Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats

Agussalim, .; Umami, Nafiatul; Nurliyani, Nurliyani; Agus, Ali

doi:10.1016/j.sjbs.2022.103404

Cited by 8 publications

(26 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As reported by some studies, the anti‐inflammatory activity of stingless bee honey samples is related to the content of phenolic compounds and flavonoids, such as quercetin, which act by reducing the expression levels of pro‐inflammatory cytokines such as IL‐ 6, interleukin‐2p70 (IL‐2p70), TNF‐α and IFN‐γ and the anti‐inflammatory cytokine IL‐10, in addition to inhibiting the generation of inflammatory mediators such as cyclooxygenase – 2 (COX‐2) and inducible nitric oxide synthase (iNOS), cytokine production, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and ROS [100,101] …”

Section: Resultsmentioning

confidence: 99%

Chemical Profile and Biological Potential of Scaptotrigona Bee Products (Hymenoptera, Apidae, Meliponini): An Review

de Sousa Silveira,

Silva Macêdo,

de Menezes Dantas

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Stingless bees belong to the Meliponini tribe and are widely distributed in the tropics and subtropics, where they perform important ecological services. Among the best distributed groups of stingless bees is the genus Scaptotrigona, which includes 22 species distributed throughout the neotropical region, including the area from Mexico to Argentina. Bees of this genus are responsible for the production of products such as honey, propolis, geopropolis and fermented pollen (“saburá”). This review aimed to provide an overview of the chemical composition and biological activities associated with derived products from stingless bees of the genus Scaptotrigona. The bibliographic review was carried out through searches in the Scopus, Web of Science, ScienceDirect and PubMed databases, including publications from 2003 to January 2023. The study of the chemodiversity of products derived from Scaptotrigona demonstrated the mainly presence of flavonoids, phenolic acids, terpenoids and alkaloids. It was also demonstrated that products derived from bees of the genus Scaptotrigona exhibit a wide range of biological effects, such as antibacterial, antioxidant, anti‐inflammatory and antifungal activities, among other bioactivities. This review provides an overview of phytochemical and pharmacological investigations of the genus Scaptotrigona. However, it is essential to clarify the toxicity and food safety of these products.

show abstract

Section: Resultsmentioning

confidence: 99%

Chemical Profile and Biological Potential of Scaptotrigona Bee Products (Hymenoptera, Apidae, Meliponini): An Review

de Sousa Silveira,

Silva Macêdo,

de Menezes Dantas

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…There is evidence for the presence of certain compounds (yet unnamed or uncharacterized) capable of stimulating immune responses, such as modulation of cytokine production, triggering of tissue repair cascades, and activation of infections-specific responses (Majtan, 2014;Minden-Birkenmaier & Bowlin, 2018;Molan & Rhodes, 2015;Yaghoobi et al, 2013). On the other hand, a large number of researchers highlight that the multiple and complex interactions with these compounds could induce an excessive inflammatory immune response by certain cytokines' production, as suggested in studies involving COVID-19 and lipopolysaccharide-induced inflammatory response (Agussalim et al, 2022;Biluca et al, 2020;Mustafa et al, 2020;Ooi et al, 2021;Ranneh et al, 2019).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antimicrobial activity of stingless bee honey (Tribe: Meliponini) on clinical and foodborne pathogens: A systematic review and meta‐analysis

Cabezas‐Mera,

Cedeño‐Pinargote,

Tejera

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Honey produced by stingless bees (Tribe: Meliponini) is well‐known for their medicinal and antimicrobial properties from their diverse content of bioactive compounds. However, it has not been possible to fully characterize its active principles. The present systematic review is based on 117 full‐text articles. Our review highlights (1) the need to apply complementary methodologies and consolidate protocols to quantify antimicrobial activity (2) to characterize antimicrobial agents in honeys of Heterotrigona itama, Tetragonisca angustula, and Melipona beecheii, and; (3) to search for compounds against multidrug‐resistant and/or biofilm‐forming pathogens. Moreover, we performed a meta‐analysis of 29 articles with quantitative data using diffusion assays and minimum inhibitory concentration (MIC). Staphylococcus aureus and Escherichia coli were the most evaluated pathogens, evidencing 221 and 149 antimicrobial activity assays against honey samples of 36 and 24 stingless bee species, respectively. The highest pooled mean in diffusion assays against S. aureus showed a difference between methicillin‐resistant S. aureus (MRSA) and non‐MRSA strains {14.43 [95% confidence interval (CI): 12.16–16.71] mm vs. 11.55 (95% CI: 10.22–12.87) mm}, whereas E. coli showed pooled means of 9.09 (95% CI: 7.93–10.25) mm. Regarding MIC expressed as volume/volume percentage (%, v/v), the estimated inhibitory concentrations were 7.89 (95% CI: 3.94–11.83) mL/100 mL for MRSA and 5.60 (95% CI: 2.66–8.55) mL/100 mL considering all S. aureus strains. In contrast, the estimated MICs as weight/volume percentage (%, w/v) showed 15.00 [(95% CI: 12.84–17.16) g/100 mL for S. aureus and 16.17 (95% CI: 5.78–26.55) g/100 mL for E. coli. However, honey remains an unexplored source of antimicrobial molecules.

show abstract

“…Además, han relacionado el papel inmunomodulador con la capacidad antioxidante de la miel en un modelo de rata con desnutrición. Para ello, administraron por vía oral 1.8 g de miel al día por kg de peso del animal durante 7 semanas y observaron un incremento en la producción de células del sistema inmune, una disminución de marcadores pro-inflamatorios y una elevada capacidad antioxidante de la miel, sugieriendo estos hallazgos un papel benéfico de la miel en animales con defensas inmunitarias bajas [77].…”

Section: Actividad Antioxidanteunclassified

La miel de abejas sin aguijón: una medicina diferente

Hernández-Zavala

Gavilanes²,

Castillo³

2023

Epistemus

View full text Add to dashboard Cite

Los principales polinizadores de la flora silvestre son las abejas sin aguijón y los productos del nido como el polen recolectado, el propóleo y principalmente la miel; han sido empleados en la dieta diaria y aún mejor en la medicina tradicional. Empleando palabras clave como: actividad antimicrobiana, antioxidante, antibacteriana y anticancerígena se realizó una búsqueda bibliográfica en libros y artículos de investigación de los buscadores científicos PubMed, World Wide Science, Google Scholar y Springer Link, para describir aspectos generales y ejemplos de los beneficios en la salud de la miel. Estudios in vitro e in vivo han demostrado una relación positiva entre las características fisicoquímicas y la composición fitoquímica de la miel con el efecto benéfico en el tratamiento de afecciones leves como cicatrización de heridas, hasta procesos complejos de inflamación, estrés oxidativo, o infecciones microbianas. Así, la miel de abejas sin aguijón representa un producto con potencial terapéutico.

show abstract

Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats

Cited by 8 publications

References 54 publications

Chemical Profile and Biological Potential of Scaptotrigona Bee Products (Hymenoptera, Apidae, Meliponini): An Review

Chemical Profile and Biological Potential of Scaptotrigona Bee Products (Hymenoptera, Apidae, Meliponini): An Review

Antimicrobial activity of stingless bee honey (Tribe: Meliponini) on clinical and foodborne pathogens: A systematic review and meta‐analysis

La miel de abejas sin aguijón: una medicina diferente

Contact Info

Product

Resources

About