Strategies for Liposome Drug Delivery Systems to Improve Tumor Treatment Efficacy

Abstract

In the advancement of tumor therapy, in addition to the search for new antitumor compounds, the development of nano-drug delivery systems has opened up new pathways for tumor treatment by addressing some of the limitations of traditional drugs. Liposomes have received much attention for their high biocompatibility, low toxicity, high inclusivity, and improved drug bioavailability. They are one of the most studied nanocarriers, changing the size and surface characteristics of liposomes to better fit the tumor environment by taking advantage of the unique pathophysiology of tumors. They can also be designed as tumor targeting drug delivery vehicles for the precise delivery of active drugs into tumor cells. This paper reviews the current development of liposome formulations, summarizes the characterization methods of liposomes, and proposes strategies to improve the effectiveness of tumor treatment. Finally, it provides an outlook on the challenges and future directions of the field.

Recent Advances in CXCL12/CXCR4 Antagonists and Nano-Based Drug Delivery Systems for Cancer Therapy

“…Nano-based drug delivery systems (NDDS) have attracted significant concerns with regard to their potential application in cancer therapy over the last few decades [ 119 ]. For conventional chemotherapeutic drugs, the most significant drawbacks of NDDS relate to unsatisfactory therapeutic effects and serious adverse drug reactions; these are closely associated with poor stability, multi-drug resistance, and uncontrolled systemic distribution [ 120 ].…”

Nanocarrier system: An emerging strategy for bioactive peptide delivery

“…Liposomal drug formulation could only be affirmative if the encapsulation efficiency is such that therapeutic doses could be delivered in a reasonable amount of lipid, since lipids in high doses may be toxic and also cause non-linear (saturable) pharmacokinetics. Liposomes may deliver the drug to the cells selectively, but the pharmacological activity depends on the ability of the intact drug against degradation to diffuse into the cytoplasm from the endosomes in sufficient amounts ( 33 , 34 ).…”

Advances in Nanoliposomes for the Diagnosis and Treatment of Liver Cancer

“…10 Second-generation liposomes have been designed as tumor-targeting drug delivery vehicles for the precise delivery of active drugs into tumor cells. 11 The unique properties of liposomes, including their biocompatibility, biodegradability, amphiphilic nature, low toxicity, non-ionicity, sustained release, and ability to be actively targeted, have provided many biomedical opportunities, especially for drug delivery. 12 Liposomes can encapsulate drugs to prevent degradation by the immune system, and are highly biocompatible and effectively targeted.…”