Strategically Designing a Pumpless Microfluidic Device on an “Inert” Polypropylene Substrate with Potential Application in Biosensing and Diagnostics

Shirani, Elham; Razmjou, Amir; Tavassoli, Hossein; Landarani‐Isfahani, Amir; Rezaei, Saghar; Kajani, Abolghasem Abbasi; Asadnia, Mohsen; Hou, Jingwei; Warkiani, Majid Ebrahimi

doi:10.1021/acs.langmuir.7b00537

Cited by 31 publications

(19 citation statements)

References 74 publications

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“…This eliminates the need to use external equipment for pumping mechanism which simplifies the setup and reduces the cost of the device. The “pumpless transportation” mechanism utilizing hydrophilic patterning on hydrophobic substrates was demonstrated in our previous work …”

Section: Introductionmentioning

confidence: 99%

“…The "pumpless transportation" mechanism utilizing hydrophilic patterning on hydrophobic substrates was demonstrated in our previous work. 29 The PP polymer is intrinsically hydrophobic because of the presence of −CH− and −CH 2 − backbone and −CH 3 pendant group and can be used directly as a hydrophobic support from manufacturers to enable pumpless transportation. It is also suitable to be used as a paper-based biosensor, as it is an inexpensive, low density flexible material.…”

Section: Introductionmentioning

confidence: 99%

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Metal–Organic-Framework-Based Enzymatic Microfluidic Biosensor via Surface Patterning and Biomineralization

Mohammad

Razmjou

Liang

et al. 2018

ACS Appl. Mater. Interfaces

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121

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Recently, the biomineralization of enzyme in metal−organic-framework (enzyme-MOF) composite have shown a great potential to increase enzymes stability without compromising their activity; hence, it is desirable for its applications in biosensing devices. Nonetheless, most of the enzyme-MOF research has been focusing on enzyme encapsulation in particle form, which limits its synthesis flexibility for practical applications because of its requirement for postsynthesis immobilization onto solid support. Therefore, to develop a diagnostic device out of the biomineralized enzyme, surface patterning and integration of microfluidic system offers many advantages. In this work, musselinspired polydopamine/polyethyleneimine (PDA/PEI) coating is employed to pattern enzyme-MOF in microfluidic channels and exploit the wettability gradient for "pumpless transportation" effect. As a proof of concept, we combine a cascade reaction of glucose oxidase (GOx) and horseradish peroxidase (HRP) enzymes to detect glucose into a patterned zeolitic imidazole framework-8 (ZIF-8) thin film on a flexible polymeric substrate. The results show that the ZIF-8/GOx&HRP in situ composites on PDA/PEI patterns have good acid and thermal stability compared with samples without ZIF-8. ZIF-8/GOx&HRP in situ shows high selectivity toward glucose, linear sensitivity of 0.00303 Abs/μM, and the limit of detection of 8 μM glucose concentration. An unexpected benefit of this approach is the ability of the ZIF-8 thin-film structure to provide a diffusion limiting effect for substrate influx, thus, producing high range of linear response range (8 μM to 5 mM of glucose). This work provides insights into the spatial location of the enzymes in MOF thin films and the potential of such patterning techniques for MOF-based biosensors using other types of biological elements such as antibodies and aptamers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal–Organic-Framework-Based Enzymatic Microfluidic Biosensor via Surface Patterning and Biomineralization

Mohammad

Razmjou

Liang

et al. 2018

ACS Appl. Mater. Interfaces

Self Cite

121

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“…Recent advancements in nanomaterials and nano technologies have provided us with the possibility of devel oping innovative sensing and biosensing systems that meet the requirements of lowcost and easytouse devices. [247][248][249][250][251] In the last ten years, nanopores/nanochannels have appeared as materials enjoying powerful analytic capacity for sensing and biosensing applications. The latest and the most distinc tive methods devised using nanochannels for sensing and biosensing applications are based on utilizing them as modi fiers for common electrotransducer surfaces, which measure the electrochemical response changes within an electroactive species in the solution thanks to existing analyte within the channels.…”

