Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

Tian, Bin; Zhang, Ming; Kang, Xin

doi:10.3389/fbioe.2023.1104214

Cited by 4 publications

(2 citation statements)

References 117 publications

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“…Better clinical outcome was evident in patients undergoing simultaneous meniscal repair and ACL reconstruction than in patients having an isolated meniscal repair. The release of cytokines and growth factors after the drilling of bone tunnels could improve meniscal healing [22, 56]. Pogorelic et al [50] conducted a study on adolescents and analysed the result of outside‐in suturing and all‐inside dart fixation.…”

Section: Discussionmentioning

confidence: 99%

Outside‐in repair technique is effective in traumatic tears of the meniscus in active adults: a systematic review

Migliorini

Pilone

Bell³

et al. 2023

Knee surg. sports traumatol. arthrosc.

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Purpose Meniscal injuries are common. Outside-in meniscal repair is one of the techniques advocated for the management of traumatic meniscal tears. This systematic review investigated the outcomes of the outside-in repair technique for the management of traumatic tears of the menisci. The outcomes of interest were to investigate whether PROMs improved and to evaluate the rate of complications. Methods Following the 2020 PRISMA statement, in May 2023, PubMed, Web of Science, Google Scholar, and Embase were accessed with no time constraints. All the clinical investigations which reported data on meniscal repair using the outside-in technique were considered for inclusion. Only studies which reported data on acute traumatic meniscal tears in adults were considered. Only studies which reported a minimum of 24 months of follow-up were eligible. Results Data from 458 patients were extracted. 34% (155 of 458) were women. 65% (297 of 458) of tears involved the medial meniscus. The mean operative time was 52.9 ± 13.6 min. Patients returned to their normal activities at 4.8 ± 0.8 months. At a mean of 67-month follow-up, all PROMs of interest improved: Tegner scale (P = 0.003), Lysholm score (P < 0.0001), International Knee Documentation Committee (P < 0.0001). 5.9% (27 of 458) of repairs were considered failures. Four of 186 (2.2%) patients experienced a re-injury, and 5 of 458 (1.1%) patients required re-operation. Conclusion Meniscal repair using the outside-in technique can be effectively performed to improve the quality of life and the activity level of patients with acute meniscal tears. Level of evidence Level IV.

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Section: Discussionmentioning

confidence: 99%

Outside‐in repair technique is effective in traumatic tears of the meniscus in active adults: a systematic review

Migliorini

Pilone

Bell³

et al. 2023

Knee surg. sports traumatol. arthrosc.

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“…Tendon-bone healing after tendon insertion reconstruction is mainly indirect healing. That is, the formation of initial fibrous scars between interfaces and then the formation of collagen fibers are gradually organized, thereby forming Sharpey-like collagen fibers, which are related to interface strength; and their number and size have a great influence on the biomechanical effects of grafts [ 7 – 9 ]. A variety of clinical treatment options have been adopted to prevent the healing of tendon-bone injury scars, all of which have a poor therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration

Chen

Jiang

et al. 2023

Med Sci Monit

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Tendon-bone injuries are a prevalent health concern associated with sports and other physically demanding activities. These injuries have a limited innate healing ability, often leading to the formation of scar tissue rather than the regeneration of healthy tendon tissue. This scar tissue results from excessive fibrosis during the early healing process and often leads to reduced tendon function and an increased risk of reinjury. Traditionally, surgical reconstruction has been the primary treatment for tendon-bone injuries. However, restoring the natural structure and mechanical properties of tendons after surgical reconstruction presents a considerable challenge. Recently, the potential of stem cell therapy has been explored as an alternative treatment approach. In particular, a new type of pluripotent stem cell known as tendon stem cells (TDSCs) has been identified within tendon tissue. These cells exhibit the potential for self-renewal and multidirectional differentiation, meaning they can differentiate into fibroblasts and chondrocytes. These differentiated cells can aid in the repair and regeneration of new tissues by producing collagen and other matrix molecules that provide structural support. TDSCs have become a focal point in research for treating tendon-bone injuries and related conditions. The potential use of these cells provides a basis for both basic research and clinical applications, particularly in understanding the tendon-bone healing process and identifying factors that affect the ability of TDSCs to promote this healing. This review article aims to analyze the role of TDSCs in tendon-bone healing, understanding their therapeutic potential and contributing to the development of effective treatment strategies for tendon-bone injuries.

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Effects of Different Electrospinning Methods with i-PRF on the Differentiation of Tendon Stem Cells

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2024

ACM

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Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future

Cited by 4 publications

References 117 publications

Outside‐in repair technique is effective in traumatic tears of the meniscus in active adults: a systematic review

Outside‐in repair technique is effective in traumatic tears of the meniscus in active adults: a systematic review

A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration

Effects of Different Electrospinning Methods with i-PRF on the Differentiation of Tendon Stem Cells

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