1999
DOI: 10.1111/j.1528-1157.1999.tb02048.x
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Stiripentol: Efficacy and Tolerability in Children with Epilepsy

Abstract: Summary:Purpose: Stiripentol (STP) is a new antiepileptic drug (AED) that inhibits cytochrome P,,,, resulting in increased plasma concentrations of concomitant AEDs. The efficacy and tolerability of STP as an add-on therapy in children were assessed.Methods: Two hundred twelve patients with refractory epilepsy, aged from 1 month to 20.5 years, received STP either in a single-blind, placebo-controlled trial (I08 patients) or in a further open trial (104 other patients selected by epilepsy syndrome for possible … Show more

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Cited by 141 publications
(110 citation statements)
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References 27 publications
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“…+ [59,62] + [44] + [34,48] + [41] Dyskinesia/choreoathetosis Myoclonus + [64] + [59,65] Tics + [53] + [66] Paraesthesia + [37] Headache + [32] + [33,44] + [47,48] + [41] + [36,49,52] + [50] Constipation + [38,50] Diarrhoea + [52] + [50] Abdominal pain…”
Section: Most Frequent Dose-related Adverse Effects To Antiepileptic mentioning
confidence: 99%
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“…+ [59,62] + [44] + [34,48] + [41] Dyskinesia/choreoathetosis Myoclonus + [64] + [59,65] Tics + [53] + [66] Paraesthesia + [37] Headache + [32] + [33,44] + [47,48] + [41] + [36,49,52] + [50] Constipation + [38,50] Diarrhoea + [52] + [50] Abdominal pain…”
Section: Most Frequent Dose-related Adverse Effects To Antiepileptic mentioning
confidence: 99%
“…+ [50] Nausea + [51] + [53] + [62] + [44] + [34,47] + [41][42][43] + [37] + [38] Vomiting + [39] + [32] + [44] + [34,47,48] + [41,42] + [50] Continued next page…”
Section: Most Frequent Dose-related Adverse Effects To Antiepileptic mentioning
confidence: 99%
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“…4,8 STP is available as capsules and as sachets for preparing an oral suspension, both at 250 mg and 500 mg.…”
Section: Drug Interactions and Dosingmentioning
confidence: 99%