“…It is, therefore, natural to assume that the chemical blood picture of severe chronic nephritis is the result of inadequate urinary secretion. It did not seem correct to us, however, to look upon non-protein nitrogen increase in the blood as conclusive evidence of renal insufficiency in cases of acute glomerular nephritis, and the data from the following cases of subacute and chronic nephritis make us feel that non-protein nitrogen increase in In this respect our findings in children are in agreement with those found in adults by Bulger and Peters and their coworkers (8) and Straub (9). Bulger and Peters, however, frequently found much more base than could be accounted for by the sum of the principal acids determined (Cl' + HCO3' + protein' + HPO4").…”