Stratified Interpolyelectrolyte Complexes: Fabrication, Structure and Properties

Guzmán, Eduardo; Ruano, Marta; Ortega, Francisco; Rubio, Ramón G.

doi:10.1007/978-3-319-01680-1_9

Cited by 6 publications

(7 citation statements)

References 228 publications

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“…Thus, the lower density of the emulsion droplets in relation to the aqueous continuous phase facilitates their recovery by flotation in the layering solutions [65,66], and the use of centrifugation can be exploited to obtain an enhanced creaming yield [67][68][69]. Conversely, the separation of the excess unbound material when vesicles or liposomes are used as templates for the LbL assembly becomes even more complex, involving in some cases up to three different steps for each pair of deposited bilayers [70,71]: (i) The first layering solution is added to a diluted suspension containing vesicles/liposomes to form the first layer; (ii) the second layering solution is added to the dispersion containing the polyelectrolyte-decorated vesicles/liposomes, and the excess unbound material resulting after the deposition of the first layer, leading to the formation of the second layer and interpolyelectrolyte complexes; and (iii) the interpolyelectrolyte complexes are settled by centrifugation, and a dispersion containing the polyelectrolyte-decorated vesicles/liposomes is obtained. It should be noted that after the deposition of the first bilayer, the deposition of the subsequent bilayers can be obtained following a similar sequence.…”

Section: Towards the Fabrication Of Hollow Capsules: Immersive Assembly On Colloidal Templatesmentioning

confidence: 99%

“…However, this procedure limits the maximum number of bilayers that can be deposited to five or six because, during the separation step, the formed interpolyelectrolyte complexes can interact with the obtained capsules, leading to a loss in capsules during the centrifugation. The loss in capsules has been estimated to be around 5% of the total per deposited bilayer [70].…”

Section: Towards the Fabrication Of Hollow Capsules: Immersive Assembly On Colloidal Templatesmentioning

confidence: 99%

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Polyelectrolyte Multilayered Capsules as Biomedical Tools

et al. 2022

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Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, the exploitation of PEMUCs in the biomedical field requires a deep understanding of the most fundamental bases underlying their assembly processes, and the control of their properties to fabricate novel materials with optimized ability for specific targeting and therapeutic capacity. This review presents an updated perspective on the multiple avenues opened for the application of PEMUCs to the biomedical field, aiming to highlight some of the most important advantages offered by the LbL method for the fabrication of platforms for their use in the detection and treatment of different diseases.

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Section: Towards the Fabrication Of Hollow Capsules: Immersive Assembly On Colloidal Templatesmentioning

confidence: 99%

Section: Towards the Fabrication Of Hollow Capsules: Immersive Assembly On Colloidal Templatesmentioning

confidence: 99%

Polyelectrolyte Multilayered Capsules as Biomedical Tools

et al. 2022

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“…It is worth mentioning that the centrifugation can be useful to force a faster creaming process when emulsion droplets are used as the template [ 206 , 207 , 208 ]. The use of vesicles or liposomes as a template for LbL assembly requires a very complex process involving up to three different steps for each deposited bilayer [ 209 ]. First, the solution containing the first layer is added to a diluted suspension containing vesicles/liposomes.…”

Section: Fabrication Of Lbl Assemblies On Colloidal Surfacesmentioning

confidence: 99%

“…Once the first bilayer is deposited, the process can continue by repeating the above commented procedure up to depositing the desired number of layers. However, it should be noted that this procedure does not allow depositing more than five to six bilayers, because the formation of inter-polyelectrolyte aggregates that can form supramolecular aggregated with the polyelectrolyte-decorated vesicles/liposomes and the centrifugation process result in a 5% reduction of the total number of vesicles/liposomes per each deposited bilayer [ 209 ].…”

