Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases

Prata, Cecilia; Maraldi, Tullia; Angeloni, Cristina

doi:10.3390/ijms23126439

Cited by 3 publications

(1 citation statement)

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“…Free radical oxidative damage and abnormal neuronal metabolism are important factors in the development of neurodegenerative diseases [1]. Tea polyphe-*Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Research Progress on the Therapeutic Mechanism of Tea Polyphenols in Neurodegenerative Diseases

Yu,

2023

JBM

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In recent years, the incidence of neurodegenerative diseases, mainly Alzheimer's disease, Parkinson's disease, vascular dementia, and cerebral ischemia, has been rising gradually, which has a serious impact on the physiological state and quality of life of human beings in old age, and the current clinical drugs are unsatisfactory in terms of therapeutic efficacy and healing, which has made this kind of diseases become a social medical problem. Tea polyphenols are the main functional components of tea and have great potential in neuroprotection. In this paper, we review the research on tea polyphenols in neurodegenerative diseases, with the aim of providing a new entry point for the treatment of neurodegenerative diseases.

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“…Free radical oxidative damage and abnormal neuronal metabolism are important factors in the development of neurodegenerative diseases [1]. Tea polyphe-*Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Research Progress on the Therapeutic Mechanism of Tea Polyphenols in Neurodegenerative Diseases

Yu,

2023

JBM

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Comparative proteomics reveal the humoral immune rejection of pearl oyster Pinctada fucata to xenograft from Pinctada maxima

Wang,

Guo,

et al. 2024

Aquaculture

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Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats

Wang,

Deng,

et al. 2024

J Transl Med

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Background Aging is a multifaceted process that affects all organ systems. With the increasing trend of population aging, aging-related diseases have resulted in significant medical challenges and socioeconomic burdens. Mesenchymal stromal cells (MSCs), due to their antioxidative stress, immunoregulatory, and tissue repair capabilities, hold promise as a potential anti-aging intervention. Methods In this study, we transplanted MSCs into naturally aged rats at 24 months, and subsequently examined levels of aging-related factors such as β-galactosidase, superoxide dismutase, p16, p21 and malondialdehyde in multiple organs. Additionally, we assessed various aging-related phenotypes in these aged rats, including immune senescence, lipid deposition, myocardial fibrosis, and tissue damage. We also conducted a 16 S ribosomal ribonucleic acid (rRNA) analysis to study the composition of gut microbiota. Results The results indicated that MSCs significantly reduced the levels of aging-associated and oxidative stress-related factors in multiple organs such as the heart, liver, and lungs of naturally aging rats. Furthermore, they mitigated chronic tissue damage and inflammation caused by aging, reduced levels of liver lipid deposition and myocardial fibrosis, alleviated aging-associated immunodeficiency and immune cell apoptosis, and positively influenced the gut microbiota composition towards a more youthful state. This research underscores the diverse anti-aging effects of MSCs, including oxidative stress reduction, tissue repair, metabolic regulation, and improvement of immune functions, shedding light on the underlying anti-aging mechanisms associated with MSCs. Conclusions The study confirms that MSCs hold great promise as a potential anti-aging approach, offering the possibility of extending lifespan and improving the quality of life in the elderly population.

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Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases

Abstract: The great increase in life expectancy is linked to the necessity of counteracting chronic-degenerative diseases, e [...]

Cited by 3 publications

References 20 publications

Research Progress on the Therapeutic Mechanism of Tea Polyphenols in Neurodegenerative Diseases

Research Progress on the Therapeutic Mechanism of Tea Polyphenols in Neurodegenerative Diseases

Comparative proteomics reveal the humoral immune rejection of pearl oyster Pinctada fucata to xenograft from Pinctada maxima

Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats

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