Stimulus-Specific Adaptation in the Inferior Colliculus of the Anesthetized Rat

Malmierca, Manuel S.; Cristaudo, Salvatore; Pérez-González, David; Covey, Ellen

doi:10.1523/jneurosci.4153-08.2009

Cited by 327 publications

(498 citation statements)

References 53 publications

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“…This, with all caution in comparing different neural scales, makes the RP a possible human electrophysiological counterpart of SSA, with which it shares many properties: both occur without overt attention to sounds, are stimulus-specific, and develop rapidly over multiple timescales (Baldeweg, 2007;Nelken and Ulanovsky, 2007;CostaFaidella et al, 2011). Although SSA literature is overwhelming (Ulanovsky et al, 2003(Ulanovsky et al, , 2004Pérez-González et al, 2005;Reches and Gutfreund, 2008;Anderson et al, 2009;Malmierca et al, 2009;Antunes et al, 2010;Farley et al, 2010;Zhao et al, 2011), to date, no study has attempted to explore SSA-timing interactions. To confirm that an irregular timing dampens the repetition effects on a neuronal scale, further research in animal models tapping the influence of timing predictability in the generation of SSA should prove instructive.…”

Section: Discussionmentioning

confidence: 99%

“…In the auditory system, repetition suppression spans multiple spatial and time scales, as revealed by animal single-cell recordings exhibiting stimulus-specific adaptation (SSA) in cortical and subcortical structures (Ulanovsky et al, 2003(Ulanovsky et al, , 2004Pérez-González et al, 2005;Reches and Gutfreund, 2008;Anderson et al, 2009;Malmierca et al, 2009;Antunes et al, 2010;Farley et al, 2010;Zhao et al, 2011), human long-and middle-latency auditory-evoked potentials (AEP) (Haenschel et al, 2005;Slabu et al, 2010;Costa-Faidella et al, 2011;, and fMRI studies (Mutschler et al, 2010). However, none of the abovementioned studies explored the influence of timing regularity on repetition suppression, a subject lightly tapped in human electrophysiology literature, leading to contradictory findings.…”

Section: Introductionmentioning

confidence: 99%

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Interactions between “What” and “When” in the Auditory System: Temporal Predictability Enhances Repetition Suppression

Costa‐Faidella

Baldeweg²,

Grimm³

et al. 2011

J. Neurosci.

144

140

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Neural activity in the auditory system decreases with repeated stimulation, matching stimulus probability in multiple timescales. This phenomenon, known as stimulus-specific adaptation, is interpreted as a neural mechanism of regularity encoding aiding auditory object formation. However, despite the overwhelming literature covering recordings from single-cell to scalp auditory-evoked potential (AEP), stimulation timing has received little interest. Here we investigated whether timing predictability enhances the experience-dependent modulation of neural activity associated with stimulus probability encoding. We used human electrophysiological recordings in healthy participants who were exposed to passive listening of sound sequences. Pure tones of different frequencies were delivered in successive trains of a variable number of repetitions, enabling the study of sequential repetition effects in the AEP. In the predictable timing condition, tones were delivered with isochronous interstimulus intervals; in the unpredictable timing condition, interstimulus intervals varied randomly. Our results show that unpredictable stimulus timing abolishes the early part of the repetition positivity, an AEP indexing auditory sensory memory trace formation, while leaving the later part (ϳϾ200 ms) unaffected. This suggests that timing predictability aids the propagation of repetition effects upstream the auditory pathway, most likely from association auditory cortex (including the planum temporale) toward primary auditory cortex (Heschl's gyrus) and beyond, as judged by the timing of AEP latencies. This outcome calls for attention to stimulation timing in future experiments regarding sensory memory trace formation in AEP measures and stimulus probability encoding in animal models.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interactions between “What” and “When” in the Auditory System: Temporal Predictability Enhances Repetition Suppression

