Strategies towards Orthopaedic Tissue Engineered Graft Generation: Current Scenario and Application

Mallick, Sarada Prasanna; Beyene, Zerihun; Suman, Dheerendra Kumar; Madhual, Abhimanyu; Singh, B. N.; Srivastava, Pradeep

doi:10.1007/s12257-019-0086-6

Cited by 15 publications

(7 citation statements)

References 128 publications

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“… 5 – 7 Other treatment methods, including distraction osteogenesis, growth factor loading, electrical stimulation, Masquelet-induced membrane technique, and various combinations of these methods, have also been developed in recent years. 8 , 9 However, the tedious and arduous treatment period and numerous potential complications limit their clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

et al. 2022

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Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but they can cause a series of complications. To address this problem, researchers have constructed various implantable biomaterials. However, the original pathological microenvironment of bone defects, such as residual tumors, severe infection, or other bone diseases, could further affect bone regeneration. Thus, the rational design of versatile biomaterials with integrated bone therapy and regeneration functions is in great demand. Many strategies have been applied to fabricate smart stimuli-responsive materials for bone therapy and regeneration, with stimuli related to external physical triggers or endogenous disease microenvironments or involving multiple integrated strategies. Typical external physical triggers include light irradiation, electric and magnetic fields, ultrasound, and mechanical stimuli. These stimuli can transform the internal atomic packing arrangements of materials and affect cell fate, thus enhancing bone tissue therapy and regeneration. In addition to the external stimuli-responsive strategy, some specific pathological microenvironments, such as excess reactive oxygen species and mild acidity in tumors, specific pH reduction and enzymes secreted by bacteria in severe infection, and electronegative potential in bone defect sites, could be used as biochemical triggers to activate bone disease therapy and bone regeneration. Herein, we summarize and discuss the rational construction of versatile biomaterials with bone therapeutic and regenerative functions. The specific mechanisms, clinical applications, and existing limitations of the newly designed biomaterials are also clarified.

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Section: Introductionmentioning

confidence: 99%

Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

et al. 2022

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“…Injured cartilage caused by trauma or degenerative disease (e.g., arthritis) has limited intrinsic healing capacity because of the absence of a blood supply. 1,2 For this reason, there have been numerous efforts to develop surgical methods to reconstruct the cartilage tissue. The most widely used clinical procedures for cartilage repair include autografts, autologous chondrocyte transplantation, and microfracture, which penetrate the wound until the subchondral bone for recruiting blood flow.…”

Section: Introductionmentioning

confidence: 99%

Tissue-Adhesive Chondroitin Sulfate Hydrogel for Cartilage Reconstruction

Shin

Kang

Choi

et al. 2021

ACS Biomater. Sci. Eng.

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Chondroitin sulfate (CS), the main component of cartilage extracellular matrix, has attracted attention as a biomaterial for cartilage tissue engineering. However, current CS hydrogel systems still have limitations for application in successful cartilage tissue engineering owing to their unsuitable degradation kinetics, insufficient mechanical similarity, and lack of integration with the native cartilage tissue. In this study, using mussel adhesive-inspired catechol chemistry, we developed a functional CS hydrogel that exhibits tunable physical and mechanical properties as well as excellent tissue adhesion for efficient integration with native tissues. Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. CS-CA hydrogels exhibited significantly increased modulus (∼10 kPa) and superior adhesive properties (∼3 N) over conventional CS hydrogels (∼hundreds Pa and ∼0.05 N). In addition, CS-CA hydrogels incorporating decellularized cartilage tissue dice promoted the chondrogenic differentiation of human adipose-derived mesenchymal stem cells by providing a cartilage-like microenvironment. Finally, the transplantation of autologous cartilage dice using tissue-adhesive CS-CA hydrogels enhanced cartilage integration with host tissue and neo-cartilage formation owing to favorable physical, mechanical, and biological properties for cartilage formation. In conclusion, our study demonstrated the potential utility of the CS-CA hydrogel system in cartilage tissue reconstruction.

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“…Aside from its biocompatibility, nonallergenicity and biodegradability as key characteristics 28 , chitosan possess antibacterial, anti-tumour, anti-fungal, immune-adjuvant, anti-thrombogenic, anti-cholesterol, and bio-adhesive activities 29 . Chitosan in the form of fibrous porous scaffolds is used in tissue regeneration of bone 30 , cartilage 31 , intervertebral disc 32 , blood vessel 33 , cornea 34 as well as wound regeneration 35 . Chitosan and its corresponding ionic complexes and their blends with synthetic or natural polymers are used in drug encapsulation, cell immobilization, and as a carrier in gene transfection 36 .…”

Section: Properties and Processing Of Chitosanmentioning

confidence: 99%

A Review On Electropsun Chitosan Fibers For Bone Tissue Defects

Siddiqui¹,

Karthik²,

Adapala³

et al. 2022

Int J Life Sci Pharm Res

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Bone tissue engineering has been an evolving field for decades in view of its intrinsic potential to regenerate and the necessity of repair in response to injuries or disorders. Scaffold implantation is one of the most applied techniques to overcome the donor crisis leading to bone regeneration using osteoinducible cells. Numerous combinations of scaffold composites are being designed in-order to achieve the maximum regeneration considering the parameters such as bio-compatibility, biodegradability osteo conductivity, mechanical strength and hydrophilicity that helps in the assessment of the possible negative impacts of the healing process. This review article concentrates on some of such composites where the chitosan, a natural polymer, is combined with the other biopolymers like synthetic and ceramic polymers at various concentrations and treatments reporting the desired results. The distinct characteristic of this review is that it focuses on the scaffolds that are completely Nano fibrous in nature fabricated by electro spinning. In this review, we reported the results of various combinations of chitosan and their significance. The ability to form (Calcium and Phosphate crystals-Biomineralization) is evident that chitosan combined with the other biopolymers can be contemplated as phenomenal scaffold as the used seed cells are clinically applied across the world – human mesenchymal stem cells (hMSCs), bone marrow mesenchymal stem cells (BM-MSCs), mouse mesenchymal stem cells (mMSCs), human fetal osteoblasts (hFOB), etc. Apart from the in-vitro studies, the results of in-vivo experiments were also included in this article where the implantation targets the calvarial bone regeneration. Besides osteogenic differentiation, this article highlighted the prominent efficiency of the scaffolds to exhibit the antimicrobial activity and to act as drug delivery system when doped with components like AgNO3, Chlorhexidine, ZnO and Amoxicillin, Sinapic acid respectively. Overall, in the current review, we tried to focus on consolidation of various results related to chitosan based nanofibers for bone tissue remodeling.

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Strategies towards Orthopaedic Tissue Engineered Graft Generation: Current Scenario and Application

Cited by 15 publications

References 128 publications

Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

Tissue-Adhesive Chondroitin Sulfate Hydrogel for Cartilage Reconstruction

A Review On Electropsun Chitosan Fibers For Bone Tissue Defects

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