Stimuli-responsive polymers for anti-cancer drug delivery

Cheng, Wei; Gu, Liuqun; Ren, Wei; Liu, Ye

doi:10.1016/j.msec.2014.05.050

Cited by 126 publications

(62 citation statements)

References 132 publications

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“…Poly(N-isopropylacrylamide) (PNIPAAm) belongs to a group of thermosensitive polymers that is being extensively studied in order to develop novel stimulus-responsive materials for biomedical applications such as anti-cancer drug delivery [1], to develop smart surfaces for the harvesting of cell cultures used in tissue engineering [2], to achieve injectable hydrogels for regional tissue mechanical support purposes [3], to develop scaffolds for tissue engineering applications [4] and so on. Such bright is the future of PNIPAAm that represents one of the most widely investigated stimulus-responsive materials for biomedical applications [5,6].…”

Section: Introductionmentioning

confidence: 99%

Study of the chain microstructure effects on the resulting thermal properties of poly(l-lactide)/poly(N-isopropylacrylamide) biomedical materials

Lizundia

Meaurio

Laza

et al. 2015

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Study of the chain microstructure effects on the resulting thermal properties of poly(l-lactide)/poly(N-isopropylacrylamide) biomedical materials

Lizundia

Meaurio

Laza

et al. 2015

Materials Science and Engineering: C

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“…The recent interest in stimuli-responsive polymers [162][163][164] and the unique properties of micelles containing a PHB core promoted the development of PHB-based stimuliresponsive drug carriers [57,165,166]. Indeed, thermo-or pH-responsive copolymers enable to tune the physico-chemical properties of the micelles and also to modify the drug release profile [167][168][169][170][171].…”

Section: Preparation Methods and Characteristics Of Phb-based Stimulimentioning

confidence: 99%

“…Therefore, the use of pH-responsive copolymers is extremely attractive [165,166,178,179]. Indeed, the decrease of the size of micelles in acidic medium enables the transport of the drug at physiological pH, and subsequently its fast release in the close proximity of tumoral cells, thereby protecting normal cells.…”

Section: Preparation Methods and Characteristics Of Phb-based Stimulimentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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“…Such strategies are based on stimulussensitive disassembly and simultaneous drug release or on stimulus-sensitive cleavage of drug molecules from the polymers or intact polymeric micelles (for review see (Cheng et al 2014;Gao et al 2013)). Stimuli that are exploited may be passive (biological) or active (externally applied).…”

Section: Increased Controlmentioning

confidence: 99%