1990
DOI: 10.1016/0091-3057(90)90223-5
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Strain differences in adrenalectomy-induced alterations in nicotine sensitivity in the mouse

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Cited by 28 publications
(10 citation statements)
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“…For example, apomorphine blocked the prepulse inhibition of the ASR without affecting startle amplitude in male Wistar rats while apomorphine had no effect on prepulse inhibition but in creased startle amplitude in SD rats [18]. In mice, adre nalectomy differentially increased the magnitude of the ASR in response to nicotine in a strain-dependent man ner [19], These differences in startle response to CNS-active drugs further support the central mediation of straindependent differences in startle response. However, the increased response in adrenalectomized mice suggests that this mediation may be a result of adrenal feedback mechanisms.…”
Section: Discussionmentioning
confidence: 80%
“…For example, apomorphine blocked the prepulse inhibition of the ASR without affecting startle amplitude in male Wistar rats while apomorphine had no effect on prepulse inhibition but in creased startle amplitude in SD rats [18]. In mice, adre nalectomy differentially increased the magnitude of the ASR in response to nicotine in a strain-dependent man ner [19], These differences in startle response to CNS-active drugs further support the central mediation of straindependent differences in startle response. However, the increased response in adrenalectomized mice suggests that this mediation may be a result of adrenal feedback mechanisms.…”
Section: Discussionmentioning
confidence: 80%
“…This explanation however appears unlikely, since a marked ADX-induced depressant effect was also observed when data was expressed as percentage of saline activities. Therefore, as reported in mice (Pauly et al 1990a), it appears that modification of glucorticoid levels can alter sensitivity to nicotine. Similar effects of ADX have also been reported with morphine.…”
Section: Discussionmentioning
confidence: 83%
“…This effect of ADX upon locomotor activity and dopamine release suggests that corticosteroids may have multiple roles in mediating these responses. Radioligand binding studies have shown that the increased behavioural sensitivity to nicotine in corticosterone-depleted subjects is due to the absence of corticosteroid exerting an 'antagonistlike' effect on the nicotine receptor (Pauly et al 1990a). However, this inhibition is restricted to receptor binding sites labelled by [ 125 I]--bungarotoxin and not by [ 3 H]-nicotine.…”
Section: Discussionmentioning
confidence: 98%
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