Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains

Maassen, C.B.M.; Holten-Neelen, Conny van; Balk, F.R.M.; Bak-Glashouwer, M.J. Heijne Den; Leer, R.J.; Laman, Jon D.; Boersma, W.J.A.; Claassen, Eric

doi:10.1016/s0264-410x(99)00378-3

Cited by 301 publications

(250 citation statements)

References 43 publications

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“…Indeed we, and others, showed that probiotics present distinct strainspecific immunomodulatory capacities in vitro (Hessle et al, 1999;Maassen et al, 2000;Mercenier et al, 2004) which can be closely correlated with their in vivo anti-inflammatory potential. Interestingly, the anti-inflammatory effects of lactobacilli observed after either oral or systemic administration (Foligne et al, 2005;Sheil et al, 2004), suggest that the protective mechanisms might involve regulatory-cell populations.…”

Section: Iii2b : Functional Food: Conceptsupporting

confidence: 53%

Genes involved in obesity: Adipocytes, brain and microflora

et al. 2006

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Obesity and obesity-related disorders such as cardiovascular diseases and metabolic abnormalities including hypertension, hyperinsulinemia, insulin-resistance and type 2 diabetes, are among the most pressing problems in the industrialized world (Friedman, 2003;Kannel et al., 1991 (Reitman et al., 2000), demonstrating that normal adipose tissue development and function is critical for metabolic homeostasis.Obesity results from complex interactions between genes and environmental factors such as diet, food components and/or way of life, and can be viewed as an energy storage disorder in which weight gain results from an energy imbalance (i.e. energy input exceeding output), with most of the excess calories stored as triglycerides in adipose tissue (Smith et al., 2006). Therefore a great deal of attention has focused on the mechanisms controlling food intake and adipose mass, and is of considerable importance for public health and clinical medicine.In this review, we prevalently highlight the complex relationships existing between the white adipose tissue, the central nervous system, the endogenous microbiota, and nutrition. Throughout, we emphasize the most recent findings in the field and consider how it shapes the past knowledge and forecasts the future of research on metabolic disorders, such as obesity.

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Section: Iii2b : Functional Food: Conceptsupporting

confidence: 53%

Genes involved in obesity: Adipocytes, brain and microflora

et al. 2006

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“…Moreover, different Lactobacillus-spQCiQS have a specific effect on the production of cytokins by intestinal leukocytes (Maassen et al, 2000). The stimulation of phagocytic activity of peripheral blood leukocytes and peritoneal macrophages has also been reported for a yeast preparation (Rod riguez et al, 2000).…”

Section: Influence On the Immune Systemmentioning

confidence: 85%

Probiotic feed additives - effectiveness and expected modes of action

Simon¹,

Jadamus²,

Vahjen³

2001

J. Anim. Feed Sci.

128

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In animal nutrition, probiotics are viable microorganisms used as a feed supplement, which lead to beneficial effects for the host animal. For most species a trend towards improved performance has been reported due to the use of probiotics, but statistically significant improvements of weight gain and of feed conversion are rare, mainly because of variations in the individual reactions of the ani mals. However, reductions of the incidence of diarrhoea were significant in most studies with piglets and calves. In contrast to human nutrition, where Lactobacillus species are common probiotic pro ducts, in animal nutrition Enterococcus spp., Saccharomyces yeast, and spore-forming Bacillus spp. are most frequently used as probiotic microorganisms. Furthermore, in human nutrition long-term effects for lasting health promotion and longevity are sought, but the aims of probiotic supplementa tion in modern animal production are fast effects such as improvement of weight gain and feed conversion. Thus, results from probiotic research in the field of human nutrition are not completely valid for animal nutrition.Although 19 probiotic preparations have received temporary approval in the European Union, their modes of action, which lead to beneficial effects, are only partly known. It is very probable that the impact of probiotics on pathogenic and nonpathogenic intestinal bacteria is of prime importance. However, modifications of microstructures and barrier functions of intestinal tissues as well as reac tions of the immune system seem to be involved in the overall effect, directly or as a consequence of modified bacterial populations. In order to specifically improve probiotics and their application in defined indications, more research is needed to determine their underlying mechanisms.

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“…Initially, the immunomodulating capacity of LAB was only referred to the induction of antibody production or the cellular response. Actually, considering the important role played by biological messengers as cytokines in the balance of the immune response, a lot of research work has been done to demonstrate the influence of LAB in the cytokine release signalling pathways for the production of cytokines (Agarwal et al, 1995;Miettinen et al, 1996Miettinen et al, , 2000Maassen et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Interaction of lactic acid bacteria with the gut immune system

et al. 2002

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Health claims of lactic acid bacteria (LAB) used in functional foods and pharmaceutical preparations are based on the capacity of these microorganisms to stimulate the host immune system. In this study, the antigenic effect of LAB (Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus) on the gut immune system of BALB=c mice was evaluated. A dose-dependent increase of the Bcl2 protein was observed with all LAB assayed. Furthermore, the analysis of cytokine-producing cells in the lamina propria of gut showed that TNFa and INFg values, determined in macrophages cultured from Peyer patches, were enhanced for all the LAB assayed. An important increase of interleukins IL-10 and IL-4 was observed mainly in mice fed with Lactobacillus delbrueckii ssp. bulgaricus or Lactobacillus casei, while a significant induction of IL-2 and IL-12 was only observed with L. acidophilus (P < 0.01). These effects were dose dependent. The role of produced cytokines in the balance Th1=Th2 was determined by a systemic antibody response against parenterally injected ovoalbumin. L. casei, L. delbrueckii ssp. bulgaricus and L. acidophilus enhanced the IgG1 response favouring Th2 balance, while L. acidophilus also increased the IgG2a response inducing Th1 balance. S. thermophilus did not influence the balance Th1=Th2. Our studies showed that lactic acid bacteria induce distinct mucosal cytokine profiles showing different adjuvant capacity among them. Thus, selection of probiotic strain with immunological properties must be well defined to influence cytokine expression that favour the claimed immune response.

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Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains

Cited by 301 publications

References 43 publications

Genes involved in obesity: Adipocytes, brain and microflora

Genes involved in obesity: Adipocytes, brain and microflora

Probiotic feed additives - effectiveness and expected modes of action

Interaction of lactic acid bacteria with the gut immune system

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