Stored Packed Red Blood Cell Transfusion Up-regulates Inflammatory Gene Expression in Circulating Leukocytes

Escobar, Guillermo A.; Cheng, Aaron M.; Moore, Ernest E.; Johnson, Jeffrey L.; Tannahill, Cynthia L.; Baker, Henry V.; Moldawer, Lyle L.; Banerjee, Anirban

doi:10.1097/01.sla.0000264507.79859.f9

Cited by 66 publications

(45 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These reactions include elevated level of mediators such as IL-6 or IL-10 [15] and increased leukocyte activation (reviewed in [16]). Additional experiments revealed that the expression of inflammatory genes in leukocytes is enhanced after incubation with packed RBCs ex vivo in vitro [17]. In the present work, it was demonstrated that dendritic cells are also somehow affected.…”

Section: And Pdc In Dependency Of the Injury Patternmentioning

confidence: 81%

Significant Decline of Peripheral Myeloid Dendritic Cells Following Multiple Trauma

Henrich

Maier

Relja

et al. 2009

Journal of Surgical Research

View full text Add to dashboard Cite

Section: And Pdc In Dependency Of the Injury Patternmentioning

confidence: 81%

Significant Decline of Peripheral Myeloid Dendritic Cells Following Multiple Trauma

Henrich

Maier

Relja

et al. 2009

Journal of Surgical Research

View full text Add to dashboard Cite

“…Transfusion is a potent stimulus for inflammatory gene expression after trauma (73,74). The administration of fresh-frozen plasma has also been linked to ARDS and an increased risk of organ dysfunction (75).…”

Section: Other Iatrogenic Determinants Of the State Of Critical Illnessmentioning

confidence: 99%

Critical illness is an iatrogenic disorder

Marshall¹

2010

Critical Care Medicine

View full text Add to dashboard Cite

Iatrogenic illnesses are those that arise as a result of the process of medical care and are potentially preventable by improvements to patient care. The term is commonly used to denote medical error; however, for the critically ill patient the term has a much more fundamental meaning. Critical illness is inherently iatrogenic: it only develops in those patients who have been resuscitated from an otherwise life-threatening disorder, and its subsequent evolution is shaped by the beneficial and adverse consequences of therapeutic and supportive interventions. The construct of organ dysfunction describes both the nature of this support and its inadvertent consequences. This review explores evolving evidence on the iatrogenic nature of critical illness and the implications of an iatrogenic model of disease on the taxonomy, management, and prevention of the complex processes that threaten to limit the survival of the critically ill patient.

show abstract

“…Other possible mechanisms for the contribution of transfusion to ischemic complications include pro-inflammatory effects, for example by activation of inflammatory genes (such as upregulation of IL-8 and Toll-like receptor 4 or circulating leukocytes [41]), as well as storage defects. In this context, leukocytes have also been reported to accelerate the rate of storage lesions [42].…”

Section: Impact Of Storage Time On Quality Of Red Blood Cell Unitsmentioning

confidence: 99%

Our own blood is still the best thing to have in our veins

Frenzel

Aken

Westphal

2008

Current Opinion in Anaesthesiology

View full text Add to dashboard Cite

Stored Packed Red Blood Cell Transfusion Up-regulates Inflammatory Gene Expression in Circulating Leukocytes

Abstract: PRBCs activate inflammatory genes in circulating leukocytes, which may be central to the pathogenesis of the adverse inflammatory responses that lead to postinjury MOF.

Cited by 66 publications

References 35 publications

Significant Decline of Peripheral Myeloid Dendritic Cells Following Multiple Trauma

Significant Decline of Peripheral Myeloid Dendritic Cells Following Multiple Trauma

Critical illness is an iatrogenic disorder

Our own blood is still the best thing to have in our veins

Contact Info

Product

Resources

About