At the end of December 2019, a virus, currently known as the novel coronavirus-2019 or 2019 novel coronavirus (2019-nCoV), has emerged with a relatively fast spread rate. Each individual is obliged to participate in the process of preventing the disease from spreading. Additionally, any elements of society should have positive contributions in preventing the spread of this disease, including the non-formal religious education. In this study, the role of Ta'lim andragogy, a non-formal teaching-learning process for adults adopted teacher centered learning, in preventing the spread of coronavirus is investigated. Thus, the focus of this research is to exercise how the concept of ta'lim andragogy based on Science and Al-Quran Literacy can be implemented in strengthening awareness on covid-19. This study uses a qualitative approach with data collection methods through literature review. The data used in this research were mainly originated from text, both in the form of manuscript text (books, magazines, journals, newspapers, etc.) or digital text. Theoretically, ta'lim has a potential as an alternative method in increasing this covid-19 awareness. For this reason, andragogy ta'lim must be modified in such a way, such as by integration with the values coming from the Qur'an, hence creating a new model of ta'lim based on Qur'anic literacy and scientific literacy.