Strategies to Reduce Oxidative Stress in Glaucoma Patients

Pinazo-Durán, María Dolores; Shoaie-Nia, Kian; Zanón‐Moreno, Vicente; Sanz-González, Silvia M.; Castillo, Javier; García-Medina, J.J.

doi:10.2174/1570159x15666170705101910

Cited by 61 publications

(46 citation statements)

References 138 publications

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“…Over the past several decades, oxidative stress has been found to be involved in the pathogenesis and development of many diseases, including ophthalmic diseases (Nishimura et al, 2017;Pinazo-Duran et al, 2018), diabetes (Rochette et al, 2018), cardiovascular diseases (Luscher, 2015;Munzel et al, 2015;Schiattarella and Hill, 2017), atherosclerosis (Forstermann et al, 2017), arthritis (Bala et al, 2017;Kardes and Karagulle, 2018), dermatological diseases (Rojo de la Vega et al, 2018), respiratory diseases (Hecker, 2018), hepatic diseases (Lee et al, 2019), urinary system diseases (Andersson, 2018), cancer (Poprac et al, 2017), neurodegenerative disorders (Jiang et al, 2016), and other nervous system diseases (D'Amico et al, 2013;Patel, 2016;Pei and Fan, 2017). Moreover, oxidative stress also participates in pathological processes after ICH (Aronowski and Zhao, 2011).…”

Section: Discussionmentioning

confidence: 99%

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

Tan

et al. 2020

Front. Pharmacol.

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Upregulation of neuronal oxidative stress is involved in the progression of secondary brain injury (SBI) following intracerebral hemorrhage (ICH). In this study, we investigated the potential effects and underlying mechanisms of luteolin on ICH-induced SBI. Autologous blood and oxyhemoglobin (OxyHb) were used to establish in vivo and in vitro models of ICH, respectively. Luteolin treatment effectively alleviated brain edema and ameliorated neurobehavioral dysfunction and memory loss in vivo. Also, in vivo, we found that luteolin promoted the activation of the sequestosome 1 (p62)/kelch-like enoyl-coenzyme A hydratase (ECH)-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by enhancing autophagy and increasing the translocation of Nrf2 to the nucleus. Meanwhile, luteolin inhibited the ubiquitination of Nrf2 and increased the expression levels of downstream antioxidant proteins, such as heme oxygenase-1 (HO-1) and reduced nicotinamide adenine dinucleotide phosphate (NADPH): quinine oxidoreductase 1 (NQO1). This effect of luteolin was also confirmed in vitro, which was reversed by the autophagy inhibitor, chloroquine (CQ). Additionally, we found that luteolin inhibited the production of neuronal mitochondrial superoxides (MitoSOX) and alleviated neuronal mitochondrial injury in vitro, as indicated via tetrachloro-tetraethylbenzimidazol carbocyanine-iodide (JC-1) staining and MitoSOX staining. Taken together, our findings demonstrate that luteolin enhances autophagy and anti-oxidative processes in both in vivo and in vitro models of ICH, and that activation of the p62-Keap1-Nrf2 pathway, is involved in such luteolin-induced neuroprotection. Hence, luteolin may represent a promising candidate for the treatment of ICH-induced SBI.

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Section: Discussionmentioning

confidence: 99%

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

Tan

et al. 2020

Front. Pharmacol.

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“…Considering that oxidative stress is involved in the mechanism of glaucoma development and recent studies suggest the possibility of effects of factors other than IOP [31,32], the effects of lifestyle or nutrient intake may contribute to the development of glaucoma. Calcium plays a role in oxidative stress, and impaired calcium regulation has been implicated in neurodegenerative diseases, including glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

et al. 2020

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To investigate the association between nutrient intake and primary open angle glaucoma (POAG) in Koreans, a population-based, cross-sectional survey, the Korean National Health and Nutrition Examination Survey, was analyzed. Glaucoma diagnosis was based on criteria established by the International Society of Geographic and Epidemiologic Ophthalmology. Multivariate regression analysis was used to assess the correlation between dietary intake and the prevalence of POAG in all enrolled subjects. In the low Body mass index(BMI) group (BMI <18.5), females with POAG had significantly lower intakes of energy, protein, fat, carbohydrate, ash, calcium, phosphorus, sodium, potassium, vitamin A, B-carotene, thiamin, riboflavin, and vitamin C than their non-glaucoma counterparts, based on a multivariate logistic regression analysis (all p < 0.05). In females with a medium BMI (18.5 ≤ BMI < 23), POAG showed a significant association with lower food intake, energy, protein, calcium, phosphorus, potassium, thiamin and niacin. (all p < 0.05). Lower protein thiamine intake in medium BMI males was related to POAG. Low dietary intake of several nutrients showed an association with glaucoma in low BMI female subjects. An insufficient intake of certain nutrients may be associated with an increased risk of glaucoma in Koreans. Further large-scale cohort studies are needed to determine how specific nutrients alter the risk of glaucoma.

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“…CoQ10 is synthesized endogenously, but it can be taken also as exogenous antioxidant [ 62 , 63 ] and is well tolerated over a wide dosage range, with minimal side effects [ 64 ]. Some authors reported that CoQ10 may have a beneficial effect in the treatment of oxidative phosphorylation disorders [ 65 ] and can reduce oxidative stress in glaucoma patients [ 66 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

et al. 2018

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Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation.The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.

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Strategies to Reduce Oxidative Stress in Glaucoma Patients

Cited by 61 publications

References 138 publications

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

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