Stoffwechsel der Lipide in der Leber

Oette, K.

doi:10.1007/978-3-642-81227-9_15

Zusammenarbeit Von Klinik Und Klinischer Chemie

1978

DOI: 10.1007/978-3-642-81227-9_15

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Stoffwechsel der Lipide in der Leber

K. Oette¹

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1985

1986

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Cited by 2 publications

References 27 publications

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Effects of linolenic and eicosapentaenoic acids on prostaglandin biosynthesis and platelet function in man

Adam¹,

Wolfram²,

Zöllner³

1986

Klin Wochenschr

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Platelet aggregation, bleeding time, prostaglandin biosynthesis and plasma cholesterol fatty acids were investigated in 12 healthy females (25-32 years), who were given different amounts of linolenic acid (0%, 4%, 8%, 12%, 16% of total energy intake) or eicosapentaenoic acid (1.7%) with formula diets for 2 weeks each. Linolenic and eicosapentaenoic acids prolonged the bleeding time and inhibited platelet aggregation and prostaglandin biosynthesis. These effects became apparent after a linolenic acid intake of 12% of the energy intake. A decrease in PGE in 24 h urine was observed after intake of linolenic acid amounting to 8% of energy intake. Eicosapentaenoic acid influenced all parameters measured ten times more than linolenic acid. Linolenic acid intake had no effect on the ratio of linoleic/arachidonic acids in plasma cholesterol esters in contrast to in vitro findings. Thus energy intake comprising 1.7% of eicosapentaenoic acid is sufficient to affect thrombocyte function in man. The concomitant intake of linolenic-type fatty acids inhibits the biosynthesis of prostaglandins E2 and F2 alpha to different degrees.

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Effects of linolenic and eicosapentaenoic acids on prostaglandin biosynthesis and platelet function in man

Adam¹,

Wolfram²,

Zöllner³

1986

Klin Wochenschr

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show abstract

Metabolism of essential fatty acids and prostaglandin biosynthesis in man

Adam¹

1985

Klin Wochenschr

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Linoleic and linolenic acids are precursors for the biosynthesis of prostaglandins (PG) and related compounds. In man augmented linoleic acid intake results in stimulation of PG-biosynthesis, for PG originating from the kidney a stimulation only is found for PGE2. Dietary linolenic acid inhibits PG biosynthesis to a tenfold lesser degree than eicosapentaenoic acid. Renal PGE2 is depressed by linolenic acid intake, while no effect is found for PGF2 alpha up to 8 energy% of linolenic acid supply. Linoleic and linolenic acids additionally display effects on fatty acid metabolism. In contrast to the results of in vitro studies the supply with the precursor linoleic acid results in a decrease of arachidonic acid in cholesterolesters of plasma and in HDL-lecithin, while the intake of linolenic acid is without effect. From these data it is concluded that in vivo the conversion of linoleic to arachidonic acid occurs preferentially to the analogous conversion of linolenic to eicosapentaenoic acid.

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Stoffwechsel der Lipide in der Leber

Cited by 2 publications

References 27 publications

Effects of linolenic and eicosapentaenoic acids on prostaglandin biosynthesis and platelet function in man

Effects of linolenic and eicosapentaenoic acids on prostaglandin biosynthesis and platelet function in man

Metabolism of essential fatty acids and prostaglandin biosynthesis in man

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