Stimulus Relevance in Eliciting Utilisation Behaviour: Case Study in a Patient with a Caudate Lesion

Rudd, Raymond P.; Maruff, Paul; MacCuspie-Moore, Cressida; Velakoulis, Dennis; Brewer, Warrick J.; Pantelis, Christos

doi:10.1080/135468098396107

Cited by 10 publications

(3 citation statements)

References 17 publications

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“…However, in an imaging study of the ED/ID task, while extra-dimensional shifts were associated with DLPFC function, reversal learning was associated with caudate activation, while the association with orbitofrontal function was not confirmed (Rogers et al 2000). Our findings are, however, consistent with neurological lesions of the OFC or caudate, in which patients' behaviour is strongly influenced or cued by the environment reflecting an inability to modify responses to previously learned stimulus-response associations (Lhermitte et al 1986;Rudd et al 1998). Our findings of a relationship between reversal learning on the set-shifting task and disorganization symptoms and behaviours, independent of working memory, are consistent with hypotheses that these phenomena are related to dysfunction of the circuitry involving orbitofrontal cortex and caudate, namely orbitofrontal-striatal-thalamic systems (Robbins, 1990 ;Pantelis et al 1992 ;Pantelis & Brewer, 1995, 1996, and are consistent with some (Liddle & Morris, 1991), though not all empirical studies (Norman et al 1997 ;Baxter & Liddle, 1998).…”

Section: Attentional Set-shifting Ability and Disorganization Syndromescontrasting

confidence: 49%

Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability

et al. 2004

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The specific relationship between negative symptoms and spatial working memory is consistent with involvement of the dorsolateral prefrontal cortex. The associations between difficulty with set-shifting ability and both disorganization symptoms and behaviours may reflect inability to generalize a rule that had been learned and impaired ability to respond flexibly. The specific relationship of illness duration to set-shifting ability may suggest progressive impairment on some executive tasks. The nature of these relationships and their neurobiological and rehabilitation implications are considered.

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Section: Attentional Set-shifting Ability and Disorganization Syndromescontrasting

confidence: 49%

Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability

et al. 2004

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“…Thus, the chronic ischemia of Moyamoya disease may accentuate the picture of disinhibition and related neuropsychological deficits that are well documented in schizophrenia (Pantelis et al, 2001). Further, abnormal basal ganglia function, that has been described in Moyamoya disease (Kuroda et al, 1995), may also help explain the psychotic symptoms and perhaps the observed medication sensitivity, and has also been linked to stimulus-driven behavior (Rudd et al, 1998).…”

Section: Discussionmentioning

confidence: 95%

Moyamoya disease in a patient with schizophrenia

Lubman

Pantelis

Desmond

et al. 2003

J Int Neuropsychol Soc

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We present the case of a 23-year-old Vietnamese male with a 2-year history of a psychotic illness marked by prominent negative symptoms, fatuousness and disturbed behavior. Neuroimaging revealed a prominent vascular flow void affecting the middle and anterior cerebral arteries, with associated increased collateral supply to the frontal cortex, consistent with Moyamoya disease. Neurological examination was unremarkable; however, neuropsychological assessment revealed significant executive dysfunction, including stimulus-driven behavior. Whilst the diagnosis of schizophrenia and Moyamoya disease may be coincidental, an interaction between the 2 diseases may have led to some of the atypical features of this case, including prominent executive dysfunction and marked sensitivity to psychotropic medication. We discuss the nature of possible interactions between the 2 conditions. This case also highlights the importance of re-evaluating patients with atypical or treatment-resistant psychoses for cerebral pathology.

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“…Pathologies in which such errors are enhanced are revealing. Adults with brain damage in areas such as the frontal lobes can be very prone to inappropriately performing habitual actions elicited by stimuli, such as involuntarily answering someone else’s telephone despite instructions to the contrary (Humphreys & Riddoch, 2003; Rudd et al, 1998; Scepkowski & Cronin-Golomb, 2003). Such patients provide a clear demonstration of how processes governing goal-directed action can operate independently of decision-making processes.…”

mentioning

confidence: 99%

Goal directedness and decision making in infants.

Kenward¹,

Folke²,

Holmberg³

et al. 2009

Developmental Psychology

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The term goal directed conventionally refers to either of 2 separate process types-motor processes organizing action oriented toward physical targets and decision-making processes that select these targets by integrating desire for and knowledge of action outcomes. Even newborns are goal directed in the first sense, but the status of infants as decision makers (the focus here) is unknown. In this study, 24-montholds learned to retrieve an object from a box by pressing a button, and then the object's value was increased. After the object's subsequent disappearance, these children were more likely to press the button to try to retrieve the object than were control 24-month-olds who had learned to retrieve the object but for whom the object's value was unchanged. Such sensitivity to outcome value when selecting actions is a hallmark of decision making. However, 14-and 19-month-olds showed no such sensitivity. Possible explanations include that they had not learned the specifics of the action outcome; they had not acquired the necessary desire; or they had acquired both but did not integrate them to make a decision.

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Stimulus Relevance in Eliciting Utilisation Behaviour: Case Study in a Patient with a Caudate Lesion

Cited by 10 publications

References 17 publications

Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability

Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability

Moyamoya disease in a patient with schizophrenia

Goal directedness and decision making in infants.

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