The influence of temperature on the shear performance of asphalt mixtures and the feasibility of using the deformation strength as an index of the high-temperature shear performance of these mixtures were explored in this study. Taking AC-13C and AC-20C asphalt mixtures as the research objects, uniaxial compression, rutting, deformation strength, and uniaxial static load creep tests were carried out at temperatures 40°C, 45°C, 50°C, 55°C, and 60°C. The correlations between the deformation strength and modulus of resilience, compressive strength, dynamic stability, and stiffness of the asphalt mixtures were studied. The test results show that the influence of temperature on the compressive strength, resilience modulus, and deformation strength of the asphalt mixtures decreases significantly as the temperature increased, and the rutting deformation of the two kinds of asphalt mixtures increased as the temperature increased. Strong correlations exist between the deformation strength and the modulus of resilience, the compressive strength, and the dynamic stability of asphalt mixtures, so the deformation strength can be used as an evaluation index of the high-temperature shear performance of asphalt mixtures.