Stimulus pacing affects the activation of the medial temporal lobe during a semantic classification task: An fMRI study

Tieleman, Ann; Seurinck, Ruth; Deblaere, Karel; Vandemaele, Pieter; Vingerhoets, Guy; Achten, Eric

doi:10.1016/j.neuroimage.2005.02.017

Cited by 24 publications

(10 citation statements)

References 26 publications

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“…This likely reflects the observation that the cerebellum is active during a variety of language paradigms, including word/letter generation, word stem completion, semantic processing, phonological processing, and verbal fluency tasks (Petersen et al 1988(Petersen et al , 1989Ojemann et al 1998;Schlosser et al 1998;Lurito et al 2000;Seger et al 2000;Gurd et al 2002;Hubrich-Ungureanu et al 2002;Noppeney and Price 2002;McDermott et al 2003;Xiang et al 2003;Seki et al 2004;Jansen et al 2005;Tieleman et al 2005;Frings et al 2006;. Activation during language tasks is seen in right posterior regions of the cerebellar hemispheres, particularly lobules VI and VII (see Stoodley and Schmahmann 2009a for review).…”

Section: Cerebellar Activation During Cognitive Tasks Language and Rementioning

confidence: 89%

Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies

Stoodley

Desmond²,

Schmahmann

2013

Handbook of the Cerebellum and Cerebellar Disorders

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Functional imaging studies in healthy subjects report cerebellar activation during a wide range of tasks, from motor execution (finger tapping, motor learning, smooth pursuit eye movements) to higher-level cognitive tasks (Tower of London, working memory paradigms, verbal fluency) in which motor responses are eliminated or controlled for. The anatomical connections between the cerebellum, spinal cord, and sensorimotor and association areas of the cerebral cortex suggest a functional topography exists within the human cerebellum, such that different cerebellar regions are part of distributed spinocerebellar and cerebro-cerebellar circuits. This concept is supported by data from functional imaging studies, in which regional activation patterns differ for sensorimotor vs. cognitive and affective task paradigms. Here these neuroimaging data are reviewed and both cross-task comparisons and within-task topography are considered. The evidence indicates that cerebellar activation patterns are related to the specific demands of a given task, and the localization of the activation patterns reflects the engagement of different cerebro-cerebellar circuits.

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Section: Cerebellar Activation During Cognitive Tasks Language and Rementioning

confidence: 89%

Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies

Stoodley

Desmond²,

Schmahmann

2013

Handbook of the Cerebellum and Cerebellar Disorders

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“…Daselaar et al (2001) showed that it could be applied to assess memory functions. Moreover, the use of a self-paced design allows the intrusion of task-unrelated processes to be minimised in the interval between the response and the occurrence of the next stimulus, such as mind wandering, which is likely to produce task-related deactivation (Binder et al, 1999;Tieleman et al, 2005). This advantage could compensate for the differences in RTs mentioned above.…”

Section: Discussionmentioning

confidence: 99%

The neural bases of the constructive nature of autobiographical memories studied with a self-paced fMRI design

Botzung

Denkova

Ciuciu

et al. 2008

Memory

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In Conway and Pleydell-Pearce's model (2000), autobiographical memories are viewed as transitory mental representations, more often generated in an effortful way. An important claim of the model concerns the dynamic process that evolves over time, from the left prefrontal areas to posterior regions, to retrieve specific memories. The present work aims at investigating, using fMRI, the temporal distribution of effortful autobiographical memory construction. In addition, a self-paced design was implemented to elucidate the question of the timing window required to evoke recollections. The results showed a large pattern of brain regions, which included the two major poles of activation predicted by Conway and Pleydell-Pearce's model. Likewise, we were able to detect the earlier implication of the left dorso-lateral prefrontal cortex, by comparison with posterior structures, which seemed to confirm its involvement in the effortful retrieval process. Finally, the self-paced procedure allowed us to refine the timing window necessary to construct past events.

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“…Verbal fluency, verb-for-noun generation, semantic judgment, and word stem completion tasks reliably activate the cerebellum in healthy populations (Buckner et al, 1995; Desmond et al, 1998; Frings et al, 2006; Gurd et al, 2002, Herholz et al, 1996; Hubrich-Ungureanu et al, 2002; Lurito et al, 2000; McDermott et al, 2003; Noppeney and Price, 2002; Ojemann et al, 1998; Raichle et al, 1994; Schlosser et al, 1998; Seger et al, 2000; Tieleman et al, 2005; Xiang et al, 2003). These studies controlled for articulation or employed paradigms that did not require subjects to verbalize their responses, and found activation in the posterior lobe, including lobules VI and VII (Crus I/II).…”

Section: Neuroimaging In Humansmentioning

confidence: 99%

Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing

Stoodley

Schmahmann

2010

Cortex

1,173

872

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Patients with cerebellar damage often present with the cerebellar motor syndrome of dysmetria, dysarthria and ataxia, yet cerebellar lesions can also result in the cerebellar cognitive affective syndrome, including executive, visual-spatial, and linguistic impairments, and affective dysregulation. We have hypothesized that there is topographic organization in the human cerebellum such that the anterior lobe and lobule VIII contain the representation of the sensorimotor cerebellum; lobules VI and VII of the posterior lobe comprise the cognitive cerebellum; and the posterior vermis is the anatomical substrate of the limbic cerebellum. Here we analyze anatomical, functional neuroimaging, and clinical data to test this hypothesis. We find converging lines of evidence supporting regional organization of motor, cognitive, and limbic behaviors in the cerebellum. The cerebellar motor syndrome results when lesions involve the anterior lobe and parts of lobule VI, interrupting cerebellar communication with cerebral and spinal motor systems. Cognitive impairments occur when posterior lobe lesions affect lobules VI and VII (including Crus I, Crus II, and lobule VIIB), disrupting cerebellar modulation of cognitive loops with cerebral association cortices. Neuropsychiatric disorders manifest when vermis lesions deprive cerebrocerebellar limbic loops of cerebellar input. We consider this functional topography to be a consequence of the differential arrangement of connections of the cerebellum with the spinal cord, brainstem, and cerebral hemispheres, reflecting cerebellar incorporation into the distributed neural circuits subserving movement, cognition, and emotion. These observations provide testable hypotheses for future investigations.

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Stimulus pacing affects the activation of the medial temporal lobe during a semantic classification task: An fMRI study

Cited by 24 publications

References 26 publications

Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies

Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies

The neural bases of the constructive nature of autobiographical memories studied with a self-paced fMRI design

Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing

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