Strategies to improve the quality of survival for childhood brain tumour survivors

Tallen, Gesche; Resch, Anika; Calaminus, Gabriele; Wiener, Andreas; Leiss, Ulrike; Pletschko, Thomas; Friedrich, Carsten; Langer, Thor﻿s﻿ten; Grabow, Desiree; Driever, Pablo Hernáiz; Kortmann, Rolf Dieter; Timmermann, Beate; Pietsch, Torsten; Warmuth‐Metz, Monika; Bison, Brigitte; Thomale, Ulrich W.; Krauß, Jürgen; Mynarek, Martin; Hoff, Katja von; Ottensmeier, Holger; Frühwald, Michael C.; Kramm, Christof M.; Temming, Petra; Müller, Hermann L.; Witt, Olaf; Kordes, Uwe; Fleischhack, Gudrun; Gnekow, Astrid; Rutkowski, Stefan

doi:10.1016/j.ejpn.2015.07.011

Cited by 41 publications

(21 citation statements)

References 181 publications

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“…Patients suffering from epilepsy should be evaluated using the ENGEL classification for control of frequency and severity of seizures [29,121]. Evaluation of quality of survival measures should include direct measures and patient-reported outcomes [61,81,116]. Extent and frequency of these investigations have to be adapted to the individual patient.…”

Section: Follow-up and Rehabilitationmentioning

confidence: 99%

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

et al. 2019

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Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors of WHO grades I and II occurring throughout all pediatric age groups and at all central nervous system (CNS) sites. The tumors are characterized by a slow growth rate and may show periods of growth arrest. Around 40% of all LGG patients can be cured by complete neurosurgical resection and are followed by close observation. In case of relapse, second resection often is possible. Following incomplete resection observation is recommended, as long as there is no radiologic tumor growth and the patient does not suffer from significant, tumor-related symptoms. This also applies to patients with a diagnosis of LGG on the basis of radiological criteria. By contrast, clinical worsening and / or radiologic progression are an indication to treatment with either chemo- or radiotherapy. Overall survival is around 90%, and many patients survive with residual tumor, i. e. they suffer from chronic disease. All patients need comprehensive neuro-oncological care, the principles and details of which are summarized in the current guidelines. These represent standard of care for diagnostic work-up (including neuroimaging and neuropathology), and for therapeutic decisions (including the indications to non-surgical treatment) as well as concepts for neurosurgical intervention, chemotherapy and radiotherapy as well as surveillance and rehabilitation. The current treatment algorithm was compiled by members of the LGG working group of the SIOP-E brain tumor group (SIOP-E-BTG) and is based upon the results of previous European LGG studies and international reports.

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Section: Follow-up and Rehabilitationmentioning

confidence: 99%

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

et al. 2019

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“…It is expected that the favorable depth-dose curves and linear energy transfer (LET) characteristics of charged particles will allow a precise targeting of deep-seated tumors while reducing the ionizing dose and irradiated volume of normal tissue. It is expected that these attempts to achieve a precise and more target-specific irradiation will help to lower the toxicity rates and the risk of developing secondary tumors [5][6][7][8][9][10][11]. In fact, particles pass through normal tissues on their track without losing much energy but instead releasing the main carried energy at a specific tissue depth shortly before their complete stop.…”

Section: Introductionmentioning

confidence: 99%

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

Szymonowicz

Krysztofiak

Linden

et al. 2020

Cells

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Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues include the increasing use of particle therapy (e.g., proton therapy) worldwide. Yet potential differences in the biology of DNA damage induction and repair between irradiation with X-ray photons and protons remain elusive. We compared the differences in DNA double strand break (DSB) repair and survival of cells compromised in non-homologous end joining (NHEJ), homologous recombination repair (HRR) or both, after irradiation with an equal dose of X-ray photons, entrance plateau (EP) protons, and mid spread-out Bragg peak (SOBP) protons. We used super-resolution microscopy to investigate potential differences in spatial distribution of DNA damage foci upon irradiation. While DNA damage foci were equally distributed throughout the nucleus after X-ray photon irradiation, we observed more clustered DNA damage foci upon proton irradiation. Furthermore, deficiency in essential NHEJ proteins delayed DNA repair kinetics and sensitized cells to both, X-ray photon and proton irradiation, whereas deficiency in HRR proteins sensitized cells only to proton irradiation. We assume that NHEJ is indispensable for processing DNA DSB independent of the irradiation source, whereas the importance of HRR rises with increasing energy of applied irradiation.

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“…Trotz guter subjektiver Lebensqualität ist zudem auch die soziale Integration (Schule und Berufsausbildung, Lebenspartner und Familie) Überlebender oft beeinträchtigt [10]. Zur Erkennung und Vermeidung dieser Einschränkungen in aktuellen und künftigen Therapieoptimierungsstudien sollten Betroffene auch im Adoleszentenund Erwachsenenalter regelmäßig einer strukturierten Nachsorge mit Evaluation wichtiger neurologischer, neuropsychologischer, endokriner und pädiatrisch-internistischer Aspekte zugeführt werden.…”

Section: Spätfolgenunclassified

Hirntumoren des Kindes- und Jugendalters

Rutkowski¹

2018

TumorDiagn u Ther

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Strategies to improve the quality of survival for childhood brain tumour survivors

Cited by 41 publications

References 181 publications

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

Hirntumoren des Kindes- und Jugendalters

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