Strategy for Diagnosis of Congenital Toxoplasmosis: Evaluation of Methods Comparing Mothers and Newborns and Standard Methods for Postnatal Detection of Immunoglobulin G, M, and A Antibodies

Pinon, J. M.; Dumon, H.; Chemla, Cathy; Franck, Jacqueline; Petersen, Eskild; Lebech, Morten; Zufferey, J.; Bessières, M H; Marty, Pierre; Holliman, R E; Johnson, Julie; Luyasu, Victor; Lécolier, B; Guy, Edward; Joynson, D. H. M.; Decoster, A.; Enders, Gisela; Pelloux, Hervé; Candolfi, Ermanno

doi:10.1128/jcm.39.6.2267-2271.2001

Cited by 136 publications

(75 citation statements)

References 27 publications

(24 reference statements)

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“…Infant serum collected at 1 month of age was negative for anti-WNV IgM, and serum collected at 8 months of age was negative for anti-WNV IgM and had no detectable WNV-neutralizing antibody, suggesting that the IgM detected in cord blood of this infant was of maternal origin (an unusual occurrence) or that the test was falsely positive. 34 At 6 months of age, the infant seemed healthy and had normal growth and development. WNV RT-PCR was performed on 46 cord blood specimens and 50 cord tissue specimens tested; all were negative.…”

Section: Laboratory Testing For Wnv Infectionmentioning

confidence: 99%

Birth Outcomes Following West Nile Virus Infection of Pregnant Women in the United States: 2003-2004

et al. 2006

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Section: Laboratory Testing For Wnv Infectionmentioning

confidence: 99%

Birth Outcomes Following West Nile Virus Infection of Pregnant Women in the United States: 2003-2004

et al. 2006

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“…When toxoplasmosis infection is suspected in a woman during pregnancy or before pregnancy, the diagnosis is primarily made by serological investigation (Pinon et al, 2001). Detection of Toxoplasma specific antibodies is the primary diagnostic method in determining the parasite infection.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

“…Presence of IgG antibodies only signify exposure because asymptomatic humans can develop very high T.gondii antibody titers and titer may remain high for many years or even whole year if repeated exposures are encountered. Recent infection can be identified by an 8-fold rise in antibodies titer; taken two weeks apart (Pinon et al, 2001). …”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Congenital Toxoplasmosis: A Review of its Pathology, Immune Response and Current Treatment Options.

Wellington¹,

Oladipo²,

Chimere

et al. 2010

Sierra Leone j. biomed. res.

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Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is one of the most common parasites of man and other warm-blooded animals. Humans are infected through contaminated food, water, and blood transfusion, organ transplantation or from mother to foetus through the placenta. Severe congenital infections occur as a result of primary T. gondii infection in early pregnancy. Transmission of T.gondii to the foetus can result in serious health problems, including mental retardation, seizures, blindness and death. Frequency of foetal infection is higher when maternal infection occurs later in pregnancy and sequelae are more severe when maternal infections occur early in the first trimester of pregnancy. The ability of the parasite to survive intracellularly largely depends on the blocking of different proapoptotic signaling cascades of the host cells. During pregnancy, however, alterations in the incidence of apoptosis are associated with abnormal placental morphology and function. Both cellular and humoral immune responses control T.gondii infection. Toxoplasma is asymptomatic, infected women can only be detected by serological testing. In many instances, congenital toxoplasmosis can be prevented by educating pregnant women and women of childbearing age about the route of transmission. The need for screening suspected cases of T. gondii will help reduce transmission to the foetus.

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“…IgA dosage is an important acute phase marker, and has shown good sensitivity in several studies associated with IgM dosage for Toxoplasma gondii, both in pregnancy and for the diagnosis of newborns 23,24 .…”

Section: Conflict Of Interest Referencesmentioning

confidence: 99%

Profile of pregnant women and children treated at a reference center for congenital toxoplasmosis in the northern state of Minas Gerais, Brazil

Soares

Carvalho

Caldeira

2012

Rev. Soc. Bras. Med. Trop.

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Introduction:To describe the clinical and epidemiological profile of pregnant women and children treated at a reference outpatient clinic for congenital toxoplasmosis. Methods: Pregnant women potentially exposed to Toxoplasma gondii were observed. Diagnoses were made using serologic tests compatible with acute toxoplasmosis. Children presenting with: Toxoplasma-specific antibodies (IgM or IgA or ascending IgG titers higher than maternal titers in the first 3 months of life) coupled with toxoplasmosis symptoms; intracranial calcifications (by transfontanelar ultrasound or cephalic segment tomography); or retinochoroiditis (by fundoscopy examination) in the first 8 months of life were also included in the study. Results: Fifty-eight mother-child pairs were observed (mean age of the mothers was 22.1 years). Most patients lived in urban areas (86.2%) and had attended less than 8 years of school (51.7%). Diagnosis was made after birth in 19 (32.8%) children. Thirty-four (58.6%) women received some type of treatment during pregnancy. Most (72.4%) of the children did not present with clinical alterations at birth. The main findings were ophthalmological: 20 (34.5%) children with retinochoroiditis, 17 (29.3%) with strabismus, and 7 (12.1%) with nystagmus. Of the children with retinochoroiditis, 9 presented with subnormal vision. Ten (32.3%) out of 31 children presented with intracranial calcifications by cephalic segment congenital toxoplasmosis, and 9 (42.9%) children presented with delayed psychomotor development. Conclusions: Our results highlight a critical situation. Protocols for follow-up of pregnant women and their children must be created to improve medical care and minimize sequelae.

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Strategy for Diagnosis of Congenital Toxoplasmosis: Evaluation of Methods Comparing Mothers and Newborns and Standard Methods for Postnatal Detection of Immunoglobulin G, M, and A Antibodies

Cited by 136 publications

References 27 publications

Birth Outcomes Following West Nile Virus Infection of Pregnant Women in the United States: 2003-2004

Birth Outcomes Following West Nile Virus Infection of Pregnant Women in the United States: 2003-2004

Congenital Toxoplasmosis: A Review of its Pathology, Immune Response and Current Treatment Options.

Profile of pregnant women and children treated at a reference center for congenital toxoplasmosis in the northern state of Minas Gerais, Brazil

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