Strategies and knowledge gaps for improving nanomaterial biocompatibility

Hu, Xiangang; Sun, Anqi; Kang, Weilu; Zhou, Qixing

doi:10.1016/j.envint.2017.03.001

Cited by 37 publications

(14 citation statements)

References 129 publications

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“…Owing to its unique physical properties, nanoparticles (NPs) are able to transfer through loose vasculature and infiltrate into inflamed area as well as the tumor site 23 . Over the years, different versions of nanotechnology have been generated based on the specific demand, from primitive nanomaterials to various modified transformation 24,25 . Among these, magnetic nanoparticles (MNPs) are a class of nanomaterials widely used as drug delivery, imaging, diagnosis, and targeting due to the ultra‐small nanometer size, inherent magnetic resonance imaging (MRI) characteristics, superior biocompatibility, flexible surface chemistry, and lack of systemic toxicities.…”

Section: Introductionmentioning

confidence: 99%

“…23 Over the years, different versions of nanotechnology have been generated based on the specific demand, from primitive nanomaterials to various modified transformation. 24,25 Among these, magnetic nanoparticles (MNPs) are a class of nanomaterials widely used as drug delivery, imaging, diagnosis, and targeting due to the ultra-small nanometer size, inherent magnetic resonance imaging (MRI) characteristics, superior biocompatibility, flexible surface chemistry, and lack of systemic toxicities. These have prompted scientists to try to apply MNPs in various diseases, the earliest trials in treatment of tumors, more recently in therapy of inflammatory diseases including rheumatoid arthritis.…”

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confidence: 99%

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Magnetic nanoparticles: A new diagnostic and treatment platform for rheumatoid arthritis

Liu

Cao

Sun

et al. 2020

Journal of Leukocyte Biology

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Rheumatoid arthritis (RA) is a chronic inflammatory condition characterized by articular synovitis that eventually leads to the destruction of cartilage and bone in the joints with resulting pain and disability. The current therapies for RA are divided into 4 categories: non-steroidal antiinflammatory drugs (NSAIDs), glucocorticoids, nonbiological disease-modifying anti-rheumatic drugs (DMARDs), and biological DMARDs. Each drug grouping is beset with significant setbacks that not only include limited drug bioavailability and high clearance, but also varying degrees of drug toxicity to normal tissues. Recently, nanotechnology has provided a promising tool for the development of novel therapeutic and diagnostic systems in the area of malignant and inflammatory diseases. Among these, magnetic nanoparticles (MNPs) have provided an attractive carrier option for delivery of therapeutic agents. Armed with an extra magnetic probe, MNPs are capable of more accurately targeting the local lesion with avoidance of unpleasant systemic side effects. This review aims to provide an introduction to the applications of magnetic nanoparticles in RA, focusing on the latest advances, challenges, and opportunities for future development. K E Y W O R D S magnetic nanoparticles, rheumatoid arthritis 1 INTRODUCTION Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition accompanied by progressive joint destruction. 1-3 Although the precise pathogenesis of RA remains unclear, a multi-factor congeries of influences that include environment, infections, and abnormal gene

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Magnetic nanoparticles: A new diagnostic and treatment platform for rheumatoid arthritis

Liu

Cao

Sun

et al. 2020

Journal of Leukocyte Biology

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“…Such a challenge is due to very little data on prevalence of biogenic ENM as a prospective, commercially available agricultural product [29,30]. Several risk assessment approaches have been used to simulate and calculate predicted environmental concentrations (PECs) of chemically synthesized ENMs but there is an unfilled gap about the biogenic ENMs [31][32][33].…”

Section: Enms Dispersal In Abiotic and Biotic Environmentmentioning

confidence: 99%

Understanding the safety aspect of biologically synthesized agriculturally useful nanomaterials for humans and environment

Priyam¹,

Singh²

2018

Front Nanosci Nanotech

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“…However, the health risks and adverse effects (e.g., nanotoxicity in vivo and in vitro) of nanomaterials caused by their high specific surface area and physiochemical activity are also attracting increasing attention 8, 9, 10, 11. Many methods have been proposed to reduce nanotoxicity, such as surface modification and the regulation of shapes, sizes, charges, defects, and crystal faces 12, 13, 14, 15. Unfortunately, the resulting improvements in the biocompatibility of nanomaterials were in most cases accompanied by reduced functionality.…”

Section: Introductionmentioning

confidence: 99%

Screening Small Metabolites from Cells as Multifunctional Coatings Simultaneously Improves Nanomaterial Biocompatibility and Functionality

Sun

Ban

2018

Advanced Science

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Currently, nanomaterials face a dilemma due to their advantageous properties and potential risks to human health. Here, a strategy to improve both nanomaterial biocompatibility and functionality is established by screening small metabolites from cells as nanomaterial coatings. A metabolomics analysis of cells exposed to nanosilver (nAg) integrates volcano plots (t‐tests and fold change analysis), partial least squares‐discriminant analysis (PLS‐DA), and significance analysis of microarrays (SAM) and identifies six metabolites (l‐aspartic acid, l‐malic acid, myoinositol, d‐sorbitol, citric acid, and l‐cysteine). The further analysis of cell viability, oxidative stress, and cell apoptosis reveals that d‐sorbitol markedly reduces nAg cytotoxicity. Subsequently, small molecule loading, surface oxidation, and ionic release experiments support d‐sorbitol as the optimal coating for nAg. Importantly, d‐sorbitol loading improves the duration of the antibacterial activity of nAg against Escherichia coli and Staphylococcus aureus. The biocidal persistence of nAg‐sorbitol is extended beyond 9 h, and the biocidal effects at 12 h are significantly higher than those of naked nAg. This work proposes a new strategy to improve the biocompatibility and functionality of nAg simultaneously by screening small metabolites from cells as nanomaterial functional coatings, a method that can be applied to mitigate the side effects of other nanomaterials.

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Strategies and knowledge gaps for improving nanomaterial biocompatibility

Cited by 37 publications

References 129 publications

Magnetic nanoparticles: A new diagnostic and treatment platform for rheumatoid arthritis

Magnetic nanoparticles: A new diagnostic and treatment platform for rheumatoid arthritis

Understanding the safety aspect of biologically synthesized agriculturally useful nanomaterials for humans and environment

Screening Small Metabolites from Cells as Multifunctional Coatings Simultaneously Improves Nanomaterial Biocompatibility and Functionality

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