Stratification of Breast Cancer Risk in Terms of the Influence of Age and Mammographic density

Abstract

<jats:p> Purpose Analysis of the influence of the singular risk factors age and breast density on the 2-year incidence of breast cancer among participants in the German mammography screening program.</jats:p><jats:p> Materials and Methods The multicenter study includes 111 456 subsequent round digital mammographic screening examinations from four screening units with prospective visual categorization of breast density. Based on detection in screening and during the 2-year interval after negative screening participation (interval cancers), 2-year breast cancer incidences (2 YBCI) (‰) were calculated in the 5-year age groups (5 YAG) of the target group 50–69 years and in the BI-RADS density categories ACR 1–4. Multivariate statistical evaluations were carried out using logistic regression models.</jats:p><jats:p> Results With an increase in the 5 YAG, the 2 YBCI increased by 5.0 ‰, 6.7 ‰, 8.5 ‰ to 9.7 ‰, and was significantly different among 55–59, 60–64 and 65–69-year-old women compared to the youngest reference group 50–54 years (odds ratio (OR): 1.34; 1.68; and 1.93; p-value &lt; 0.0001). With an increase in density categories 1–4, the 2 YBCI increased from 2.6 ‰, to 5.8 ‰, 9.6 ‰, and 9.7 ‰. The 2 YBCI differed significantly in breast density categories 2, 3, 4 from reference group 1 (OR: 2.17; 3.65; and 3.76; p-value &lt; 0.0001). Only within the two main breast density groups 2 (frequency 44.3 %) and 3 (44.7 %), a significant increase in the 2 YBCI was observed across the 5 YAG (category 2: 3.7–8.9 ‰; category 3: 5.8–11.7 ‰; p-value &lt; 0.001 each). The 2 YBCI was above the median of 7.5 ‰ in women with breast density category 2 and aged 65–69 years, as well as in women with breast density categories 3 and 4 aged 55–69 years. A 2 YBCI below the median was seen in women between 50–54 years regardless of breast density, as well as women in category 1 in all age groups.</jats:p><jats:p> Conclusion Within the main breast density categories 2 and 3 (almost 90 % of participants), incidences increase with age to double. A consistently low incidence is found regardless of breast density at a young screening age and in women with the lowest breast density.</jats:p><jats:p> Key Points: </jats:p><jats:p> Citation Format </jats:p>

Systematische und qualitätsgesicherte Früherkennung des sporadischen Mammakarzinoms

“…(4) There should be scientific studies relating to an extension of screening strategies for the small number of women in the entitlement range who have extremly dense breasts. [20]. Mit steigender 5-Jahres-Altersgruppe stieg die 2-Jahres-Brustkrebsinzidenz von 5,0 ‰, 6,7 ‰, 8,5 ‰ auf 9,7 ‰ und unterschied sich unter den 55-bis 59-, 60bis 64-und 65-bis 69-jährigen Frauen signifikant von der jüngsten Referenzgruppe 50-54 Jahre (Odds-Ratio [OR]: 1,34, 1,68 bzw.…”

BI-RADS sınıflaması meme kanseri risk faktörlerini ne oranda karşılar ve hematolojik parametrelerle ilişkisi nedir?

“…Ancak ters orantılı olarak meme kanseri gelişme riski artmaktadır. Mamografik meme yoğunluğu yüksek olan kadınlarda meme kanser riski yaş ile birlikte 2 kata kadar artmaktadır (22). Bizim çalışmamızda ise mamografik meme yoğunluğu yüksek olan kadınlarda meme kanseri riskinin 5 kat daha fazla olduğu saptandı.…”

BREAst screening Tailored for HEr (BREATHE)—A study protocol on personalised risk-based breast cancer screening programme

“…Despite a growing body of evidence illustrating the utility of PRS in population screening programmes, policy implementation has been low [ 3 ]. While the Gail model [ 27 ], mammographic density [ 39 ] and breast cancer predisposition genes [ 40 ] have been incorporated into prior risk stratification studies, implementation of PRS is less common [ 3 ].…”