Costa‐Faidella

Baldeweg²,

Grimm³

et al. 2011

J. Neurosci.

144

140

View full text Add to dashboard Cite

show abstract

“…1). Therefore, this phenomenon has been suggested as a single-unit neural correlate of the detection of unexpected stimuli (i.e., change detection, sometimes known as novelty detection; Ulanovsky et al 2003;Perez-Gonzalez et al 2005;Malmierca et al 2009). …”

Section: Stimulus-specific Adaptationmentioning

confidence: 99%

“…In SSA, we expect a stronger response every time the sequence is switched from one stimulus to the other (lower histogram in (c)) et al 2006), and auditory (Perez-Gonzalez et al 2005) pathways. In the auditory system, neurons sensitive to deviations were found at different levels of the pathway: in the inferior colliculus, the auditory thalamus and the auditory cortex (Malmierca et al 2009;Anderson et al 2009;Farley et al 2010;Antunes et al 2010;Ulanovsky et al 2004). Detailed characterization of SSA in the auditory system revealed that it is highly sensitive to minute deviations from the standard frequency.…”

Section: Stimulus-specific Adaptationmentioning

confidence: 99%

Stimulus-specific adaptation, habituation and change detection in the gaze control system

Gutfreund¹

2012

Biol Cybern

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This prospect article addresses the neurobiology of detecting and responding to changes or unexpected events. Change detection is an ongoing computational task performed by the brain as part of the broader process of saliency mapping and selection of the next target for attention. In the optic tectum (OT) of the barn owl, the probability of the stimulus has a dramatic influence on the neural response to that stimulus; rare or deviant stimuli induce stronger responses compared to common stimuli. This phenomenon, known as stimulus-specific adaptation, has recently attracted scientific interest because of its possible role in change detection. In the barn owl's OT, it may underlie the ability to orient specifically to unexpected events and is therefore opening new directions for research on the neurobiology of fundamental psychological phenomena such as habituation, attention, and surprise.

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“…regains the neural response (Sobotka and Ringo, 1994;Ulanovsky et al, 2003;Katz et al, 2006;Reches and Gutfreund, 2008). This phenomenon has recently attracted scientific interest, particularly in the auditory system (Nelken and Ulanovsky, 2007;Anderson et al, 2009;Malmierca et al, 2009;Farley et al, 2010). It has been suggested to play a role in auditory scene analysis, optimal coding, and novelty detection (Ulanovsky et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Stimulus-Specific Adaptation: Can It Be a Neural Correlate of Behavioral Habituation?

Netser¹,

Zahar²,

Gutfreund³

2011

J. Neurosci.

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Habituation is the most basic form of learning, yet many gaps remain in our understanding of its underlying neural mechanisms. We demonstrate that in the owl's optic tectum (OT), a single, low-level, relatively short auditory stimulus is sufficient to induce a significant reduction in the neural response to a stimulus presented up to 60 s later. This type of neural adaptation was absent in neurons from the central nucleus of the inferior colliculus and from the auditory thalamus; however, it was apparent in the OT and the forebrain entopallium. By presenting sequences that alternate between two different auditory stimuli, we show that this long-lasting adaptation is stimulus specific. The response to an odd stimulus in the sequence was not smaller than the response to the same stimulus when it was first in the sequence. Finally, we measured the habituation of reflexive eye movements and show that the behavioral habituation is correlated with the neural adaptation. The finding of a long-lasting specific adaptation in areas related to the gaze control system and not elsewhere suggests its involvement in habituation processes and opens new directions for research on mechanisms of habituation.

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Stimulus-Specific Adaptation in the Inferior Colliculus of the Anesthetized Rat

Cited by 327 publications

References 53 publications

Interactions between “What” and “When” in the Auditory System: Temporal Predictability Enhances Repetition Suppression

Interactions between “What” and “When” in the Auditory System: Temporal Predictability Enhances Repetition Suppression

Stimulus-specific adaptation, habituation and change detection in the gaze control system

Stimulus-Specific Adaptation: Can It Be a Neural Correlate of Behavioral Habituation?

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