STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer

Abstract

Background: Despite advances in our understanding on the pathogenesis of gastric cancer (GC), patients face a poor prognosis. To improve clinical outcomes, effective approaches to diagnosis and treatment employing new diagnostic biomarkers are required to achieve early detection and predict recurrence and prognosis. Materials and Methods: Transcriptome analysis was conducted using surgically resected gastric tissues from four patients with metastatic GC. A total of 228 pairs of primary GC tissues and corresponding normal adjacent tissues were subjected to mRNA expression analysis. To validate our findings, we accessed an integrated microarray dataset and RNA sequencing data of GC cell lines. Results: We identified stimulated by retinoic acid 6 (STRA6) as a differentially overexpressed gene, which encodes a transmembrane protein that mediates the cellular uptake of retinol. To investigate how STRA6 contributes to the malignant phenotype of GC cells, we mined public datasets and found the mRNA encoding retinol binding protein 1 (RBP1), which is associated with retinoid metabolism, was co-expressed with STRA6. Furthermore, STRA6 mRNA levels were significantly higher in GC tissues compared to the corresponding noncancerous adjacent tissues of 228 surgically resected gastric tissue samples. Moreover, patients with high levels of STRA6 mRNA experienced significantly shorter disease-free survival and overall survival. Multivariate analysis revealed that high levels of STRA6 served as a significant risk factor. Conclusion: Patients with high levels of STRA6 mRNA experienced significantly worse clinical outcomes, indicating that STRA6 may serve as a diagnostic and prognostic biomarker of GC.

AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer

“…Despite declines in incidence and mortality, GC remains the third leading cause of cancer-related death (1)(2)(3)(4). Unfortunately, patients with GC have a high rate of metastasis specific to the liver and peritoneum, and prognosis is poor in the absence of curative treatment (5)(6)(7). Improved detection and personalized therapies are required to overcome these hurdles.…”

ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling

“…STRA6, a membrane protein, plays a vital role in retinol metabolism and facilitates the transportation of retinol into cells [53]. Recent research has uncovered the involvement of STRA6 in tumor initiation and progression as well as that STRA6 is highly expressed in various tumor cells, such as thyroid cancer [54,55], colorectal cancer [56], lung cancer [57], gastric cancer [20,58], etc., and is associated with prognosis. He et al found that STRA6 can promote the progression of thyroid cancer through the ILK/AKT/mTOR axis [55].…”

Analysis of immunotherapeutic response-related signatures in esophageal squamous-cell carcinoma

“…Specifically, HPSE, ANO1, and SERPINH1 have been shown to be prognostic indicators of ESCC (38)(39)(40)(41). STRA6, IGFL2, USP2 and CASP14 are associated with the prognosis of other cancers, including hepatocellular carcinoma, bladder cancer, gastric cancer and clear cell renal cell carcinoma (42)(43)(44)(45)(46)(47)(48).The overexpression of CFTR suppressed the proliferation and migration/invasion of ESCC cells and was associated with a good patient prognosis (49). SERPINH1 and BCART1 are associated with various immune checkpoint genes in some cancers (41,50,51).…”