Stomatitis after Chemotherapy

Bruya, Margaret Auld; Madeira, Nancy Powell

doi:10.2307/3423621

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the cited studies, patients in the study group developed severe OM less often, required less intensive and shorter analgesic treatment, and avoided the need for TPN. This leads to the hypothesis that it is advisable to conduct further randomized studies examining the beneficial effects of cryotherapy on OM caused also by other medications, including MTX [40][41][42][43].…”

Section: Laser Therapymentioning

confidence: 99%

Methotrexate-associated oral mucositis in children with acute lymphoblastic leukemia

Pustelnik,

Pikora,

Pawelec

2023

Nowotwory. Journal of Oncology

View full text Add to dashboard Cite

Methotrexate is an antifolate widely used in oncology and rheumatology that plays an important role in the treatment of acute lymphoblastic leukemia in children. One of its most common side effects is oral mucositis, which is a general term for ulceration and inflammation of the mucous membrane of the mouth. It can severely affect a patient's quality of life, causes poor nutrition, and may lead to discontinuation of the next course of chemotherapy. Oral mucositis typically develops a few days after chemotherapy infusion. Due to this risk, it appears reasonable to use preventive agents against oral mucositis before the inclusion of methotrexate in therapy. To date, clinical trials have examined the effectiveness of medications such as glutamine, palifermin, chlorhexidine, amifostine, cyclooxygenase-1 inhibitor, leucovorin or other methods including laser therapy and oral cryotherapy. There are also several methods used to control already established inflammation and reduce pain more effectively: laser therapy, platelet-rich plasma and platelet gel, taxifolin, film-forming and coating agents. A crucial role is played by supportive interventions involving analgesic treatment, including topical morphine and benzydamine and a modern approach to pain management -for example, the use of virtual reality.

show abstract

Section: Laser Therapymentioning

confidence: 99%

Methotrexate-associated oral mucositis in children with acute lymphoblastic leukemia

Pustelnik,

Pikora,

Pawelec

2023

Nowotwory. Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…De maneira semelhante às alterações induzidas por quimioterapia as lesões ulcerativas da boca e orofaringe, após radioterapia, desenvolvem-se após 7 a 14 dias do início do tratamento 16 . Al-Tikriti et al 17 avaliaram pacientes portadores de câncer oral com irradiação direta e verificaram que após uma semana os pacientes já apresentavam diminuição do fluxo salivar, algum eritema e dores com intensificação da severidade destas alterações após a terceira semana.…”

Section: Discussão Discussão Discussão Discussão Discussãounclassified

Efeito da clorexidina na mucosite induzida por radioterapia em câncer de cabeça e pescoço

Labbate

Lehn

Denardin

2003

Rev. Bras. Otorrinolaringol.

View full text Add to dashboard Cite

A radioterapia em pacientes com neoplasias de Cabeça e Pescoço causa alterações na mucosa oral comprometendo a execução terapêutica e o resultado final. OBJETIVO: Avaliar o efeito protetor do gluconato de clorexidina, sobre a mucosa oral, durante o tratamento actínico fracionado e o seu reflexo na qualidade de vida referida pelos pacientes. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram selecionados 21 portadores de câncer de Cabeça e Pescoço alocados em dois grupos: grupo Placebo (n=11, 9H e 2M, idade média 58 anos) água destilada - dois bochechos diários e grupo Medicação (n=10, 7H e 2M, idade média 52 anos) gluconato de clorexidina a 0,12% - dois bochechos diários. Os pacientes foram avaliados semanalmente com exame local para detecção das alterações de mucosa (classificação de acordo com a WHO e Grupo de Terapia por Radiação em Oncologia - graus 0 a IV) e preenchimento de questionário de qualidade de vida ressaltando os aspectos de dor, apetite, paladar e hábitos alimentares. A análise estatística realizada pelo teste exato de Fisher. RESULTADOS: A graduação da mucosite foi mais intensa no grupo Placebo em 6 das 10 semanas de avaliação. A freqüência e intensidade das dores foram piores no grupo Placebo na 4ª semana de radioterapia e a modificação de paladar foi mais intensa nos indivíduos que não usavam o medicamento apenas na 7ª semana. Não foram encontradas diferenças nos outros parâmetros de qualidade de vida. CONCLUSÃO: Podemos concluir que o gluconato de clorexidina não eliminou as lesões de mucosa mas diminuiu, significativamente, os seus efeitos deletérios e intensidade sem apresentar um reflexo persistente na qualidade de vida dos pacientes.

show abstract

“…The tool was used to evaluate the effectiveness of lemon and glycerin as an oral hygiene agent for nursing home residents. Bruya and Madeira (1975) were the first nurses to publish a tool for assessing chemotherapy-induced stomatitis. This tool was a 17-item scale (physical state of the patient [level of consciousness, breathing habits, nutritional status, chewing ability, self-care ability]; lips and tongue for texture, colour and moisture; mucous membranes, gingival tissue, teeth, saliva, taste and voice).…”

Section: Literature Reviewmentioning

confidence: 99%

Assessing stomatitis: Refinement of the Western Consortium for Cancer Nursing Research (WCCNR) stomatitis staging system

Olson

Davies

Degner

et al. 1998

CONJ

View full text Add to dashboard Cite

The purpose of this study was to refine the Western Consortium for Cancer Nursing Research (WCCNR) stomatitis staging system. Fifty-six adult cancer patients were accrued. Using all eight descriptors, 96.4% of the participants were correctly staged. Using only lesions, colour and bleeding, however, 92.9% of the cases were correctly staged. Based on the findings of this study, the WCCNR stomatitis staging system has been shortened to include only lesions, colour and bleeding. The significance of stomatitis as a result of cancer therapy was recognized by the National Institute of Health Consensus Development Conference (1990). Incidence levels range from 10% to 97% in patients receiving stomatotoxic chemotherapy protocols (Barrett, 1987; Morry, 1984; Seto, Kim, Wolinsky, Mito & Champlin, 1985). A survey of cancer nurses in Canada identified the prevention and treatment of chemotherapy-induced stomatitis as the top research priority (Western Consortium for Cancer Nursing Research, 1987). The WCCNR, a group comprised of one academically-based individual and one clinically-based individual from each of the four western Canadian provinces, was interested in developing interventions for the prevention and management of stomatitis, but was hampered by the lack of a valid and reliable assessment tool.

show abstract

Stomatitis after Chemotherapy

Cited by 6 publications

References 0 publications

Methotrexate-associated oral mucositis in children with acute lymphoblastic leukemia

Methotrexate-associated oral mucositis in children with acute lymphoblastic leukemia

Efeito da clorexidina na mucosite induzida por radioterapia em câncer de cabeça e pescoço

Assessing stomatitis: Refinement of the Western Consortium for Cancer Nursing Research (WCCNR) stomatitis staging system

Contact Info

Product

Resources

About