Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings

Penile warty mucoepidermoid carcinoma with features of stratified mucin‐producing intra‐epithelial lesion and invasive stratified mucin‐producing carcinoma

“…The mucinous components, in‐situ and invasive, of our case were morphologically indistinguishable from the recently reported SMILE/ISMC of the uterine cervix and penile SMILE . Our case accompanied various in‐situ and invasive penile tumours, as was seen in reported cases of SMILE .…”

“…We report herein an undescribed mixed penile carcinoma consisting of an intra‐epithelial and invasive mucin‐producing tumour, which was similar histologically to previously published cases of penile MEC/SMILE and SMILE/ISMC of the uterine cervix . To confirm the tumour subtype in our case, we evaluated the chromosomal translocations of MAML2 and EWSR1 genes with fluorescence in‐situ hybridisation (FISH), p16 immunoreactivity and HPV genotyping.…”

“…In addition, SMILE is associated with various types of non-invasive and invasive cervical tumours, such as high-grade stratified intra-epithelial lesions, in-situ and invasive adenocarcinoma, ASC and SCC. [21][22][23][24] We report herein an undescribed mixed penile carcinoma consisting of an intra-epithelial and invasive mucin-producing tumour, which was similar histologically to previously published cases of penile MEC/SMILE [5][6][7]20 and SMILE/ISMC of the uterine cervix. [21][22][23][24] To confirm the tumour subtype in our case, we evaluated the chromosomal translocations of MAML2 and EWSR1 genes with fluorescence in-situ hybridisation (FISH), p16 immunoreactivity and HPV genotyping.…”

“…proposed a new type of mucin‐producing penile tumour, the penile analogue of stratified mucin‐producing intra‐epithelial lesions (SMILEs) of the uterine cervix. SMILE and invasive stratified mucin‐producing carcinoma (ISMC), with morphological features identical to SMILE, have been reported as uterine cervix mucin‐producing tumours . SMILE is postulated to be induced by high‐risk human papillomavirus (HPV) and is characterised histologically by a stratified epithelium with atypical cells containing varying quantities of intracytoplasmic mucin throughout the majority of the epithelium.…”

“…SMILE and invasive stratified mucin-producing carcinoma (ISMC), with morphological features identical to SMILE, have been reported as uterine cervix mucin-producing tumours. [21][22][23][24] SMILE is postulated to be induced by high-risk human papillomavirus (HPV) and is characterised histologically by a stratified epithelium with atypical cells containing varying quantities of intracytoplasmic mucin throughout the majority of the epithelium. In addition, SMILE is associated with various types of non-invasive and invasive cervical tumours, such as high-grade stratified intra-epithelial lesions, in-situ and invasive adenocarcinoma, ASC and SCC.…”