Stochastic simulation of the FDA centrifugal blood pump benchmark

Karimi, Mohamad Sadeq; Razzaghi, Pooya; Raisee, Mehrdad; Hendrick, Patrick; Nourbakhsh, Ahmad

doi:10.1007/s10237-021-01482-0

Cited by 13 publications

(6 citation statements)

References 46 publications

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“…Contrarily, the relative velocity in a rotating region is referred to the moving walls in order to detect zones of recirculating flow. Thus, the relative velocity in the rotating region is represented in the MRF, and the discontinuity in the velocity field detected at the interface between rotating and static regions is due to the change from moving to stationary reference frames (Karimi et al 2021 ). It must be noted that the colormap in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the USA Food and Drug Administration (FDA) developed a benchmark centrifugal blood pump to be tested and modeled by multiple research groups in order to use it as a validation tool and standardize the use of CFD in the investigation of blood pumps. Both experimental (Hariharan et al 2018 ) and computational (Good and Manning 2020 ; Karimi et al 2021 ) studies of the FDA blood pump have been carried out to evaluate CFD models and validate them using measurement data collected by different laboratories.…”

Section: Introductionmentioning

confidence: 99%

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Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3

Gil

Navarro

Quintero

et al. 2023

Biomech Model Mechanobiol

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Mechanical circulatory support using ventricular assist devices is a common technique for treating patients suffering from advanced heart failure. The latest generation of devices is characterized by centrifugal turbopumps which employ magnetic levitation bearings to ensure a gap clearance between moving and static parts. Despite the increasing use of these devices as a destination therapy, several long-term complications still exist regarding their hemocompatibility. The blood damage associated with different pump designs has been investigated profoundly in the literature, while the hemodynamic performance has been hardly considered. This work presents a novel comparison between the two main devices of the latest generation–HVAD and HM3–from both perspectives, hemodynamic performance and blood damage. Computational fluid dynamics simulations are performed to model the considered LVADs, and computational results are compared to experimental measurements of pressure head to validate the model. Enhanced performance and hemocompatibility are detected for HM3 owing to its design incorporating more conventional blades and larger gap clearances.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3

Gil

Navarro

Quintero

et al. 2023

Biomech Model Mechanobiol

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“…The computational domain contains one rotational domain and two stationary domains. Based on the numerical simulation study of the blood pump [ 17 , 44 , 45 , 46 , 47 ], the multiple reference coordinate system (MRF) was selected, in which the impeller domain was the rotational coordinate system, and the inlet domain and the worm-casing domain were the stationary coordinate systems. The surfaces overlapping between the three computational domains were set as interfaces.…”

Section: Methodsmentioning

confidence: 99%

Optimization of a Screw Centrifugal Blood Pump Based on Random Forest and Multi-Objective Gray Wolf Optimization Algorithm

et al. 2023

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The centrifugal blood pump is a commonly used ventricular assist device. It can replace part of the heart function, pumping blood throughout the body in order to maintain normal function. However, the high shear stress caused by the impeller rotating at high speeds can lead to hemolysis and, as a consequence, to stroke and other syndromes. Therefore, reducing the hemolysis level while ensuring adequate pressure generation is key to the optimization of centrifugal blood pumps. In this study, a screw centrifugal blood pump was used as the research object. In addition, pressure generation and the hemolysis level were optimized simultaneously using a coupled algorithm composed of random forest (RF) and multi-objective gray wolf optimization (MOGWO). After verifying the prediction accuracy of the algorithm, three optimized models were selected and compared with the baseline model in terms of pressure cloud, 2D streamline, SSS distribution, HI distribution, and vortex distribution. Finally, via a comprehensive evaluation, the optimized model was selected as the final optimization design, in which the pressure generation increased by 24% and the hemolysis value decreased by 48%.

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“…Based on Equations 1 and 2, an accurate velocity field is needed to obtain a reliable prediction of HI (Karimi et al 2021). On the other hand, the non-linearity of Equation 2implies that the HI at the domain outlet cannot be calculated as the sum of local values of HI based on the scalar shear stress and the residence time of RBCs in each grid cell (Wu et al 2021).…”

Section: )mentioning

confidence: 99%

“…As the flow rate increases, additional recirculation zones appear in the external wall of the impeller, at the adjacent blade of each channel. Note that the discontinuity in the velocity field at the interface between rotating and static regions is due to the change from moving to stationary reference frames (Karimi et al 2021).…”

Section: Pump's Operating Mapmentioning

confidence: 99%

CFD analysis of the HVAD’s hemodynamic performance and blood damage with insight into gap clearance

Gil

Navarro

Quintero

et al. 2022

Biomech Model Mechanobiol

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Mechanical circulatory support using ventricular assist devices has become commonplace in the treatment of patients suffering from advanced stages of heart failure. While blood damage generated by these devices has been evaluated in depth, their hemodynamic performance has been investigated much less. This work presents the analysis of the complete operating map of a left ventricular assist device, in terms of pressure head, power and efficiency. Further investigation into its hemocompatibility is included as well. To achieve these objectives, computational fluid dynamics simulations of a centrifugal blood pump with a wide-blade impeller were performed. Several conditions were considered by varying the rotational speed and volumetric flow rate. Regarding the device's hemocompatibility, blood damage was evaluated by means of the hemolysis index. By relating the hemocompatibility of the device to its hemodynamic performance, the results have demonstrated that highest hemolysis occurs at low flow rates, corresponding to operating conditions of low efficiency. Both performance and hemocompatibility are affected by the gap clearance. An innovative investigation into the influence of this design parameter has yielded decreased efficiencies and increased hemolysis as the gap clearance is reduced. As a further novelty, pump operating maps were non-dimensionalized to highlight the influence of Reynolds number, which allows their application to any working condition. The pump's operating range places it in the transitional regime between laminar and turbulent, leading to enhanced efficiency for the highest Reynolds number.

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Stochastic simulation of the FDA centrifugal blood pump benchmark

Cited by 13 publications

References 46 publications

Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3

Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3

Optimization of a Screw Centrifugal Blood Pump Based on Random Forest and Multi-Objective Gray Wolf Optimization Algorithm

CFD analysis of the HVAD’s hemodynamic performance and blood damage with insight into gap clearance

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