Section: Fabrication Of Lbl Assemblies On Colloidal Surfacesmentioning

confidence: 99%

Polyelectrolyte Multilayers on Soft Colloidal Nanosurfaces: A New Life for the Layer-By-Layer Method

et al. 2021

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The Layer-by-Layer (LbL) method is a well-established method for the assembly of nanomaterials with controlled structure and functionality through the alternate deposition onto a template of two mutual interacting molecules, e.g., polyelectrolytes bearing opposite charge. The current development of this methodology has allowed the fabrication of a broad range of systems by assembling different types of molecules onto substrates with different chemical nature, size, or shape, resulting in numerous applications for LbL systems. In particular, the use of soft colloidal nanosurfaces, including nanogels, vesicles, liposomes, micelles, and emulsion droplets as a template for the assembly of LbL materials has undergone a significant growth in recent years due to their potential impact on the design of platforms for the encapsulation and controlled release of active molecules. This review proposes an analysis of some of the current trends on the fabrication of LbL materials using soft colloidal nanosurfaces, including liposomes, emulsion droplets, or even cells, as templates. Furthermore, some fundamental aspects related to deposition methodologies commonly used for fabricating LbL materials on colloidal templates together with the most fundamental physicochemical aspects involved in the assembly of LbL materials will also be discussed.

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“…Polyelectrolyte complexation and coacervation products have been paid much attention in the last few decades − due to their properties as they are readily produced, environmentally friendly, and their synthesis corresponds to several principles of “green chemistry” (i.e., they do not require organic solvents). − These complexes can serve as a drug delivery system for enzymes and DNA because such molecules can readily be incorporated into polyelectrolyte (PE) complexes . These PE complexes can be also applied for membrane production, biosensor construction, , enzyme immobilization, and microcapsules preparation. − There are three classes of materials: coacervates, soluble complexes, and nonequilibrium complexes .…”

Section: Introductionmentioning

confidence: 99%

Humidity-Driven Transparent Holographic Free-Standing Polyelectrolyte Films

Nikolaev

Ulasevich

Luneva

et al. 2020

ACS Appl. Polym. Mater.

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In the present work, transparent holographic poly(diallyldimethylammonium chloride) (PDADMAC)/heparin and PDADMAC/poly(styrenesulfonate) (PSS) films were synthesized via polyelectrolyte coacervates. PDADMAC/heparin films were obtained without temperature treatment. Thin holographic free-standing films with a 1 μm grating period and uniform surface of a polyelectrolyte complex were readily and quickly made by pressing polyelectrolyte coacervate, the hydrated viscoelastic fluid-like form of polyelectrolyte complex precursor, between a flat surface and holographic mask. Heparin replaces PSS in film composition to prepare the sheer film. Thus, the PDADMAC/heparin holographic film demonstrates transparency and reversible response for humidity under diffraction detection. In addition to diffraction humidity signal measurements, the cobalt(II) chloride was impregnated in polyelectrolyte coacervate to make an additional colorimetric signal response. In this case, the free-standing film serves both as the substrate for the hygroscopic salt and as a diffraction humidity sensor. The PDADMAC/heparin/Co(II) chloride film demonstrates a linear humidity range from 50 to 90%. Additionally, due to hydrated inorganic salt ion size, cobalt chloride prevents film porosity, which initiates under film swelling. Based on the results and calculations obtained, the study proposes the mechanism of water incorporation, including the reptation model and polyelectrolyte complex behavior. Results of density functional theory calculations prove that binding of cobalt aqua complexes [Co(H2O)6]2+ with the dimeric associates heparin/PDADMAC via noncovalent interactions (hydrogen bonds) additionally is much more energetically favorable compared with the alternative association of heparin/PDADMAC with water molecules.

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Stratified Interpolyelectrolyte Complexes: Fabrication, Structure and Properties

Cited by 6 publications

References 228 publications

Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polyelectrolyte Multilayers on Soft Colloidal Nanosurfaces: A New Life for the Layer-By-Layer Method

Humidity-Driven Transparent Holographic Free-Standing Polyelectrolyte Films

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