , 5 ]. PTH, FGF-23, and Klotho decrease serum phosphate levels (by inhibiting renal phosphate reabsorption), while 1,25(OH)2D3 increases serum phosphate levels (by increasing renal phosphate reabsorption, phosphate absorption from the intestine, and phosphate release from the bones) [ 2 , 22 ].…”

Section: Involvement Of Pth and Calcitonin In The Regulation Of Calcium And Phosphate Levelsmentioning

confidence: 99%

“…The main factors that regulate phosphate homeostasis are PTH, fibroblast growth factor 23 (FGF-23), 1,25(OH)2D3, and Klotho [ 3 ]. Calcitonin is also involved in the regulation of phosphate levels [ 4 , 5 ]. PTH is released from the parathyroid glands [ 6 ], while calcitonin is released from thyroid C-cells [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Leko

Pleić

Gunjača

et al. 2021

IJMS

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Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.

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Stimulatory effects of short-term calcitonin administration on plasma calcium, magnesium, phosphate, and glucose in juvenile Siberian sturgeon Acipenser baerii

Cited by 2 publications

References 34 publications

Bone calcification rate as a factor of craniofacial transformations in salmonid fish: Insights from an experiment with hormonal treatment of calcium metabolism

Bone calcification rate as a factor of craniofacial transformations in salmonid fish: Insights from an experiment with hormonal treatment of calcium metabolism

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

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