2008
DOI: 10.1002/cmdc.200800134
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Stimulus Dependence of the Action of Small‐Molecule Inhibitors in the CD3/CD28 Signalling Network

Abstract: Cells in the body are exposed simultaneously to a multitude of various signals. Inside a cell, molecular signalling networks integrate this information into a physiologically meaningful response. Interestingly, in the cellular testing of drug candidates, this complexity is largely ignored. Compounds are tested for cells that are challenged with one stimulus only. The activation of T lymphocytes through engagement of the T cell receptor (TCR)-CD3 complex and CD28 coreceptor is a prominent example for a cellular… Show more

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References 34 publications
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