Section: Application Of Ion-based Nanochannels In Sensing and Biosensing Assaysmentioning

confidence: 99%

Ion Selective Nanochannels: From Critical Principles to Sensing and Biosensing Applications

Soozanipour

Sohrabi

Abazar

et al. 2021

Adv Materials Technologies

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High throughput; (D) Mold and releasing issue, hard to form deep channels Large scale channel array, 2D channel, 1D nanoslit Thin film deposition 30-200 Polysilicon, Silicon dioxide, Silicon nitride, polymer (A) simple process, low cost, fast; (D) Hard to form uniform channels large scale array, 2D channel, 1D nanoslit Hot embossing >50 PET, PC, PS, PMMA, etc. (A) Simple process, low cost; (D) Easy to deformation Large scale array, 2D channel, 1D nanoslit deformation of PDMS 100-800 PDMS (A) Simple process, low cost; (D) Low yield large scale array, V-shaped channel, 2D channel Stress release 20-800 PS, PDMS, Photoresist (A) Low cost, maskless, simple process; (D) Low resolution, Low yield large scale array, V-shaped channel, 1D nanoslit Molecular self-assembly 20-800 Ti, Silicon, Polymer, etc. (A) Low cost; (D) Complex process, Low yield 2D channel, 1D nanoslit

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“…Biosensors are a progress in analytical science, in which their design is based on selective identification of the analysis depending on the physiological components and interactions with physical and chemical detectors. − There are many kinds of biosensors for the recognition of biochemical interactions, such as electrical, optical, calorimetric, etc . Conventional diagnostic methods in medicine require the use of expensive devices that need costly maintenance to ensure an accurate operation .…”

Section: Introductionmentioning

confidence: 99%

High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition

Nankali

Einalou

Asadnia

et al. 2021

ACS Appl. Bio Mater.

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Optical biosensors are sensitive devices used in bioanalytics detection. Analysis of blood constituents is very important for the detection of major diseases and also performs a significant role in the diagnosis of diabetes, various cancers, and cardiovascular disorders. In this work, a three-dimensional photonic crystal-based biosensor composed of zeolitic imidazolate framework-8 (ZIF-8) nanoarrays are placed on polydopamine (PDA) coated on a silicon substrate. This sensor is designed, simulated, and evaluated for various blood components in the wavelength range of 1.1 to 1.5 μm by the finite-difference time-domain (FDTD) method. The proposed biosensor was used for 10 types of blood components such as biotin−streptavidin, bovine serum albumin (BSA), cytop, glucose (40 mg/100 mL), hemoglobin, blood plasma, Sylgard184, white blood compounds, urethane dimethacrylate, and polyacrylamide. The FDTD technique was used for the performance analysis of the biosensor. The design parameters of the radius, the lattice constant, the thickness of the ZIF-8 arrays, and the PDA layer thickness are chosen to optimize the photonic crystal structure. This study indicates that the thickness of the PDA is the most important parameter for peak wavelength value in comparison to the other physical parameters. The factors for optimizing the photonic crystal-based biosensors such as the peak wavelength value (PWV), sensitivity, full width at half-maximum (FWHM), and figure of merit (FOM) are significant in comparison with pertinent works in this field, which evaluated 171 nm/RIU, 7.62 nm, and 22.5 RIU −1 , respectively. A change of 0.01 nm in the refractive index of the constituents of the blood leads to a shift of 80 nm in the maximum peak wavelength, therefore acting as a functional biosensor with a high detection limit of 0.004 RIU.

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Strategically Designing a Pumpless Microfluidic Device on an “Inert” Polypropylene Substrate with Potential Application in Biosensing and Diagnostics

Cited by 31 publications

References 74 publications

Metal–Organic-Framework-Based Enzymatic Microfluidic Biosensor via Surface Patterning and Biomineralization

Metal–Organic-Framework-Based Enzymatic Microfluidic Biosensor via Surface Patterning and Biomineralization

Ion Selective Nanochannels: From Critical Principles to Sensing and Biosensing Applications

High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition

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