Strain-specific effects of probiotic Lactobacilli on mRNA expression of epigenetic modifiers in intestinal epithelial cells

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

“…These regions include the hippocampus, amygdala, prefrontal cortex, and hypothalamus. This ultimately contributes to improved neurogenesis and neuroplasticity within these brain regions that otherwise have a pathophysiologic association with depressive disorder [ 27 , 82 , 141 , 162 , 163 , 164 ].…”

“…However, no studies have exclusively explored and demonstrated the epigenetic potential of probiotics in depression, considering the recentness of the epigenetic branch of genetic studies. Nevertheless, the existing studies provide some solid footing for understanding the possible epigenetic basis of probiotics in depression [ 2 , 164 , 173 , 176 , 177 , 178 ]. Epigenetic mechanisms introduce long-lasting, heritable, yet reversible phenotypic changes without involving genotypic alteration through methylation of deoxyribonucleic acid (DNA), histone modification, and non-coding ribonucleic acid (RNA) [ 2 , 175 , 176 , 177 , 178 , 179 , 180 , 181 ].…”

“…Gut-modulating agents such as probiotics act as epi-drivers to exert beneficial modulatory epigenetic effects on the host epigenome [ 175 , 181 , 183 , 184 ]. Probiotics exert prophylactic and nullifying epigenetic effects to counter the adverse alteration of the host’s epigenetic signatures [ 164 , 184 ]. A recent study demonstrated the strain-specific epigenetic potential of lactobacilli probiotics, Limosilactobacillus fermentum MTCC 5898 and Lacticaseibacillus rhamnosus MTCC 5897, on DNA and histone modifiers independently and following a challenge test using an inflammation-stimulating, opportunistic pathogenic commensal, Escherichia coli ATCC 14849 [ 164 ].…”

“…The mRNA expression was even higher following a 12-h challenge test with E. coli after a 12-h pre-treatment with Limosilactobacillus fermentum , implying the epigenetic signatures of this probiotic strain. However, no similar effects were exerted by Lacticaseibacillus rhamnosus [ 164 ]. In another study, the same lactobacilli probiotic strains were shown to significantly reduce histone 3 and histone 4 acetylation at 6-h incubation independently and in combination when E. coli were excluded, competed with, or displaced by these probiotic strains.…”

Dietary supplementation with Lacticaseibacillus rhamnosus IDCC3201 alleviates sarcopenia by modulating the gut microbiota and metabolites in dexamethasone-induced models

“…2,7 Probiotics are live microbiota that provide health benefits to the host by maintaining the homeostasis of the intestinal microbiota and the immune system and possessing antiinflammatory and anti-aging properties in human and animal. [8][9][10][11][12][13][14][15][16][17][18] Recent studies have shown that Lacticaseibacillus rhamnosus species are probiotics, a type of intestinal bacteria, and have been reported to provide various biological activi-ties: 19 anti-inflammatory, 20 anti-obesity, 21 immune modulation, 22 gut health (IBD and IBS), [23][24][25] and cholesterol level reduction. In addition, the Lacticaseibacillus rhamnosus IDCC3201 strain used in our study was isolated from infant feces, and it has been confirmed to be 18 anti-allergic, 26 antiinflammatory, anti-pathogenic, 19 and immunomodulatory.…”