Straight border sign of the liver: spectrum of CT appearances and causes.

Itai, Yuji; Murata, Satoru; Kurosaki, Yoshihisa

doi:10.1148/radiographics.15.5.7501852

Cited by 67 publications

(56 citation statements)

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“…It is based on the fact that decreased or absent portal blood supply was detected on CT during arterial portography [23], and that the reduction of portal flow resulted in loss of the volume of hepatocytes with increased fibrosis and segmental atrophy of the liver [24]. However, confluent fibrosis was located most commonly at the boundary between the anterior and medial segments.…”

Section: Discussionmentioning

confidence: 99%

Confluent hepatic fibrosis in liver cirrhosis: possible relation with middle hepatic venous drainage

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Confluent hepatic fibrosis in liver cirrhosis: possible relation with middle hepatic venous drainage

et al. 2013

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“…The second point in the discussion is the relationship between RILD and the emergence of liver metastases. In our patient, the diagnosis of RILD was based on strictly accepted criteria, including a contrast-enhanced CT and MRI that allowed us to follow the evolution of the characteristic liver lesion until its resolution [7][8][9] . Moreover, the dose of radiation was compatible with RILD occurrence, similar to the timing of a RILD occurrence after radiation exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation induced liver disease (RILD), previously referred to as "radiation hepatitis", can affect patients 4 to 8 wk after liver exposure to radiation [7][8][9][10][11][12] . RILD is a venoocclusive disorder caused by a direct radiation-induced injury of the liver endothelium [10][11][12] .…”

Section: Case Reportmentioning

confidence: 99%

“…Most patients recover completely after 3 to 5 mo but a minority will progress to a chronic phase, with hepatic fibrosis and liver failure; rare cases of fulminant liver failure have been described [10,12] . The diagnosis essentially emerges from the findings of the typical imaging features on contrast-enhanced computed tomography (CT) and/or magnetic resonance imaging (MRI), affecting the liver in the irradiated field: "straight-border" sign [8] , demarcated areas of hypo or hyper attenuation in a non anatomical distribution (contrasting with vascular lesions) [8] , and alteration of the contrast uptake on CT [13] . We describe a case AFP producing liver metastatic gastric cancer in a patient affected by RILD and the implications in terms of diagnostic challenges and pathogenesis.…”

Section: Case Reportmentioning

confidence: 99%

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An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease

Cardinale

Filippis

Corsi

et al. 2013

WJH

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We report a case of an isolated hepatic neoplasia which originated in a site of the liver previously affected by radiation induced liver disease (RILD) in a patient resected for gastric cancer and referred to us for high serum alpha-fetoprotein (AFP) levels. This case challenged us in distiguishing, even histologically, between primary liver cancer and AFP producing gastric cancer metastasis. Only a panel of immunohistochemical markers allowed the definitive diagnosis of liver metastasis of endodermal stem cell-derived and AFP producing gastric cancer. We discuss the criteria for a differential diagnosis, as well as the possible link between RILD and emergence of liver neoplasia.

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“…RILD presents as demarcated areas of hypo-or hyperattenuation in a non-anatomic distribution, contrasting with vascular lesions. 11 No established therapies for classic RILD exist. Treatment of RILD is primarily supportive with a majority succumbing to liver failure.…”

Section: Radiation Tolerance Of Livermentioning

confidence: 99%

Role of External Beam Radiation Therapy in Management of Hepatocellular Carcinoma

Sharma

2014

Journal of Clinical and Experimental Hepatology

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Diagnosis at advanced disease stage and early vascular invasion are the bane of majority of patients with hepatocellular carcinoma (HCC) in India. The currently standardized curative and palliative treatment modalities [surgery, ablative techniques, trans-catheter chemotherapy, systemic chemotherapy] are suboptimal for a significant proportion of disease stages. Interest in radiotherapy for hepatocellular carcinoma has seen a resurgence with revolutionary improvements in targeting radiation doses safely. Encouraging results have been reported with a host of radiation techniques from conformal radiotherapy, stereotactic whole body radiation therapy to charged particle based therapies. The dissemination of this knowledge has been slow across other specialties involved in care of patients with HCC. However the increasing availability of radiotherapy services predicts a hopeful future for wider evaluation of radiotherapy in HCC. ( J CLIN EXP HEPATOL 2014;4:S122-S125)

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Straight border sign of the liver: spectrum of CT appearances and causes.

Cited by 67 publications

References 0 publications

Confluent hepatic fibrosis in liver cirrhosis: possible relation with middle hepatic venous drainage

Confluent hepatic fibrosis in liver cirrhosis: possible relation with middle hepatic venous drainage

An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease

Role of External Beam Radiation Therapy in Management of Hepatocellular Carcinoma

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