2021
DOI: 10.3390/polym13040624
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Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

Abstract: Synthetic polypeptides and polymer-peptide hybrid materials have been successfully implemented in an array of biomedical applications owing to their biocompatibility, biodegradability and ability to mimic natural proteins. In addition, these materials have the capacity to form complex supramolecular structures, facilitate specific biological interactions, and incorporate a diverse selection of functional groups that can be used as the basis for further synthetic modification. Like conventional synthetic polyme… Show more

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Cited by 35 publications
(32 citation statements)
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“…In addition, if the bonding structure or the linker between a single cell and a bead is replaced with a cleavable structure, it is possible to remove the magnetic bead on clustered cells to eliminate its influence on cell itself. [38][39][40] Therefore, the proposed device enables selective separation and quantitative clustering using programmable designs, which provide an efficient lab-on-achip platform for intercellular interaction analysis, and it will be possible to use in various biomedical applications such as the identification of interactions between cells, drug reactivity, and cell engineering using a combination of cells implemented in the optimal environment.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, if the bonding structure or the linker between a single cell and a bead is replaced with a cleavable structure, it is possible to remove the magnetic bead on clustered cells to eliminate its influence on cell itself. [38][39][40] Therefore, the proposed device enables selective separation and quantitative clustering using programmable designs, which provide an efficient lab-on-achip platform for intercellular interaction analysis, and it will be possible to use in various biomedical applications such as the identification of interactions between cells, drug reactivity, and cell engineering using a combination of cells implemented in the optimal environment.…”
Section: Discussionmentioning
confidence: 99%
“…Peptides can increase their accumulation in specific tissues by adding targeting groups, adding transmembrane peptides to improve membrane penetration efficiency and endosome escape efficiency, adding self-assembly modules to increase drug stability, increasing response groups, and promoting drug release at the targeted location ( Newman and Benoit, 2018) . Stimulus-responsive groups can be roughly classified into enzyme-responsive ( He et al, 2016 ), pH-responsive ( Dharmayanti et al, 2021 ), and redox-responsive. By taking advantage of biotransformations, nucleic acids which were modified with specific groups were capable of transferring to bioactive nucleic acids in living cells.…”
Section: Application Of Biomimetic Exosomesmentioning
confidence: 99%
“…Synthetic polymer‐peptide materials have exhibited great potential in biomedical applications due to their biocompatibility, biodegradability and ability to mimic natural proteins. In addition, these materials can form complex supramolecular structures to facilitate specific biological interactions and combine a variety of selected functional groups to serve as the basis for further synthetic modifications [108–109] . While PEPylation (protein‐polypeptide conjugation) was infrequently developed previously, with only a few attempts made by random tagging.…”
Section: Post‐polymerization Reactions On Different Side‐chains Of Po...mentioning
confidence: 99%
“…In addition, these materials can form complex supramolecular structures to facilitate specific biological interactions and combine a variety of selected functional groups to serve as the basis for further synthetic modifications. [108][109] While PEPylation (protein-polypeptide conjugation) was infrequently developed previously, with only a few attempts made by random tagging. In the early stage, Walde and co-workers linked poly(l-lysine) to enzymes such as α-chymotrypsin and horseradish peroxidase using the aldehyde-hydrazine reaction (Scheme 14a).…”
Section: Modification Of Other Species Of Side Chainsmentioning
confidence: 99%