Strategy and design in fluorous phase immobilization:�a systematic study of the effect of ?pony tails? (CH2)3(CF2)n?1CF3 on the partition coefficients of �benzenoid compounds

Abstract

Background Personal construct Theory (PCP) may provide a way for people who are violent and have schizophrenia to understand and modify their behaviour. The ability to reconstrue personal relationships may lead to greater acceptance of perceived or real stresses and increased tolerance. Method A year‐long pilot study tested the feasibility of PCP‐oriented psychotherapy amongst long‐term male residents with schizophrenia in Broadmoor Hospital, all of whom had committed violent acts. A matched group completed the same instruments, but did not receive group psychotherapy. Six of the eight subjects from the index group completed the therapy, but instrument compliance varied. Results for group data cannot be presented, but an individual case report is offered, demonstrating the changes in construing that occurred over the year. These included elaboration accompanied by changes in mood, and the formation of a more appropriate construct system for managing personal relationships. Conclusions The model for therapy is feasible within a secure environment, although there are ethical issues. The evaluation of outcome requires substantial modification, and the issue of subject cooperation needs further attention. The pilot does, however, suggest that such work is then worth more substantial study, including randomization between treatment and non‐treatment groups. Copyright © 1998 Whurr Publishers Ltd.

Alternative statistical and theoretical analysis of fluorophilicity

“…This value is currently transformed onto a free energy scale by taking its natural logarithm, and the resulting quantity ln P is referred to as the ''fluorophilicity''. Throughout this paper we will use the same standard system employed by Huque et al [16] and originally proposed by Rocaboy et al [18], that is to say, the partition of molecules between perfluoro (methylcyclohexane), CF 3 C 6 F 11 , and toluene, given by…”

Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle

“…The partition coefficients for the hydrocarbon and fluorocarbon prodrugs in a perfluoro(methylcyclohexane)-toluene system or PFOB-water were determined by FID gas chromatography (Varian CP-3800) analysis of the fluorocarbon phase (Rocaboy et al, 2000). The nicotinic acid esters were initially dissolved in 3 mL or 5.5 mL volumes of fluorinated solvent (PFOB or PFMCH) to achieve a known concentration in the range of 1 mM to 7.0 mM.…”

Fluorous modification of 2,2′-bipyridine

“…Ligand design for use in FBS protocol typically involves maximizing the number of fluorine atoms incorporated to ensure complete immobilization of the new ligand in the fluorous recovery solvent [4,5]. The electronic impact (inductive electron-withdrawing effect) of the appended fluorocarbon substituent is not always desirable.…”